Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report
Myasthenia gravis is associated in 10 to 15 percent of patients with thymic tumors, rarely with aplastic anemia. We report a 45-year-old male diagnosed with myasthenia gravis associated with thymoma. We started treatment with pyridostigmine. After thymectomy, the patient received 30 irradiation se...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2017-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/288264 |
| _version_ | 1797207702180462592 |
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| author | Lidija Dežmalj Grbelja Radovan Vrhovac Monika Ulamec |
| author_facet | Lidija Dežmalj Grbelja Radovan Vrhovac Monika Ulamec |
| author_sort | Lidija Dežmalj Grbelja |
| collection | DOAJ |
| description | Myasthenia gravis is associated in 10 to 15 percent of patients with thymic tumors, rarely with aplastic anemia. We report a 45-year-old male diagnosed with myasthenia gravis associated with thymoma. We started treatment with pyridostigmine. After thymectomy, the patient received 30 irradiation sessions. In the postoperative course, he had mild worsening of myasthenia gravis, which improved with prednisone. Five months later, he developed severe aplastic anemia. He was dependent on blood supplement. After allogeneic transplantation of bone marrow, he improved but later he developed graft versus host disease. Myasthenia gravis was under good control with 480 mg of pyridostigmine per day. |
| first_indexed | 2024-04-24T09:27:06Z |
| format | Article |
| id | doaj.art-c1f3ad4c00854fc28b6dbc9003a35552 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:27:06Z |
| publishDate | 2017-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-c1f3ad4c00854fc28b6dbc9003a355522024-04-15T14:40:28ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512017-01-0156.4.81782010.20471/acc.2017.56.04.34Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case ReportLidija Dežmalj Grbelja0Radovan Vrhovac1Monika Ulamec2University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaUniversity Department of Hematology, Zagreb University Hospital Center, Zagreb, CroatiaUniversity Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaMyasthenia gravis is associated in 10 to 15 percent of patients with thymic tumors, rarely with aplastic anemia. We report a 45-year-old male diagnosed with myasthenia gravis associated with thymoma. We started treatment with pyridostigmine. After thymectomy, the patient received 30 irradiation sessions. In the postoperative course, he had mild worsening of myasthenia gravis, which improved with prednisone. Five months later, he developed severe aplastic anemia. He was dependent on blood supplement. After allogeneic transplantation of bone marrow, he improved but later he developed graft versus host disease. Myasthenia gravis was under good control with 480 mg of pyridostigmine per day.https://hrcak.srce.hr/file/288264Myasthenia gravisAnemia, aplasticThymomaPyridostigmine bromideThymectomyGraft vs host disease |
| spellingShingle | Lidija Dežmalj Grbelja Radovan Vrhovac Monika Ulamec Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report Acta Clinica Croatica Myasthenia gravis Anemia, aplastic Thymoma Pyridostigmine bromide Thymectomy Graft vs host disease |
| title | Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report |
| title_full | Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report |
| title_fullStr | Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report |
| title_full_unstemmed | Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report |
| title_short | Myasthenia Gravis Associated with Thymoma and Aplastic Anemia: Case Report |
| title_sort | myasthenia gravis associated with thymoma and aplastic anemia case report |
| topic | Myasthenia gravis Anemia, aplastic Thymoma Pyridostigmine bromide Thymectomy Graft vs host disease |
| url | https://hrcak.srce.hr/file/288264 |
| work_keys_str_mv | AT lidijadezmaljgrbelja myastheniagravisassociatedwiththymomaandaplasticanemiacasereport AT radovanvrhovac myastheniagravisassociatedwiththymomaandaplasticanemiacasereport AT monikaulamec myastheniagravisassociatedwiththymomaandaplasticanemiacasereport |