Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations)
Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin electrophoresis. Silent mutations on β-gl...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences and Health Services
2017-05-01
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| Series: | Research in Molecular Medicine |
| Subjects: | |
| Online Access: | http://rmm.mazums.ac.ir/browse.php?a_code=A-10-856-2&slc_lang=en&sid=1 |
| _version_ | 1811210265154289664 |
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| author | Hossein Karami Hossein Jalali Mehrad Mahdavi Mohammad Reza Mahdavi |
| author_facet | Hossein Karami Hossein Jalali Mehrad Mahdavi Mohammad Reza Mahdavi |
| author_sort | Hossein Karami |
| collection | DOAJ |
| description | Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin electrophoresis. Silent mutations on β-globin gene have borderline or normal hematological indices that cannot be detected in premarital screening.
Material and Methods: A 4 years old boy affected with β-thalassemia was referred to the lab for molecular analysis. During the screening program for β-thalassemia, his father and mother were diagnosed as α and β-thalassemia carrier respectively.
Results: The results of molecular analysis showed that in addition to the α-globin single gene deletion (α3.7) the father have also carried a silent mutation on his β-globin gene named HBB c.82G>T or Hb Knossos that was missed in screening program.
Conclusion: The presented case shows that using CBC and hemoglobin electrophoresis in premarital screening program for detecting β-thalassemia carriers is not a valid approach and individuals who are carriers of silent β-globin gene mutations are missed in this procedure. Hence, in premarital screening program precise molecular investigation especially when the partner is a typical β-thalassemia carrier is recommended. |
| first_indexed | 2024-04-12T04:51:40Z |
| format | Article |
| id | doaj.art-c1e3739f5ec44ffda1bb4652abf25ab8 |
| institution | Directory Open Access Journal |
| issn | 2322-1348 2322-133X |
| language | English |
| last_indexed | 2024-04-12T04:51:40Z |
| publishDate | 2017-05-01 |
| publisher | Mazandaran University of Medical Sciences and Health Services |
| record_format | Article |
| series | Research in Molecular Medicine |
| spelling | doaj.art-c1e3739f5ec44ffda1bb4652abf25ab82022-12-22T03:47:16ZengMazandaran University of Medical Sciences and Health ServicesResearch in Molecular Medicine2322-13482322-133X2017-05-01523436Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations)Hossein Karami0Hossein Jalali1Mehrad Mahdavi2Mohammad Reza Mahdavi3 Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Students Research Committee, Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Sina Mehr Research Center, Sari, Iran Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin electrophoresis. Silent mutations on β-globin gene have borderline or normal hematological indices that cannot be detected in premarital screening. Material and Methods: A 4 years old boy affected with β-thalassemia was referred to the lab for molecular analysis. During the screening program for β-thalassemia, his father and mother were diagnosed as α and β-thalassemia carrier respectively. Results: The results of molecular analysis showed that in addition to the α-globin single gene deletion (α3.7) the father have also carried a silent mutation on his β-globin gene named HBB c.82G>T or Hb Knossos that was missed in screening program. Conclusion: The presented case shows that using CBC and hemoglobin electrophoresis in premarital screening program for detecting β-thalassemia carriers is not a valid approach and individuals who are carriers of silent β-globin gene mutations are missed in this procedure. Hence, in premarital screening program precise molecular investigation especially when the partner is a typical β-thalassemia carrier is recommended.http://rmm.mazums.ac.ir/browse.php?a_code=A-10-856-2&slc_lang=en&sid=1β-thalassemia Hb Knossos Premarital screening |
| spellingShingle | Hossein Karami Hossein Jalali Mehrad Mahdavi Mohammad Reza Mahdavi Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations) Research in Molecular Medicine β-thalassemia Hb Knossos Premarital screening |
| title | Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations) |
| title_full | Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations) |
| title_fullStr | Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations) |
| title_full_unstemmed | Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations) |
| title_short | Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations) |
| title_sort | identification of a neonate with thalassemia intermedia despite premarital screening program in mazandaran province co inheritance of hb knossos and ivs ii 1 g a mutations |
| topic | β-thalassemia Hb Knossos Premarital screening |
| url | http://rmm.mazums.ac.ir/browse.php?a_code=A-10-856-2&slc_lang=en&sid=1 |
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