Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis
Marek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first tha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/3/647 |
| _version_ | 1797726039229595648 |
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| author | Luca D. Bertzbach Andelé M. Conradie Yu You Benedikt B. Kaufer |
| author_facet | Luca D. Bertzbach Andelé M. Conradie Yu You Benedikt B. Kaufer |
| author_sort | Luca D. Bertzbach |
| collection | DOAJ |
| description | Marek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first that prevented cancer and minimized the losses in the poultry industry. Even though the current gold standard vaccine efficiently protects against clinical disease, the virus continuously evolves towards higher virulence. Emerging field strains were able to overcome the protection provided by the previous two vaccine generations. Research over the last few years revealed important insights into the virus life cycle, cellular tropism, and tumor development that are summarized in this review. In addition, we discuss recent data on the MDV transcriptome, the constant evolution of this highly oncogenic virus towards higher virulence, and future perspectives in MDV research. |
| first_indexed | 2024-03-12T10:40:03Z |
| format | Article |
| id | doaj.art-c1e938c030b8413792e2eeec99ff3ef2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:40:03Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c1e938c030b8413792e2eeec99ff3ef22023-09-02T08:16:57ZengMDPI AGCancers2072-66942020-03-0112364710.3390/cancers12030647cancers12030647Latest Insights into Marek’s Disease Virus Pathogenesis and TumorigenesisLuca D. Bertzbach0Andelé M. Conradie1Yu You2Benedikt B. Kaufer3Institut für Virologie, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, GermanyInstitut für Virologie, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, GermanyInstitut für Virologie, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, GermanyInstitut für Virologie, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, GermanyMarek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first that prevented cancer and minimized the losses in the poultry industry. Even though the current gold standard vaccine efficiently protects against clinical disease, the virus continuously evolves towards higher virulence. Emerging field strains were able to overcome the protection provided by the previous two vaccine generations. Research over the last few years revealed important insights into the virus life cycle, cellular tropism, and tumor development that are summarized in this review. In addition, we discuss recent data on the MDV transcriptome, the constant evolution of this highly oncogenic virus towards higher virulence, and future perspectives in MDV research.https://www.mdpi.com/2072-6694/12/3/647lymphomaavian cancerherpesvirusmarek’s disease virusvaccinelife cyclecell tropism |
| spellingShingle | Luca D. Bertzbach Andelé M. Conradie Yu You Benedikt B. Kaufer Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis Cancers lymphoma avian cancer herpesvirus marek’s disease virus vaccine life cycle cell tropism |
| title | Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis |
| title_full | Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis |
| title_fullStr | Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis |
| title_full_unstemmed | Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis |
| title_short | Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis |
| title_sort | latest insights into marek s disease virus pathogenesis and tumorigenesis |
| topic | lymphoma avian cancer herpesvirus marek’s disease virus vaccine life cycle cell tropism |
| url | https://www.mdpi.com/2072-6694/12/3/647 |
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