Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy
Our previous studies showed successful treatment of a series of 36 oral verrucous hyperplasia lesions and of an extensive oral verrucous carcinoma with a topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (topical ALA-PDT) protocol (with a fluence rate of 100 mW/cm2 and a light exposu...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-03-01
|
| Series: | Journal of Dental Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1991790210600062 |
| _version_ | 1818519890181488640 |
|---|---|
| author | Hsin-Ming Chen Chuan-Hang Yu Hung-Pin Lin Hsiang Yang Ru-Cheng Kuo Ying-Shiung Kuo Chun-Pin Chiang |
| author_facet | Hsin-Ming Chen Chuan-Hang Yu Hung-Pin Lin Hsiang Yang Ru-Cheng Kuo Ying-Shiung Kuo Chun-Pin Chiang |
| author_sort | Hsin-Ming Chen |
| collection | DOAJ |
| description | Our previous studies showed successful treatment of a series of 36 oral verrucous hyperplasia lesions and of an extensive oral verrucous carcinoma with a topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (topical ALA-PDT) protocol (with a fluence rate of 100 mW/cm2 and a light exposure dose of 100 J/cm2) using a 635-nm light-emitting diode (LED) light source. In this case report, we tested whether an enhanced topical ALA-PDT protocol (with a fluence rate of 200 mW/cm2 and a light exposure dose of 200 J/cm2) could be used to treat an early invasive oral squamous cell carcinoma (OSCC) with a verrucous appearance of the left lower posterior edentulous alveolar mucosa of a 67-year-old male former areca-quid chewer and ex-smoker. The main verrucous lesion showed complete regression after eight treatments with PDT. However, 10 extra treatments were needed to eradicate the multiple residual leukoplakia lesions on the edentulous alveolar mucosa. Moderate to severe post-PDT pain was noted during the initial eight treatments, and the patient needed analgesics (codeine phosphate, 30 mg three times daily) to control the pain. No recurrence of the OSCC lesion was found after a follow-up period of 4 years. We suggest that our enhanced topical ALA-PDT protocol may have good potential to be used as a treatment of choice for a superficially invasive OSCC without regional or distant metastasis before the commencement of other effective therapies. |
| first_indexed | 2024-12-11T01:30:06Z |
| format | Article |
| id | doaj.art-c1ddc58586f84b63a12e4cefb402deb9 |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-12-11T01:30:06Z |
| publishDate | 2010-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-c1ddc58586f84b63a12e4cefb402deb92022-12-22T01:25:24ZengElsevierJournal of Dental Sciences1991-79022010-03-0151364010.1016/S1991-7902(10)60006-2Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapyHsin-Ming Chen0Chuan-Hang Yu1Hung-Pin Lin2Hsiang Yang3Ru-Cheng Kuo4Ying-Shiung Kuo5Chun-Pin Chiang6Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, Far Eastern Memorial Hospital, Taipei, TaiwanGraduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanOur previous studies showed successful treatment of a series of 36 oral verrucous hyperplasia lesions and of an extensive oral verrucous carcinoma with a topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (topical ALA-PDT) protocol (with a fluence rate of 100 mW/cm2 and a light exposure dose of 100 J/cm2) using a 635-nm light-emitting diode (LED) light source. In this case report, we tested whether an enhanced topical ALA-PDT protocol (with a fluence rate of 200 mW/cm2 and a light exposure dose of 200 J/cm2) could be used to treat an early invasive oral squamous cell carcinoma (OSCC) with a verrucous appearance of the left lower posterior edentulous alveolar mucosa of a 67-year-old male former areca-quid chewer and ex-smoker. The main verrucous lesion showed complete regression after eight treatments with PDT. However, 10 extra treatments were needed to eradicate the multiple residual leukoplakia lesions on the edentulous alveolar mucosa. Moderate to severe post-PDT pain was noted during the initial eight treatments, and the patient needed analgesics (codeine phosphate, 30 mg three times daily) to control the pain. No recurrence of the OSCC lesion was found after a follow-up period of 4 years. We suggest that our enhanced topical ALA-PDT protocol may have good potential to be used as a treatment of choice for a superficially invasive OSCC without regional or distant metastasis before the commencement of other effective therapies.http://www.sciencedirect.com/science/article/pii/S19917902106000625-aminolevulinic acidearly invasive oral cancertopical photodynamic therapy |
| spellingShingle | Hsin-Ming Chen Chuan-Hang Yu Hung-Pin Lin Hsiang Yang Ru-Cheng Kuo Ying-Shiung Kuo Chun-Pin Chiang Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy Journal of Dental Sciences 5-aminolevulinic acid early invasive oral cancer topical photodynamic therapy |
| title | Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy |
| title_full | Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy |
| title_fullStr | Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy |
| title_full_unstemmed | Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy |
| title_short | Successful treatment of an early invasive oral squamous cell carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy |
| title_sort | successful treatment of an early invasive oral squamous cell carcinoma with topical 5 aminolevulinic acid mediated photodynamic therapy |
| topic | 5-aminolevulinic acid early invasive oral cancer topical photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1991790210600062 |
| work_keys_str_mv | AT hsinmingchen successfultreatmentofanearlyinvasiveoralsquamouscellcarcinomawithtopical5aminolevulinicacidmediatedphotodynamictherapy AT chuanhangyu successfultreatmentofanearlyinvasiveoralsquamouscellcarcinomawithtopical5aminolevulinicacidmediatedphotodynamictherapy AT hungpinlin successfultreatmentofanearlyinvasiveoralsquamouscellcarcinomawithtopical5aminolevulinicacidmediatedphotodynamictherapy AT hsiangyang successfultreatmentofanearlyinvasiveoralsquamouscellcarcinomawithtopical5aminolevulinicacidmediatedphotodynamictherapy AT ruchengkuo successfultreatmentofanearlyinvasiveoralsquamouscellcarcinomawithtopical5aminolevulinicacidmediatedphotodynamictherapy AT yingshiungkuo successfultreatmentofanearlyinvasiveoralsquamouscellcarcinomawithtopical5aminolevulinicacidmediatedphotodynamictherapy AT chunpinchiang successfultreatmentofanearlyinvasiveoralsquamouscellcarcinomawithtopical5aminolevulinicacidmediatedphotodynamictherapy |