Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex
Abstract Recent theories of cortical organisation suggest features of function emerge from the spatial arrangement of brain regions. For example, association cortex is located furthest from systems involved in action and perception. Association cortex is also ‘interdigitated’ with adjacent regions h...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41334-2 |
| _version_ | 1797558824219967488 |
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| author | Robert Leech Reinder Vos De Wael František Váša Ting Xu R. Austin Benn Robert Scholz Rodrigo M. Braga Michael P. Milham Jessica Royer Boris C. Bernhardt Emily J. H. Jones Elizabeth Jefferies Daniel S. Margulies Jonathan Smallwood |
| author_facet | Robert Leech Reinder Vos De Wael František Váša Ting Xu R. Austin Benn Robert Scholz Rodrigo M. Braga Michael P. Milham Jessica Royer Boris C. Bernhardt Emily J. H. Jones Elizabeth Jefferies Daniel S. Margulies Jonathan Smallwood |
| author_sort | Robert Leech |
| collection | DOAJ |
| description | Abstract Recent theories of cortical organisation suggest features of function emerge from the spatial arrangement of brain regions. For example, association cortex is located furthest from systems involved in action and perception. Association cortex is also ‘interdigitated’ with adjacent regions having different patterns of functional connectivity. It is assumed that topographic properties, such as distance between regions, constrains their functions, however, we lack a formal description of how this occurs. Here we use variograms, a quantification of spatial autocorrelation, to profile how function changes with the distance between cortical regions. We find function changes with distance more gradually within sensory-motor cortex than association cortex. Importantly, systems within the same type of cortex (e.g., fronto-parietal and default mode networks) have similar profiles. Primary and association cortex, therefore, are differentiated by how function changes over space, emphasising the value of topographical features of a region when estimating its contribution to cognition and behaviour. |
| first_indexed | 2024-03-10T17:35:50Z |
| format | Article |
| id | doaj.art-c1f4bd43b7084dfeb9fd0dcbc2de28ef |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:35:50Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c1f4bd43b7084dfeb9fd0dcbc2de28ef2023-11-20T09:51:19ZengNature PortfolioNature Communications2041-17232023-09-0114111110.1038/s41467-023-41334-2Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortexRobert Leech0Reinder Vos De Wael1František Váša2Ting Xu3R. Austin Benn4Robert Scholz5Rodrigo M. Braga6Michael P. Milham7Jessica Royer8Boris C. Bernhardt9Emily J. H. Jones10Elizabeth Jefferies11Daniel S. Margulies12Jonathan Smallwood13Centre for Neuroimaging Science, King’s College LondonMcConnell Brain Imaging Centre, McGill UniversityCentre for Neuroimaging Science, King’s College LondonCenter for the Developing Brain, Child Mind InstituteIntegrative Neuroscience and Cognition Center (UMR 8002), Centre National de la Recherche Scientifique (CNRS) and Université de ParisMax Planck School of CognitionNeurology, Interdepartmental Neuroscience Program, Northwestern UniversityCenter for the Developing Brain, Child Mind InstituteMcConnell Brain Imaging Centre, McGill UniversityMcConnell Brain Imaging Centre, McGill UniversityCentre for Brain and Cognitive Development, Birkbeck College, University of LondonDepartment of Psychology, University of YorkIntegrative Neuroscience and Cognition Center (UMR 8002), Centre National de la Recherche Scientifique (CNRS) and Université de ParisDepartment of Psychology, Queens UniversityAbstract Recent theories of cortical organisation suggest features of function emerge from the spatial arrangement of brain regions. For example, association cortex is located furthest from systems involved in action and perception. Association cortex is also ‘interdigitated’ with adjacent regions having different patterns of functional connectivity. It is assumed that topographic properties, such as distance between regions, constrains their functions, however, we lack a formal description of how this occurs. Here we use variograms, a quantification of spatial autocorrelation, to profile how function changes with the distance between cortical regions. We find function changes with distance more gradually within sensory-motor cortex than association cortex. Importantly, systems within the same type of cortex (e.g., fronto-parietal and default mode networks) have similar profiles. Primary and association cortex, therefore, are differentiated by how function changes over space, emphasising the value of topographical features of a region when estimating its contribution to cognition and behaviour.https://doi.org/10.1038/s41467-023-41334-2 |
| spellingShingle | Robert Leech Reinder Vos De Wael František Váša Ting Xu R. Austin Benn Robert Scholz Rodrigo M. Braga Michael P. Milham Jessica Royer Boris C. Bernhardt Emily J. H. Jones Elizabeth Jefferies Daniel S. Margulies Jonathan Smallwood Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex Nature Communications |
| title | Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex |
| title_full | Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex |
| title_fullStr | Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex |
| title_full_unstemmed | Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex |
| title_short | Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex |
| title_sort | variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex |
| url | https://doi.org/10.1038/s41467-023-41334-2 |
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