Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/Amikacin
Ventilator-associated pneumonia (VAP) is a common nosocomial infection in the intensive care unit (ICU). This study was performed in the Reanimation and Emergency ICUs of the Ankara D›flkap› Education and Research Hospital between January 1997 and January 2000. In a randomized, prospective trial, we...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2006-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2006-11-2-096-101.pdf |
| _version_ | 1797911077434949632 |
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| author | Ahmet ELALDI Canan AĞALAR Tuna DEMİRDAL Murat SAYIN Rüçhan TÜRKYILMAZ |
| author_facet | Ahmet ELALDI Canan AĞALAR Tuna DEMİRDAL Murat SAYIN Rüçhan TÜRKYILMAZ |
| author_sort | Ahmet ELALDI |
| collection | DOAJ |
| description | Ventilator-associated pneumonia (VAP) is a common nosocomial infection in the intensive care unit (ICU). This study was performed in the Reanimation and Emergency ICUs of the Ankara D›flkap› Education and Research Hospital between January 1997 and January 2000. In a randomized, prospective trial, we compared imipenem-cilastatin (500 mg four times a day) + amikacin (1 g single dose a day) with ticarcillin/clavulanate (3.1 g four times a day) + amikacin (1 g single dose a day) for the treatment of VAP in 35 adult ICU patients. In this study, there was no statistically significant difference between the mortality rates and risk factors of the group I patients and group II patients (p> 0.05). Our results demonstrate that in patients with VAP, there is no significant difference between combination therapy with ticarcillin-clavulanate/amikacin and imipenem-cilastatin/amikacin in terms of bacteriological eradication and clinical response. |
| first_indexed | 2024-04-10T11:34:34Z |
| format | Article |
| id | doaj.art-c1f264ae806043c5ac5f9dc111fec828 |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T11:34:34Z |
| publishDate | 2006-06-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-c1f264ae806043c5ac5f9dc111fec8282023-02-15T16:17:56ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2006-06-0111296101Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/AmikacinAhmet ELALDI0Canan AĞALAR1Tuna DEMİRDAL2Murat SAYIN3Rüçhan TÜRKYILMAZ4S.B. Dışkapı Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kliniği, ANKARAKırıkkale Üniversitesi Tıp Fakültesi, Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, KIRIKKALEKocatepe Üniversitesi Tıp Fakültesi, Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, AFYONS.B. Dışkapı Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kliniği, ANKARAS.B. Dışkapı Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kliniği, ANKARAVentilator-associated pneumonia (VAP) is a common nosocomial infection in the intensive care unit (ICU). This study was performed in the Reanimation and Emergency ICUs of the Ankara D›flkap› Education and Research Hospital between January 1997 and January 2000. In a randomized, prospective trial, we compared imipenem-cilastatin (500 mg four times a day) + amikacin (1 g single dose a day) with ticarcillin/clavulanate (3.1 g four times a day) + amikacin (1 g single dose a day) for the treatment of VAP in 35 adult ICU patients. In this study, there was no statistically significant difference between the mortality rates and risk factors of the group I patients and group II patients (p> 0.05). Our results demonstrate that in patients with VAP, there is no significant difference between combination therapy with ticarcillin-clavulanate/amikacin and imipenem-cilastatin/amikacin in terms of bacteriological eradication and clinical response.http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2006-11-2-096-101.pdfVentilator-associated pneumoniaIntensive care unitsTherapy |
| spellingShingle | Ahmet ELALDI Canan AĞALAR Tuna DEMİRDAL Murat SAYIN Rüçhan TÜRKYILMAZ Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/Amikacin Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Ventilator-associated pneumonia Intensive care units Therapy |
| title | Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/Amikacin |
| title_full | Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/Amikacin |
| title_fullStr | Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/Amikacin |
| title_full_unstemmed | Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/Amikacin |
| title_short | Treatment of Ventilator-Associated Gram-Negative Pneumonia with Imipenem-Cilastatin/Amikacin Versus Ticarcillin-Clavulanate/Amikacin |
| title_sort | treatment of ventilator associated gram negative pneumonia with imipenem cilastatin amikacin versus ticarcillin clavulanate amikacin |
| topic | Ventilator-associated pneumonia Intensive care units Therapy |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2006-11-2-096-101.pdf |
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