Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels

Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels

In the striatum, acetylcholine (ACh) neuron activity is modulated co-incident with dopamine (DA) release in response to unpredicted rewards and reward-predicting cues and both neuromodulators are thought to regulate each other. While this co-regulation has been studied using stimulation studies, the...

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Bibliographic Details
Main Authors: Kelly M Martyniuk, Arturo Torres-Herraez, Daniel C Lowes, Marcelo Rubinstein, Marie A Labouesse, Christoph Kellendonk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
neuromodulation
circuit
motivation
dopamine
acetylcholine
striatum
Online Access:https://elifesciences.org/articles/76111

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