Structural and functional brain changes beyond visual system in patients with advanced glaucoma.
In order to test the hypothesis that in primary open angle glaucoma (POAG), an important cause of irreversible blindness, a spreading of neurodegeneration occurs through the brain, we performed multimodal MRI and subsequent whole-brain explorative voxelwise analyses in 13 advanced POAG patients and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4146554?pdf=render |
| _version_ | 1811235554472230912 |
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| author | Paolo Frezzotti Antonio Giorgio Ilaria Motolese Alessandro De Leucio Michele Iester Eduardo Motolese Antonio Federico Nicola De Stefano |
| author_facet | Paolo Frezzotti Antonio Giorgio Ilaria Motolese Alessandro De Leucio Michele Iester Eduardo Motolese Antonio Federico Nicola De Stefano |
| author_sort | Paolo Frezzotti |
| collection | DOAJ |
| description | In order to test the hypothesis that in primary open angle glaucoma (POAG), an important cause of irreversible blindness, a spreading of neurodegeneration occurs through the brain, we performed multimodal MRI and subsequent whole-brain explorative voxelwise analyses in 13 advanced POAG patients and 12 age-matched normal controls (NC). Altered integrity (decreased fractional anisotropy or increased diffusivities) of white matter (WM) tracts was found not only along the visual pathway of POAG but also in nonvisual WM tracts (superior longitudinal fascicle, anterior thalamic radiation, corticospinal tract, middle cerebellar peduncle). POAG patients also showed brain atrophy in both visual cortex and other distant grey matter (GM) regions (frontoparietal cortex, hippocampi and cerebellar cortex), decreased functional connectivity (FC) in visual, working memory and dorsal attention networks and increased FC in visual and executive networks. In POAG, abnormalities in structure and FC within and outside visual system correlated with visual field parameters in the poorer performing eyes, thus emphasizing their clinical relevance. Altogether, this represents evidence that a vision disorder such as POAG can be considered a widespread neurodegenerative condition. |
| first_indexed | 2024-04-12T11:54:08Z |
| format | Article |
| id | doaj.art-c1eb9f27b6234d26a11c558542be65ec |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T11:54:08Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c1eb9f27b6234d26a11c558542be65ec2022-12-22T03:34:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10593110.1371/journal.pone.0105931Structural and functional brain changes beyond visual system in patients with advanced glaucoma.Paolo FrezzottiAntonio GiorgioIlaria MotoleseAlessandro De LeucioMichele IesterEduardo MotoleseAntonio FedericoNicola De StefanoIn order to test the hypothesis that in primary open angle glaucoma (POAG), an important cause of irreversible blindness, a spreading of neurodegeneration occurs through the brain, we performed multimodal MRI and subsequent whole-brain explorative voxelwise analyses in 13 advanced POAG patients and 12 age-matched normal controls (NC). Altered integrity (decreased fractional anisotropy or increased diffusivities) of white matter (WM) tracts was found not only along the visual pathway of POAG but also in nonvisual WM tracts (superior longitudinal fascicle, anterior thalamic radiation, corticospinal tract, middle cerebellar peduncle). POAG patients also showed brain atrophy in both visual cortex and other distant grey matter (GM) regions (frontoparietal cortex, hippocampi and cerebellar cortex), decreased functional connectivity (FC) in visual, working memory and dorsal attention networks and increased FC in visual and executive networks. In POAG, abnormalities in structure and FC within and outside visual system correlated with visual field parameters in the poorer performing eyes, thus emphasizing their clinical relevance. Altogether, this represents evidence that a vision disorder such as POAG can be considered a widespread neurodegenerative condition.http://europepmc.org/articles/PMC4146554?pdf=render |
| spellingShingle | Paolo Frezzotti Antonio Giorgio Ilaria Motolese Alessandro De Leucio Michele Iester Eduardo Motolese Antonio Federico Nicola De Stefano Structural and functional brain changes beyond visual system in patients with advanced glaucoma. PLoS ONE |
| title | Structural and functional brain changes beyond visual system in patients with advanced glaucoma. |
| title_full | Structural and functional brain changes beyond visual system in patients with advanced glaucoma. |
| title_fullStr | Structural and functional brain changes beyond visual system in patients with advanced glaucoma. |
| title_full_unstemmed | Structural and functional brain changes beyond visual system in patients with advanced glaucoma. |
| title_short | Structural and functional brain changes beyond visual system in patients with advanced glaucoma. |
| title_sort | structural and functional brain changes beyond visual system in patients with advanced glaucoma |
| url | http://europepmc.org/articles/PMC4146554?pdf=render |
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