Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional study
Objective: Prolactin is correlated with some conditions that predispose individuals to atherosclerosis. Prolactin receptors have been found in atherosclerotic plaques. However, the correlation between the serum prolactin level and the extension and severity of coronary artery atherosclerosis has yet...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2019-04-01
|
| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-45213 |
| _version_ | 1797917893760909312 |
|---|---|
| author | Alireza Amirzadegan Elnaz Salimi Ali Hosseinsabet |
| author_facet | Alireza Amirzadegan Elnaz Salimi Ali Hosseinsabet |
| author_sort | Alireza Amirzadegan |
| collection | DOAJ |
| description | Objective: Prolactin is correlated with some conditions that predispose individuals to atherosclerosis. Prolactin receptors have been found in atherosclerotic plaques. However, the correlation between the serum prolactin level and the extension and severity of coronary artery atherosclerosis has yet to be studied.
Methods: In total, 414 postmenopausal women candidated for selective coronary angiography with normal serum prolactin levels were enrolled. The patients' lipid profile and levels of serum prolactin, thyroid-stimulating hormone, C-reactive protein, urea, creatinine, and fasting blood sugar were measured. The Gensini score for each patient was calculated. The study population was divided into 3 groups according to the tertile of the serum prolactin level.
Results: There was no statistically significant difference in terms of the Gensini score between the 3 groups in the univariate analysis (P = 0.075). The multivariable analysis showed that the serum prolactin level was not an independent determinant of the Gensini score (P = 0.430), whereas age, hypertension, diabetes and dyslipidemia were the independent determinants of the Gensini score.
Conclusions: There was no statistically significant correlation between the serum prolactin level and coronary artery atherosclerosis expressed as the Gensini score in our sample of postmenopausal women. |
| first_indexed | 2024-04-10T13:20:38Z |
| format | Article |
| id | doaj.art-c1f3ea9f69db4c22b3fbb93780f16c80 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T13:20:38Z |
| publishDate | 2019-04-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-c1f3ea9f69db4c22b3fbb93780f16c802023-02-15T16:12:05ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692019-04-0147317718410.5543/tkda.2018.45213TKDA-45213Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional studyAlireza Amirzadegan0Elnaz Salimi1Ali Hosseinsabet2Department Of Cardiology, Tehran University Of Medical Sciences, Tehran, IranDepartment Of Cardiology, Tehran University Of Medical Sciences, Tehran, IranDepartment Of Cardiology, Tehran University Of Medical Sciences, Tehran, IranObjective: Prolactin is correlated with some conditions that predispose individuals to atherosclerosis. Prolactin receptors have been found in atherosclerotic plaques. However, the correlation between the serum prolactin level and the extension and severity of coronary artery atherosclerosis has yet to be studied. Methods: In total, 414 postmenopausal women candidated for selective coronary angiography with normal serum prolactin levels were enrolled. The patients' lipid profile and levels of serum prolactin, thyroid-stimulating hormone, C-reactive protein, urea, creatinine, and fasting blood sugar were measured. The Gensini score for each patient was calculated. The study population was divided into 3 groups according to the tertile of the serum prolactin level. Results: There was no statistically significant difference in terms of the Gensini score between the 3 groups in the univariate analysis (P = 0.075). The multivariable analysis showed that the serum prolactin level was not an independent determinant of the Gensini score (P = 0.430), whereas age, hypertension, diabetes and dyslipidemia were the independent determinants of the Gensini score. Conclusions: There was no statistically significant correlation between the serum prolactin level and coronary artery atherosclerosis expressed as the Gensini score in our sample of postmenopausal women.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-45213prolactincoronary artery diseasepost menopause |
| spellingShingle | Alireza Amirzadegan Elnaz Salimi Ali Hosseinsabet Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional study Türk Kardiyoloji Derneği Arşivi prolactin coronary artery disease post menopause |
| title | Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional study |
| title_full | Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional study |
| title_fullStr | Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional study |
| title_full_unstemmed | Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional study |
| title_short | Are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women? A cross-sectional study |
| title_sort | are prolactin serum levels and coronary artery atherosclerosis correlated in postmenopausal women a cross sectional study |
| topic | prolactin coronary artery disease post menopause |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-45213 |
| work_keys_str_mv | AT alirezaamirzadegan areprolactinserumlevelsandcoronaryarteryatherosclerosiscorrelatedinpostmenopausalwomenacrosssectionalstudy AT elnazsalimi areprolactinserumlevelsandcoronaryarteryatherosclerosiscorrelatedinpostmenopausalwomenacrosssectionalstudy AT alihosseinsabet areprolactinserumlevelsandcoronaryarteryatherosclerosiscorrelatedinpostmenopausalwomenacrosssectionalstudy |