Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers
For many years, luteinizing hormone-releasing hormone or gonadotropin-releasing hormone (GnRH) analogs have been used to treat androgen or estrogen-dependent tumors. However, emerging evidence shows that the GnRH receptor (GnRH-R) is overexpressed in several cancer cells, including ovarian, endometr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1143261/full |
| _version_ | 1827978507826757632 |
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| author | Maritza P. Garrido Maritza P. Garrido Andrea Hernandez Margarita Vega Margarita Vega Eyleen Araya Carmen Romero Carmen Romero |
| author_facet | Maritza P. Garrido Maritza P. Garrido Andrea Hernandez Margarita Vega Margarita Vega Eyleen Araya Carmen Romero Carmen Romero |
| author_sort | Maritza P. Garrido |
| collection | DOAJ |
| description | For many years, luteinizing hormone-releasing hormone or gonadotropin-releasing hormone (GnRH) analogs have been used to treat androgen or estrogen-dependent tumors. However, emerging evidence shows that the GnRH receptor (GnRH-R) is overexpressed in several cancer cells, including ovarian, endometrial, and prostate cancer cells, suggesting that GnRH analogs could exert direct antitumoral actions in tumoral tissues that express GnRH-R. Another recent approach based on this knowledge was the use of GnRH peptides for developing specific targeted therapies, improving the delivery and accumulation of drugs in tumoral cells, and decreasing most side effects of current treatments. In this review, we discuss the conventional uses of GnRH analogs, together with the recent advances in GnRH-based drug delivery for ovarian, breast, and prostatic cancer cells. |
| first_indexed | 2024-04-09T21:23:03Z |
| format | Article |
| id | doaj.art-c1e273e37b954cfd9aef10d15200b113 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T21:23:03Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-c1e273e37b954cfd9aef10d15200b1132023-03-28T04:43:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11432611143261Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancersMaritza P. Garrido0Maritza P. Garrido1Andrea Hernandez2Margarita Vega3Margarita Vega4Eyleen Araya5Carmen Romero6Carmen Romero7Laboratorio de Endocrinología y Biología de la Reproducción, Hospital Clínico Universidad de Chile, Santiago, ChileDepartamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Santiago, ChileLaboratorio de Endocrinología y Biología de la Reproducción, Hospital Clínico Universidad de Chile, Santiago, ChileLaboratorio de Endocrinología y Biología de la Reproducción, Hospital Clínico Universidad de Chile, Santiago, ChileDepartamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Santiago, ChileDepartamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, ChileLaboratorio de Endocrinología y Biología de la Reproducción, Hospital Clínico Universidad de Chile, Santiago, ChileDepartamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Santiago, ChileFor many years, luteinizing hormone-releasing hormone or gonadotropin-releasing hormone (GnRH) analogs have been used to treat androgen or estrogen-dependent tumors. However, emerging evidence shows that the GnRH receptor (GnRH-R) is overexpressed in several cancer cells, including ovarian, endometrial, and prostate cancer cells, suggesting that GnRH analogs could exert direct antitumoral actions in tumoral tissues that express GnRH-R. Another recent approach based on this knowledge was the use of GnRH peptides for developing specific targeted therapies, improving the delivery and accumulation of drugs in tumoral cells, and decreasing most side effects of current treatments. In this review, we discuss the conventional uses of GnRH analogs, together with the recent advances in GnRH-based drug delivery for ovarian, breast, and prostatic cancer cells.https://www.frontiersin.org/articles/10.3389/fendo.2023.1143261/fullGnRHtargeted therapyovarian cancerbreast cancerprostatic cancer |
| spellingShingle | Maritza P. Garrido Maritza P. Garrido Andrea Hernandez Margarita Vega Margarita Vega Eyleen Araya Carmen Romero Carmen Romero Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers Frontiers in Endocrinology GnRH targeted therapy ovarian cancer breast cancer prostatic cancer |
| title | Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers |
| title_full | Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers |
| title_fullStr | Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers |
| title_full_unstemmed | Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers |
| title_short | Conventional and new proposals of GnRH therapy for ovarian, breast, and prostatic cancers |
| title_sort | conventional and new proposals of gnrh therapy for ovarian breast and prostatic cancers |
| topic | GnRH targeted therapy ovarian cancer breast cancer prostatic cancer |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1143261/full |
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