Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects
Background: Immunosuppressive Acidic protein (IAP) is a marker of the extent of immune defects occurring in most cancers. Its correlation with CD4 cell count used as an indicator of immune function and disease progression in Human Immuno-deficiency Virus (HIV) infection is not well documented. Ai...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2017-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/17323 |
| _version_ | 1818256350307680256 |
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| author | Olayanju Ayodeji Olusola |
| author_facet | Olayanju Ayodeji Olusola |
| author_sort | Olayanju Ayodeji Olusola |
| collection | DOAJ |
| description | Background: Immunosuppressive Acidic protein (IAP) is a marker of the extent of immune defects occurring in most cancers. Its correlation with CD4 cell count used as an indicator of immune function and disease progression in Human Immuno-deficiency Virus (HIV) infection is not well documented.
Aims and Objectives: To determine if IAP levels correlates with immunosupression and haematopathology occurring in HIV/AIDS infection.
Materials and Methods: This cross sectional study was conducted at the Federal Teaching Hospital, Ido-Ekiti. One hundred and five participants consisting of 85 HIV infected test subjects and 20 control subjects were enrolled into the study. CD4 counts was obtained using SL Cyflow machine, IAP levels determined using ELISA kit for human IAP and Full blood count for all participants was obtained using Sysmex KX-21N Haematology Analyzer. Regression and correlation analysis was done on data using SPSS 28.
Results: IAP showed a negative correlation with CD4 count (r= -0.6), (r= -0.9) and (r= -0.2) in the ART, NART and control groups. The pattern of the results was similar with other parameters except in Neutrophils (r= 0.2) (r= 0.3) and (0.1), Eosinophil (r= 0.6) (r= -0.4) and (r= -0.2) and Lymphocyte (r = -0.3) (r= -0.02) and (r= 0.05) in the ART, NART and control groups respectively. C
Conclusion: The outcome of this study show that a strong negative relationship exist between IAP and other immunohaematological parameters used for monitoring Immune status in HIV infection; however the information gotten is not sufficient to indicate IAP as a predictor of immune status in HIV infection. Further studies are therefore required to better elucidate the mechanism of increased IAP levels at different clinical stages of HIV infection. |
| first_indexed | 2024-12-12T17:26:21Z |
| format | Article |
| id | doaj.art-c1dcbb608f5a4b54a8a5e04e91ddd3dc |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-12T17:26:21Z |
| publishDate | 2017-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-c1dcbb608f5a4b54a8a5e04e91ddd3dc2022-12-22T00:17:32ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762017-08-0185816https://doi.org/10.3126/ajms.v8i5.17323Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjectsOlayanju Ayodeji Olusola 0Senior Lecturer, Department of Medical Laboratory Science, College of Medicine and Health Sciences, AfeBabalola University, PMB 5454, Ado-Ekiti, Ekiti State, Nigeria http://orcid.org/0000-0001-9365-5564Background: Immunosuppressive Acidic protein (IAP) is a marker of the extent of immune defects occurring in most cancers. Its correlation with CD4 cell count used as an indicator of immune function and disease progression in Human Immuno-deficiency Virus (HIV) infection is not well documented. Aims and Objectives: To determine if IAP levels correlates with immunosupression and haematopathology occurring in HIV/AIDS infection. Materials and Methods: This cross sectional study was conducted at the Federal Teaching Hospital, Ido-Ekiti. One hundred and five participants consisting of 85 HIV infected test subjects and 20 control subjects were enrolled into the study. CD4 counts was obtained using SL Cyflow machine, IAP levels determined using ELISA kit for human IAP and Full blood count for all participants was obtained using Sysmex KX-21N Haematology Analyzer. Regression and correlation analysis was done on data using SPSS 28. Results: IAP showed a negative correlation with CD4 count (r= -0.6), (r= -0.9) and (r= -0.2) in the ART, NART and control groups. The pattern of the results was similar with other parameters except in Neutrophils (r= 0.2) (r= 0.3) and (0.1), Eosinophil (r= 0.6) (r= -0.4) and (r= -0.2) and Lymphocyte (r = -0.3) (r= -0.02) and (r= 0.05) in the ART, NART and control groups respectively. C Conclusion: The outcome of this study show that a strong negative relationship exist between IAP and other immunohaematological parameters used for monitoring Immune status in HIV infection; however the information gotten is not sufficient to indicate IAP as a predictor of immune status in HIV infection. Further studies are therefore required to better elucidate the mechanism of increased IAP levels at different clinical stages of HIV infection.https://www.nepjol.info/index.php/AJMS/article/view/17323immunosuppressive acidic proteincd4hiv/aidsimmunosuppressionhaematopathology |
| spellingShingle | Olayanju Ayodeji Olusola Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects Asian Journal of Medical Sciences immunosuppressive acidic protein cd4 hiv/aids immunosuppression haematopathology |
| title | Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects |
| title_full | Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects |
| title_fullStr | Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects |
| title_full_unstemmed | Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects |
| title_short | Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects |
| title_sort | immunosuppressive acidic protein haematological correlates in hiv infected subjects |
| topic | immunosuppressive acidic protein cd4 hiv/aids immunosuppression haematopathology |
| url | https://www.nepjol.info/index.php/AJMS/article/view/17323 |
| work_keys_str_mv | AT olayanjuayodejiolusola immunosuppressiveacidicproteinhaematologicalcorrelatesinhivinfectedsubjects |