Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature
Abstract Background Medullary carcinoma of the colon is a rare subtype of colorectal cancer that has a unique, and sometimes varied, clinical and histologic profile. It usually presents in adult patients older than 50 years. Here, we report a unique case of young male patient who initially presented...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-023-04160-0 |
| _version_ | 1797452542952603648 |
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| author | Fajer Al-Ishaq Mahmood Al-Dhaheri Ali Toffaha Salwa Awad Syed Rizvi Mohamed AbuNada Mohamed Kurer |
| author_facet | Fajer Al-Ishaq Mahmood Al-Dhaheri Ali Toffaha Salwa Awad Syed Rizvi Mohamed AbuNada Mohamed Kurer |
| author_sort | Fajer Al-Ishaq |
| collection | DOAJ |
| description | Abstract Background Medullary carcinoma of the colon is a rare subtype of colorectal cancer that has a unique, and sometimes varied, clinical and histologic profile. It usually presents in adult patients older than 50 years. Here, we report a unique case of young male patient who initially presented with abdominal pain followed by a large bowel obstruction. Case presentation A 40-year-old SriLankan male presented with right-sided abdominal pain and on examination, there was a palpable right iliac fossa mass. Colonoscopy and a computed tomography scan revealed cecal mass. Later, while waiting for elective resection, the patient developed symptoms and signs of a large bowel obstruction. He underwent a laparoscopic right hemicolectomy with an uneventful postoperative course. The histopathologic evaluation of the resected specimens showed invasive carcinoma with syncytial growth pattern, foci of lymphoid host response, and dirty necrosis, in keeping with a medullary carcinoma pT4a pN2b. Unlike most reported medullary carcinoma cases, this patient was young and caudal-related homeobox transcription factor 2 positive. Conclusion We have reported another case of medullary carcinoma of the colon in a young patient with unique histologic characteristics. Reporting such cases helps in refine understanding of the histologic and genetic, as well as clinical, phenotypes of medullary carcinoma of the colon. |
| first_indexed | 2024-03-09T15:10:13Z |
| format | Article |
| id | doaj.art-c1e5d6ea0023464ba3066046a54def0b |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-09T15:10:13Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-c1e5d6ea0023464ba3066046a54def0b2023-11-26T13:26:25ZengBMCJournal of Medical Case Reports1752-19472023-10-011711710.1186/s13256-023-04160-0Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literatureFajer Al-Ishaq0Mahmood Al-Dhaheri1Ali Toffaha2Salwa Awad3Syed Rizvi4Mohamed AbuNada5Mohamed Kurer6Colorectal Surgery Unit, Hamad Medical CorporationColorectal Surgery Unit, Hamad Medical CorporationColorectal Surgery Unit, Hamad Medical CorporationColorectal Surgery Unit, Hamad Medical CorporationLaboratory and Pathology Department, Hamad Medical CorporationColorectal Surgery Unit, Hamad Medical CorporationColorectal Surgery Unit, Hamad Medical CorporationAbstract Background Medullary carcinoma of the colon is a rare subtype of colorectal cancer that has a unique, and sometimes varied, clinical and histologic profile. It usually presents in adult patients older than 50 years. Here, we report a unique case of young male patient who initially presented with abdominal pain followed by a large bowel obstruction. Case presentation A 40-year-old SriLankan male presented with right-sided abdominal pain and on examination, there was a palpable right iliac fossa mass. Colonoscopy and a computed tomography scan revealed cecal mass. Later, while waiting for elective resection, the patient developed symptoms and signs of a large bowel obstruction. He underwent a laparoscopic right hemicolectomy with an uneventful postoperative course. The histopathologic evaluation of the resected specimens showed invasive carcinoma with syncytial growth pattern, foci of lymphoid host response, and dirty necrosis, in keeping with a medullary carcinoma pT4a pN2b. Unlike most reported medullary carcinoma cases, this patient was young and caudal-related homeobox transcription factor 2 positive. Conclusion We have reported another case of medullary carcinoma of the colon in a young patient with unique histologic characteristics. Reporting such cases helps in refine understanding of the histologic and genetic, as well as clinical, phenotypes of medullary carcinoma of the colon.https://doi.org/10.1186/s13256-023-04160-0Colon cancerMedullary carcinomaMicrosatellite instabilityImmunohistochemistry |
| spellingShingle | Fajer Al-Ishaq Mahmood Al-Dhaheri Ali Toffaha Salwa Awad Syed Rizvi Mohamed AbuNada Mohamed Kurer Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature Journal of Medical Case Reports Colon cancer Medullary carcinoma Microsatellite instability Immunohistochemistry |
| title | Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature |
| title_full | Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature |
| title_fullStr | Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature |
| title_full_unstemmed | Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature |
| title_short | Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature |
| title_sort | colonic medullary carcinoma an exceedingly rare type of colorectal malignancy a case report and review of the literature |
| topic | Colon cancer Medullary carcinoma Microsatellite instability Immunohistochemistry |
| url | https://doi.org/10.1186/s13256-023-04160-0 |
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