Fenofibrate-induced renal dysfunction, yes or no?
In the treatment process of hypertriglyceridemia and diabetic nephropathy in type 2 diabetes, fenofibrate (FEN) is a well-known medication. FEN is from fibrate class drugs that using orally; however, as a side effect, it is associated with serum creatinine level increasing. The aim of this review wa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=39;epage=39;aulast= |
| _version_ | 1818980096308936704 |
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| author | Fatemeh Emami Amirali Hariri Mohammad Matinfar Mehdi Nematbakhsh |
| author_facet | Fatemeh Emami Amirali Hariri Mohammad Matinfar Mehdi Nematbakhsh |
| author_sort | Fatemeh Emami |
| collection | DOAJ |
| description | In the treatment process of hypertriglyceridemia and diabetic nephropathy in type 2 diabetes, fenofibrate (FEN) is a well-known medication. FEN is from fibrate class drugs that using orally; however, as a side effect, it is associated with serum creatinine level increasing. The aim of this review was to determine the real effect of FEN therapy on renal functions based on both experimental and clinical studies. For this review, using the keywords of “fenofibrate” and “renal” and “function,” a variety of sources of information banks, including PubMed, Google Scholar, and Scopus, were used, and the published articles were considered and interpreted. Followed by searching in databases, 45 articles were collected. After screening these articles, based on the study source, they were devided into two parts: 23 articles on animal experiments and 22 articles clinical experiments. Based on this information, it seems that the protective mechanism of FEN is related to vascular endothelial functions. The increased creatinine by FEN is related to different sensitivities to FEN effects caused by a polymorphism in different patients. In patients with normal renal function, follow-up of serum creatinine would be necessary after FEN, but the discontinuation of FEN is not recommended. In addition, in diabetic patients with hypertriglyceridemia, FEN treatment would be suggested for protecting the kidney from diabetes-induced renal injury. |
| first_indexed | 2024-12-20T17:09:59Z |
| format | Article |
| id | doaj.art-c1dcc47284384c379b61bcbaacff1304 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-20T17:09:59Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-c1dcc47284384c379b61bcbaacff13042022-12-21T19:32:11ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362020-01-01251393910.4103/jrms.JRMS_772_19Fenofibrate-induced renal dysfunction, yes or no?Fatemeh EmamiAmirali HaririMohammad MatinfarMehdi NematbakhshIn the treatment process of hypertriglyceridemia and diabetic nephropathy in type 2 diabetes, fenofibrate (FEN) is a well-known medication. FEN is from fibrate class drugs that using orally; however, as a side effect, it is associated with serum creatinine level increasing. The aim of this review was to determine the real effect of FEN therapy on renal functions based on both experimental and clinical studies. For this review, using the keywords of “fenofibrate” and “renal” and “function,” a variety of sources of information banks, including PubMed, Google Scholar, and Scopus, were used, and the published articles were considered and interpreted. Followed by searching in databases, 45 articles were collected. After screening these articles, based on the study source, they were devided into two parts: 23 articles on animal experiments and 22 articles clinical experiments. Based on this information, it seems that the protective mechanism of FEN is related to vascular endothelial functions. The increased creatinine by FEN is related to different sensitivities to FEN effects caused by a polymorphism in different patients. In patients with normal renal function, follow-up of serum creatinine would be necessary after FEN, but the discontinuation of FEN is not recommended. In addition, in diabetic patients with hypertriglyceridemia, FEN treatment would be suggested for protecting the kidney from diabetes-induced renal injury.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=39;epage=39;aulast=creatininefenofibraterenal dysfunction |
| spellingShingle | Fatemeh Emami Amirali Hariri Mohammad Matinfar Mehdi Nematbakhsh Fenofibrate-induced renal dysfunction, yes or no? Journal of Research in Medical Sciences creatinine fenofibrate renal dysfunction |
| title | Fenofibrate-induced renal dysfunction, yes or no? |
| title_full | Fenofibrate-induced renal dysfunction, yes or no? |
| title_fullStr | Fenofibrate-induced renal dysfunction, yes or no? |
| title_full_unstemmed | Fenofibrate-induced renal dysfunction, yes or no? |
| title_short | Fenofibrate-induced renal dysfunction, yes or no? |
| title_sort | fenofibrate induced renal dysfunction yes or no |
| topic | creatinine fenofibrate renal dysfunction |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=39;epage=39;aulast= |
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