Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil
Abstract Introduction Molecular studies about carcinomas of the oral cavity and oropharynx demonstrate the presence of human papilomavirus genome in these tumors, reinforcing the participation of human papilomavirus in oral carcinogenesis. Objectives This study aimed to determine the prevalence of...
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Elsevier
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| Series: | Brazilian Journal of Otorhinolaryngology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000100038&lng=en&tlng=en |
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| author | Guilherme Petito Megmar Aparecida dos Santos Carneiro Sílvia Helena de Rabello Santos Antonio Marcio Teodoro Cordeiro Silva Rita de Cassia Alencar Antonio Paulo Gontijo Vera Aparecida Saddi |
| author_facet | Guilherme Petito Megmar Aparecida dos Santos Carneiro Sílvia Helena de Rabello Santos Antonio Marcio Teodoro Cordeiro Silva Rita de Cassia Alencar Antonio Paulo Gontijo Vera Aparecida Saddi |
| author_sort | Guilherme Petito |
| collection | DOAJ |
| description | Abstract Introduction Molecular studies about carcinomas of the oral cavity and oropharynx demonstrate the presence of human papilomavirus genome in these tumors, reinforcing the participation of human papilomavirus in oral carcinogenesis. Objectives This study aimed to determine the prevalence of human papilomavirus and genotype distribution of HPV16 and HPV18 in oral cavity and oropharynx carcinomas, as well as their association with clinical characteristics of the tumors. Methods This is a retrospective study, with clinical data collected from 82 patients. Human papilomavirus detection was conducted on specimens of oral cavity and oropharynx carcinomas included in paraffin blocks. Patients were assisted in a cancer reference center, in the central region of Brazil, between 2005 and 2007. Polymerase chain reaction was used for the detection and genotyping of human papilomavirus. Results Among the patients evaluated, 78% were male. The average age of the group was about 58 years. Risk factors, such as smoking (78%) and alcohol consumption (70.8%) were recorded for the group. HPV DNA was detected in 21 cases (25.6%; 95% confidence interval 16.9–36.6) of which 33.3% were HPV16 and 14.3% were HPV18. The presence of lymph node metastases and registered deaths were less frequent in human papilomavirus positive tumors, suggesting a better prognosis for these cases; however, the differences between the groups were not statistically significant. Conclusion The results obtained in the present study, with respect to the presence of the high-risk HPV16 and HPV18 genotypes, highlight the importance of human papilomavirus vaccination in the control of oral cavity and oropharynx carcinomas. |
| first_indexed | 2024-12-17T23:45:48Z |
| format | Article |
| id | doaj.art-c1dca9e0f14f40e990281f4f98e5d14d |
| institution | Directory Open Access Journal |
| issn | 1808-8686 |
| language | English |
| last_indexed | 2024-12-17T23:45:48Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-c1dca9e0f14f40e990281f4f98e5d14d2022-12-21T21:28:20ZengElsevierBrazilian Journal of Otorhinolaryngology1808-8686831384410.1016/j.bjorl.2016.01.004S1808-86942017000100038Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of BrazilGuilherme PetitoMegmar Aparecida dos Santos CarneiroSílvia Helena de Rabello SantosAntonio Marcio Teodoro Cordeiro SilvaRita de Cassia AlencarAntonio Paulo GontijoVera Aparecida SaddiAbstract Introduction Molecular studies about carcinomas of the oral cavity and oropharynx demonstrate the presence of human papilomavirus genome in these tumors, reinforcing the participation of human papilomavirus in oral carcinogenesis. Objectives This study aimed to determine the prevalence of human papilomavirus and genotype distribution of HPV16 and HPV18 in oral cavity and oropharynx carcinomas, as well as their association with clinical characteristics of the tumors. Methods This is a retrospective study, with clinical data collected from 82 patients. Human papilomavirus detection was conducted on specimens of oral cavity and oropharynx carcinomas included in paraffin blocks. Patients were assisted in a cancer reference center, in the central region of Brazil, between 2005 and 2007. Polymerase chain reaction was used for the detection and genotyping of human papilomavirus. Results Among the patients evaluated, 78% were male. The average age of the group was about 58 years. Risk factors, such as smoking (78%) and alcohol consumption (70.8%) were recorded for the group. HPV DNA was detected in 21 cases (25.6%; 95% confidence interval 16.9–36.6) of which 33.3% were HPV16 and 14.3% were HPV18. The presence of lymph node metastases and registered deaths were less frequent in human papilomavirus positive tumors, suggesting a better prognosis for these cases; however, the differences between the groups were not statistically significant. Conclusion The results obtained in the present study, with respect to the presence of the high-risk HPV16 and HPV18 genotypes, highlight the importance of human papilomavirus vaccination in the control of oral cavity and oropharynx carcinomas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000100038&lng=en&tlng=enPapillomaviridaePapillomaviridae 16Neoplasia de cabeça e pescoçoEpidemiologia |
| spellingShingle | Guilherme Petito Megmar Aparecida dos Santos Carneiro Sílvia Helena de Rabello Santos Antonio Marcio Teodoro Cordeiro Silva Rita de Cassia Alencar Antonio Paulo Gontijo Vera Aparecida Saddi Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil Brazilian Journal of Otorhinolaryngology Papillomaviridae Papillomaviridae 16 Neoplasia de cabeça e pescoço Epidemiologia |
| title | Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil |
| title_full | Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil |
| title_fullStr | Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil |
| title_full_unstemmed | Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil |
| title_short | Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil |
| title_sort | human papillomavirus in oral cavity and oropharynx carcinomas in the central region of brazil |
| topic | Papillomaviridae Papillomaviridae 16 Neoplasia de cabeça e pescoço Epidemiologia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000100038&lng=en&tlng=en |
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