Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms

Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms

Summary: Various culture methods have been developed for maintaining human pluripotent stem cells (PSCs). These PSC maintenance methods exhibit biased differentiation; for example, feeder-dependent PSCs efficiently yield cerebral organoids, but it is difficult to generate organoids from feeder-free...

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Bibliographic Details
Main Authors: Hirosato Ideno, Kent Imaizumi, Hiroko Shimada, Tsukasa Sanosaka, Akisa Nemoto, Jun Kohyama, Hideyuki Okano
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Cell biology
Stem cells research
Omics
Genomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222014122

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