Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination

Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination

Neuropathic pain (NP) affects 7%–10% of the general population and is still hard to cure. Here, we validated the therapeutic effect and demonstrated the mechanism of paeoniflorin and liquiritin combination (PL) on NP from the perspective of integrated lipidomics and transcriptomics for the first tim...

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Bibliographic Details
Main Authors: Yan-Yan Chen, Li-Mei Feng, Ding-Qiao Xu, Shi-Jun Yue, Rui-Jia Fu, Mei-Mei Zhang, Yu-Ping Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
paeoniflorin
liquiritin
neuropathic pain
lipid metabolism
calcium signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.944386/full

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