| Summary: | <i>Background and objectives</i>: The aim of this study was to research oxidative stress and thiol/disulphide homeostasis in Graves’ patients. <i>Materials and Methods</i>: The study included 33 Graves’ patients (research group) and 35 healthy subjects (control group). Serum oxidative stress and thiol/disulphide homeostasis (a new and automated spectrophotometric method developed by Erel and Neselioglu) parameters were studied and compared between the groups. <i>Results:</i> The native and total thiol levels and the native thiol/total thiol ratio were lower in patients with Graves’ disease compared to the control group (<i>p</i> < 0.001, <i>p</i> < 0.001, and <i>p</i> = 0.006, respectively). TOS (total antioxidant status), PC (protein carbonyl), OSI (Oxidative stress index), and disulphide/native thiol and disulphide/total thiol ratios were determined to be higher in the Graves’ disease group than in the control group (<i>p</i> < 0.001, <i>p</i> = 0.001, <i>p</i> = 0.001, <i>p</i> = 0.004, and <i>p</i> = 0.006, respectively). In the Graves’ disease group, the free triiodothyronine (FT3) and free thyroxine (FT4) levels were significantly positively correlated with impaired thiol/disulphide homeostasis and oxidative stress parameters (<i>p</i> < 0.05). <i>Conclusion</i>: The results of the current study demonstrated that oxidative stress and thiol/disulphide homeostasis increased towards disulphide formation due to thiol oxidation in Graves’ disease. In addition, a positive correlation of FT3 and FT4 was observed with oxidative stress parameters and impaired thiol/disulphide homeostasis.
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