HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income country
Current follow-up strategy for women after large loop excision of the transformation zone (LLETZ) for cervical intra-epithelial neoplasia (CIN) is burdened by a low compliance. We evaluated the performance of home-based Human Papillomavirus (HPV) self-sampling (Self-HPV) after treatment for CIN with...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335521002540 |
| _version_ | 1828902468070670336 |
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| author | Manuela Viviano Pierre Vassilakos Ulrike Meyer-Hamme Lorraine Grangier Shahzia Lambat Emery Manuela Undurraga Malinverno Patrick Petignat |
| author_facet | Manuela Viviano Pierre Vassilakos Ulrike Meyer-Hamme Lorraine Grangier Shahzia Lambat Emery Manuela Undurraga Malinverno Patrick Petignat |
| author_sort | Manuela Viviano |
| collection | DOAJ |
| description | Current follow-up strategy for women after large loop excision of the transformation zone (LLETZ) for cervical intra-epithelial neoplasia (CIN) is burdened by a low compliance. We evaluated the performance of home-based Human Papillomavirus (HPV) self-sampling (Self-HPV) after treatment for CIN with the aim to assess the (i) feasibility and (ii) follow-up compliance. This study took place at the Geneva University Hospitals between May 2016 and September 2020. Women aged 18 years or older, undergoing LLETZ for a biopsy-proven cervical intraepithelial neoplasia grade 1 or worse (CIN1 + ) were invited to participate. Agreement statistics, interpreted according to the scale of κ values, were calculated for Self-HPV and HPV performed by the physician (Dr-HPV). The samples were analyzed using GeneXpert and Cobas. Sample size was calculated to provide a 10% precision to estimate the kappa coefficient. A total of 127 women were included, with a median age of 35 years (interquartile range 30–41 years). There was a substantial agreement between Self-HPV and Dr-HPV using GeneXpert at 6 and 12 months, with a κ value of 0.63 (95%CI: 0.47–0.79) and 0.66 (95%CI: 0.50–0.82), respectively. Up to 9/10 (90%) women who did not come to their follow-up visit did not send their Self-HPV, either. In the follow-up after LLETZ treatment, home-based self-HPV is feasible, with substantial agreement between the two groups, however, concern remains regarding adherence to Self-HPV performance at home and loss to follow-up.The trial was registered on clinicaltrials.gov with the identifier NCT02780960. |
| first_indexed | 2024-12-13T16:16:56Z |
| format | Article |
| id | doaj.art-c1e00ad275e94fe3864ef71727a374b3 |
| institution | Directory Open Access Journal |
| issn | 2211-3355 |
| language | English |
| last_indexed | 2024-12-13T16:16:56Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj.art-c1e00ad275e94fe3864ef71727a374b32022-12-21T23:38:49ZengElsevierPreventive Medicine Reports2211-33552021-12-0124101564HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income countryManuela Viviano0Pierre Vassilakos1Ulrike Meyer-Hamme2Lorraine Grangier3Shahzia Lambat Emery4Manuela Undurraga Malinverno5Patrick Petignat6Gynecology Division, Geneva University Hospitals, Geneva, Switzerland; Corresponding author at: Geneva University Hospitals, Boulevard de la Cluse 30, 1205 Genève, Switzerland.Gynecology Division, Geneva University Hospitals, Geneva, Switzerland; Geneva Foundation for Medical Research, Geneva, SwitzerlandGynecology Division, Geneva University Hospitals, Geneva, SwitzerlandGynecology Division, Geneva University Hospitals, Geneva, SwitzerlandGynecology Division, Geneva University Hospitals, Geneva, SwitzerlandGynecology Division, Geneva University Hospitals, Geneva, SwitzerlandGynecology Division, Geneva University Hospitals, Geneva, SwitzerlandCurrent follow-up strategy for women after large loop excision of the transformation zone (LLETZ) for cervical intra-epithelial neoplasia (CIN) is burdened by a low compliance. We evaluated the performance of home-based Human Papillomavirus (HPV) self-sampling (Self-HPV) after treatment for CIN with the aim to assess the (i) feasibility and (ii) follow-up compliance. This study took place at the Geneva University Hospitals between May 2016 and September 2020. Women aged 18 years or older, undergoing LLETZ for a biopsy-proven cervical intraepithelial neoplasia grade 1 or worse (CIN1 + ) were invited to participate. Agreement statistics, interpreted according to the scale of κ values, were calculated for Self-HPV and HPV performed by the physician (Dr-HPV). The samples were analyzed using GeneXpert and Cobas. Sample size was calculated to provide a 10% precision to estimate the kappa coefficient. A total of 127 women were included, with a median age of 35 years (interquartile range 30–41 years). There was a substantial agreement between Self-HPV and Dr-HPV using GeneXpert at 6 and 12 months, with a κ value of 0.63 (95%CI: 0.47–0.79) and 0.66 (95%CI: 0.50–0.82), respectively. Up to 9/10 (90%) women who did not come to their follow-up visit did not send their Self-HPV, either. In the follow-up after LLETZ treatment, home-based self-HPV is feasible, with substantial agreement between the two groups, however, concern remains regarding adherence to Self-HPV performance at home and loss to follow-up.The trial was registered on clinicaltrials.gov with the identifier NCT02780960.http://www.sciencedirect.com/science/article/pii/S2211335521002540Cervical cancerCervical intraepithelial neoplasiaLLETZScreeningHPV self-sampling |
| spellingShingle | Manuela Viviano Pierre Vassilakos Ulrike Meyer-Hamme Lorraine Grangier Shahzia Lambat Emery Manuela Undurraga Malinverno Patrick Petignat HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income country Preventive Medicine Reports Cervical cancer Cervical intraepithelial neoplasia LLETZ Screening HPV self-sampling |
| title | HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income country |
| title_full | HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income country |
| title_fullStr | HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income country |
| title_full_unstemmed | HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income country |
| title_short | HPV self-sampling in the follow-up of women after treatment of cervical intra-epithelial neoplasia: A prospective study in a high-income country |
| title_sort | hpv self sampling in the follow up of women after treatment of cervical intra epithelial neoplasia a prospective study in a high income country |
| topic | Cervical cancer Cervical intraepithelial neoplasia LLETZ Screening HPV self-sampling |
| url | http://www.sciencedirect.com/science/article/pii/S2211335521002540 |
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