Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis
Abstract Background An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive i...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2405 |
| _version_ | 1827877410488451072 |
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| author | Clàudia Coll‐Martinez Ester Quintana Judit Salavedra‐Pont Maria Buxó Marina González‐del‐Rio Immaculada Gómez María Muñoz‐San Martín Luisa María Villar Gary Álvarez‐Bravo René Robles‐Cedeño Lluís Ramió‐Torrentà Jordi Gich |
| author_facet | Clàudia Coll‐Martinez Ester Quintana Judit Salavedra‐Pont Maria Buxó Marina González‐del‐Rio Immaculada Gómez María Muñoz‐San Martín Luisa María Villar Gary Álvarez‐Bravo René Robles‐Cedeño Lluís Ramió‐Torrentà Jordi Gich |
| author_sort | Clàudia Coll‐Martinez |
| collection | DOAJ |
| description | Abstract Background An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods Forty‐four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow‐up was compared adjusting by age, education, anxiety–depression, and baseline performance. Results LS‐OCMB+ patients only performed worse for Long‐Term Storage in the Selective Reminding Test (p = .018). Conclusion There are no remarkable cognitive differences between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS. |
| first_indexed | 2024-03-12T17:37:03Z |
| format | Article |
| id | doaj.art-c1dc6fb9cc504fe096a25e7b0c381dfa |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:37:03Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-c1dc6fb9cc504fe096a25e7b0c381dfa2023-08-04T10:55:54ZengWileyBrain and Behavior2162-32792021-12-011112n/an/a10.1002/brb3.2405Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosisClàudia Coll‐Martinez0Ester Quintana1Judit Salavedra‐Pont2Maria Buxó3Marina González‐del‐Rio4Immaculada Gómez5María Muñoz‐San Martín6Luisa María Villar7Gary Álvarez‐Bravo8René Robles‐Cedeño9Lluís Ramió‐Torrentà10Jordi Gich11Girona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital Girona/Salt SpainNeurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta Salt SpainGirona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital Girona/Salt SpainInstitut d'Investigació Biomèdica de Girona Dr. Josep Trueta Salt SpainGirona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital Girona/Salt SpainNeurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta Salt SpainNeurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta Salt SpainREEM, Multiple Sclerosis Spanish Network Instituo de Salud Carlos III Madrid SpainGirona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital Girona/Salt SpainGirona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital Girona/Salt SpainGirona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital Girona/Salt SpainGirona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital Girona/Salt SpainAbstract Background An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods Forty‐four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow‐up was compared adjusting by age, education, anxiety–depression, and baseline performance. Results LS‐OCMB+ patients only performed worse for Long‐Term Storage in the Selective Reminding Test (p = .018). Conclusion There are no remarkable cognitive differences between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS.https://doi.org/10.1002/brb3.2405biomarkerscognitive impairmentmultiple sclerosisneuropsychologyoligoclonal bands |
| spellingShingle | Clàudia Coll‐Martinez Ester Quintana Judit Salavedra‐Pont Maria Buxó Marina González‐del‐Rio Immaculada Gómez María Muñoz‐San Martín Luisa María Villar Gary Álvarez‐Bravo René Robles‐Cedeño Lluís Ramió‐Torrentà Jordi Gich Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis Brain and Behavior biomarkers cognitive impairment multiple sclerosis neuropsychology oligoclonal bands |
| title | Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis |
| title_full | Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis |
| title_fullStr | Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis |
| title_full_unstemmed | Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis |
| title_short | Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis |
| title_sort | assessing the presence of oligoclonal igm bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis |
| topic | biomarkers cognitive impairment multiple sclerosis neuropsychology oligoclonal bands |
| url | https://doi.org/10.1002/brb3.2405 |
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