Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3<i>H</i>)-Ones with Antiproliferative Activities

Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3<i>H</i>)-Ones with Antiproliferative Activities

Sixteen new 2-substituted quinazolines were synthesized using a straightforward methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid. The anti-proliferative activity of the target compounds was evaluated against nine cancer cell lines. Additionally, all the compounds were scr...

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Bibliographic Details
Main Authors: Maria Karelou, Dionysis Kampasis, Amalia D. Kalampaliki, Leentje Persoons, Andreas Krämer, Dominique Schols, Stefan Knapp, Steven De Jonghe, Ioannis K. Kostakis
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
quinazolines
synthesis
anti-proliferative activity
kinase inhibition
Online Access:https://www.mdpi.com/1420-3049/28/23/7912

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