Industrialization’s eye view on theranostic nanomedicine
The emergence of nanomedicines (NMs) in the healthcare industry will bring about groundbreaking improvements to the current therapeutic and diagnostic scenario. However, only a few NMs have been developed into clinical applications due to a lack of regulatory experience with them. In this article, w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.918715/full |
| _version_ | 1798037605006180352 |
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| author | Maharajan Sivasubramanian Li-Jie Lin Yu-Chao Wang Chung-Shi Yang Leu-Wei Lo |
| author_facet | Maharajan Sivasubramanian Li-Jie Lin Yu-Chao Wang Chung-Shi Yang Leu-Wei Lo |
| author_sort | Maharajan Sivasubramanian |
| collection | DOAJ |
| description | The emergence of nanomedicines (NMs) in the healthcare industry will bring about groundbreaking improvements to the current therapeutic and diagnostic scenario. However, only a few NMs have been developed into clinical applications due to a lack of regulatory experience with them. In this article, we introduce the types of NM that have the potential for clinical translation, including theranostics, multistep NMs, multitherapy NMs, and nanoclusters. We then present the clinical translational challenges associated with NM from the pharmaceutical industry’s perspective, such as NMs’ intrinsic physiochemical properties, safety, scale-up, lack of regulatory experience and standard characterization methods, and cost-effectiveness compared with their traditional counterparts. Overall, NMs face a difficult task to overcome these challenges for their transition from bench to clinical use. |
| first_indexed | 2024-04-11T21:28:49Z |
| format | Article |
| id | doaj.art-c1f4398bb6bd423297c084eb31d26276 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-11T21:28:49Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-c1f4398bb6bd423297c084eb31d262762022-12-22T04:02:16ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-08-011010.3389/fchem.2022.918715918715Industrialization’s eye view on theranostic nanomedicineMaharajan SivasubramanianLi-Jie LinYu-Chao WangChung-Shi YangLeu-Wei LoThe emergence of nanomedicines (NMs) in the healthcare industry will bring about groundbreaking improvements to the current therapeutic and diagnostic scenario. However, only a few NMs have been developed into clinical applications due to a lack of regulatory experience with them. In this article, we introduce the types of NM that have the potential for clinical translation, including theranostics, multistep NMs, multitherapy NMs, and nanoclusters. We then present the clinical translational challenges associated with NM from the pharmaceutical industry’s perspective, such as NMs’ intrinsic physiochemical properties, safety, scale-up, lack of regulatory experience and standard characterization methods, and cost-effectiveness compared with their traditional counterparts. Overall, NMs face a difficult task to overcome these challenges for their transition from bench to clinical use.https://www.frontiersin.org/articles/10.3389/fchem.2022.918715/fulltranslational nanomedicinedrug nanoformulationtheranosticsmultifunctional nanotheranosticsmultistep nanotheranosticsISO and ASTM international |
| spellingShingle | Maharajan Sivasubramanian Li-Jie Lin Yu-Chao Wang Chung-Shi Yang Leu-Wei Lo Industrialization’s eye view on theranostic nanomedicine Frontiers in Chemistry translational nanomedicine drug nanoformulation theranostics multifunctional nanotheranostics multistep nanotheranostics ISO and ASTM international |
| title | Industrialization’s eye view on theranostic nanomedicine |
| title_full | Industrialization’s eye view on theranostic nanomedicine |
| title_fullStr | Industrialization’s eye view on theranostic nanomedicine |
| title_full_unstemmed | Industrialization’s eye view on theranostic nanomedicine |
| title_short | Industrialization’s eye view on theranostic nanomedicine |
| title_sort | industrialization s eye view on theranostic nanomedicine |
| topic | translational nanomedicine drug nanoformulation theranostics multifunctional nanotheranostics multistep nanotheranostics ISO and ASTM international |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.918715/full |
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