Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, Egypt
Mohamed Salaheldeen Noor,1 Magdy Elbarbary,2 Sherif N Embabi,1 Mohamed A Zaki,1 Hisham Awad,1 Mariam Al-Feky1 1Ophthalmology Department, Ain Shams University, Cairo, Egypt; 2Paediatrics Department, Ain Shams University, Cairo, EgyptCorrespondence: Mohamed Salaheldeen Noor, Ophthalmology Department,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-10-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/screening-and-risk-factors-for-retinopathy-of-prematurity-in-a-tertiar-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797998466638544896 |
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| author | Noor MS Elbarbary M Embabi SN Zaki MA Awad H Al-Feky M |
| author_facet | Noor MS Elbarbary M Embabi SN Zaki MA Awad H Al-Feky M |
| author_sort | Noor MS |
| collection | DOAJ |
| description | Mohamed Salaheldeen Noor,1 Magdy Elbarbary,2 Sherif N Embabi,1 Mohamed A Zaki,1 Hisham Awad,1 Mariam Al-Feky1 1Ophthalmology Department, Ain Shams University, Cairo, Egypt; 2Paediatrics Department, Ain Shams University, Cairo, EgyptCorrespondence: Mohamed Salaheldeen Noor, Ophthalmology Department, Ain Shams University, 22 Abdullah Ibn Eltaher street, Makram Edeid, Nasr city, Cairo, Egypt, Tel +201093769896, Email msn198840@gmail.comPurpose: To evaluate the retinopathy of prematurity (ROP) prevalence, risk factors and screening outcome in a tertiary hospital in Cairo, Egypt.Methods: A prospective observational study was done in Neonatal Intensive Care Unit in Ain Shams University Hospital. A total of 159 premature infants were screened for ROP based on the most inclusive criteria reported to date. Screening included premature infants with gestational age (GA) of ≤ 34 weeks or birth weight (BW) of ≤ 2000 grams, or GA > 34 weeks or BW > 2000 grams, with multiple co-morbidities. The prevalence of ROP, plus disease and their correlation with risk factors of interest were studied.Results: The GA of the included infants ranged from 27 to 36 weeks, mean (SD) 31.87 (± 1.81) weeks. The BW ranged from 640 to 3900 grams, mean (SD) 1784.71 (± 560.30) grams. The prevalence of ROP more than stage 0 was 25.8% (41 infants), 7.3% of the cases (11 infants) showed plus disease and 6.3% (10 infants) showed severe ROP requiring treatment. Of those, 2 cases (20%) fell outside the British Guideline’s criteria for Screening. There was a highly significant (p < 0.0001) correlation between ROP more than stage 0 and low GA, low BW, mechanical ventilation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular haemorrhage, and blood transfusion. No significant correlation was found between appearance of ROP more than stage 0 and gender (p = 0.911), patent ductus arteriosus (p =0.187), or sepsis (p =0.998).Conclusion: ROP is a significant problem in the premature infants in Egypt. Extremely premature infants with lower BW are more prone to develop ROP. However, cases with higher GA and BW than mentioned in the British guidelines screening criteria especially with multiple comorbidities showed severe ROP requiring intervention, which implies the need to develop a screening guideline for the Egyptian population.Keywords: retinopathy of prematurity, screening, risk factors, epidemiology, prematurity |
| first_indexed | 2024-04-11T10:49:10Z |
| format | Article |
| id | doaj.art-c1ee36cb13a04769b7f7741aa59759f8 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-04-11T10:49:10Z |
| publishDate | 2022-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-c1ee36cb13a04769b7f7741aa59759f82022-12-22T04:28:58ZengDove Medical PressClinical Ophthalmology1177-54832022-10-01Volume 163257326778708Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, EgyptNoor MSElbarbary MEmbabi SNZaki MAAwad HAl-Feky MMohamed Salaheldeen Noor,1 Magdy Elbarbary,2 Sherif N Embabi,1 Mohamed A Zaki,1 Hisham Awad,1 Mariam Al-Feky1 1Ophthalmology Department, Ain Shams University, Cairo, Egypt; 2Paediatrics Department, Ain Shams University, Cairo, EgyptCorrespondence: Mohamed Salaheldeen Noor, Ophthalmology Department, Ain Shams University, 22 Abdullah Ibn Eltaher street, Makram Edeid, Nasr city, Cairo, Egypt, Tel +201093769896, Email msn198840@gmail.comPurpose: To evaluate the retinopathy of prematurity (ROP) prevalence, risk factors and screening outcome in a tertiary hospital in Cairo, Egypt.Methods: A prospective observational study was done in Neonatal Intensive Care Unit in Ain Shams University Hospital. A total of 159 premature infants were screened for ROP based on the most inclusive criteria reported to date. Screening included premature infants with gestational age (GA) of ≤ 34 weeks or birth weight (BW) of ≤ 2000 grams, or GA > 34 weeks or BW > 2000 grams, with multiple co-morbidities. The prevalence of ROP, plus disease and their correlation with risk factors of interest were studied.Results: The GA of the included infants ranged from 27 to 36 weeks, mean (SD) 31.87 (± 1.81) weeks. The BW ranged from 640 to 3900 grams, mean (SD) 1784.71 (± 560.30) grams. The prevalence of ROP more than stage 0 was 25.8% (41 infants), 7.3% of the cases (11 infants) showed plus disease and 6.3% (10 infants) showed severe ROP requiring treatment. Of those, 2 cases (20%) fell outside the British Guideline’s criteria for Screening. There was a highly significant (p < 0.0001) correlation between ROP more than stage 0 and low GA, low BW, mechanical ventilation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular haemorrhage, and blood transfusion. No significant correlation was found between appearance of ROP more than stage 0 and gender (p = 0.911), patent ductus arteriosus (p =0.187), or sepsis (p =0.998).Conclusion: ROP is a significant problem in the premature infants in Egypt. Extremely premature infants with lower BW are more prone to develop ROP. However, cases with higher GA and BW than mentioned in the British guidelines screening criteria especially with multiple comorbidities showed severe ROP requiring intervention, which implies the need to develop a screening guideline for the Egyptian population.Keywords: retinopathy of prematurity, screening, risk factors, epidemiology, prematurityhttps://www.dovepress.com/screening-and-risk-factors-for-retinopathy-of-prematurity-in-a-tertiar-peer-reviewed-fulltext-article-OPTHretinopathy of prematurityscreeningrisk factorsepidemiologyprematurity |
| spellingShingle | Noor MS Elbarbary M Embabi SN Zaki MA Awad H Al-Feky M Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, Egypt Clinical Ophthalmology retinopathy of prematurity screening risk factors epidemiology prematurity |
| title | Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, Egypt |
| title_full | Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, Egypt |
| title_fullStr | Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, Egypt |
| title_full_unstemmed | Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, Egypt |
| title_short | Screening and Risk Factors for Retinopathy of Prematurity in a Tertiary Care Hospital in Cairo, Egypt |
| title_sort | screening and risk factors for retinopathy of prematurity in a tertiary care hospital in cairo egypt |
| topic | retinopathy of prematurity screening risk factors epidemiology prematurity |
| url | https://www.dovepress.com/screening-and-risk-factors-for-retinopathy-of-prematurity-in-a-tertiar-peer-reviewed-fulltext-article-OPTH |
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