Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis
ObjectiveResearch data suggest that patients with Hashimoto’s thyroiditis may increase the risk of cancer. However, existing research is inconsistent with this view. Therefore, to investigate the effect of Hashimoto’s thyroiditis on the risk of developing cancer, we conducted this study.MethodsWe se...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.937871/full |
| _version_ | 1818108142842544128 |
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| author | Xiaojie Hu Xiaojie Hu Xuanyu Wang Yue Liang Xin Chen Siyuan Zhou Wenting Fei Yuxin Yang Huafa Que Huafa Que |
| author_facet | Xiaojie Hu Xiaojie Hu Xuanyu Wang Yue Liang Xin Chen Siyuan Zhou Wenting Fei Yuxin Yang Huafa Que Huafa Que |
| author_sort | Xiaojie Hu |
| collection | DOAJ |
| description | ObjectiveResearch data suggest that patients with Hashimoto’s thyroiditis may increase the risk of cancer. However, existing research is inconsistent with this view. Therefore, to investigate the effect of Hashimoto’s thyroiditis on the risk of developing cancer, we conducted this study.MethodsWe searched the PubMed and Embase databases from database establishment until March 2022. After rigorous literature screening by two authors, 23 studies that met the inclusion criteria were identified, and the required data were independently extracted.ResultsWe retrieved 3591 records, and after the screening, 11 case-control studies and 12 cohort studies were included in the analysis. Data analysis suggested that patients with Hashimoto’s thyroiditis had an increased risk of developing breast cancer, urogenital cancer, digestive organs cancer, hematologic cancer, and a low risk of respiratory cancers.ConclusionsThis systematic review and meta-analysis showed that patients with HT may have a significantly increased risk of thyroid cancer, breast cancers, lung cancer, digestive system cancer, urogenital cancers, blood cancers, and prolactinoma people without HT.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD 42022320741. |
| first_indexed | 2024-12-11T02:10:40Z |
| format | Article |
| id | doaj.art-c1f341851b0044eaae45ab419733d0b9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T02:10:40Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-c1f341851b0044eaae45ab419733d0b92022-12-22T01:24:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.937871937871Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-AnalysisXiaojie Hu0Xiaojie Hu1Xuanyu Wang2Yue Liang3Xin Chen4Siyuan Zhou5Wenting Fei6Yuxin Yang7Huafa Que8Huafa Que9Department of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Shanghai, ChinaObjectiveResearch data suggest that patients with Hashimoto’s thyroiditis may increase the risk of cancer. However, existing research is inconsistent with this view. Therefore, to investigate the effect of Hashimoto’s thyroiditis on the risk of developing cancer, we conducted this study.MethodsWe searched the PubMed and Embase databases from database establishment until March 2022. After rigorous literature screening by two authors, 23 studies that met the inclusion criteria were identified, and the required data were independently extracted.ResultsWe retrieved 3591 records, and after the screening, 11 case-control studies and 12 cohort studies were included in the analysis. Data analysis suggested that patients with Hashimoto’s thyroiditis had an increased risk of developing breast cancer, urogenital cancer, digestive organs cancer, hematologic cancer, and a low risk of respiratory cancers.ConclusionsThis systematic review and meta-analysis showed that patients with HT may have a significantly increased risk of thyroid cancer, breast cancers, lung cancer, digestive system cancer, urogenital cancers, blood cancers, and prolactinoma people without HT.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD 42022320741.https://www.frontiersin.org/articles/10.3389/fendo.2022.937871/fullHashimoto’s thyroiditiscancer riskobservational studysystematic reviewmeta-analysis |
| spellingShingle | Xiaojie Hu Xiaojie Hu Xuanyu Wang Yue Liang Xin Chen Siyuan Zhou Wenting Fei Yuxin Yang Huafa Que Huafa Que Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis Frontiers in Endocrinology Hashimoto’s thyroiditis cancer risk observational study systematic review meta-analysis |
| title | Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis |
| title_full | Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis |
| title_fullStr | Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis |
| title_full_unstemmed | Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis |
| title_short | Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis |
| title_sort | cancer risk in hashimoto s thyroiditis a systematic review and meta analysis |
| topic | Hashimoto’s thyroiditis cancer risk observational study systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.937871/full |
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