The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer
Introduction: Tumor microenvironment plays a significant role in tumor progression. Tumor stroma is one of the strongest modifiers of tumor cell response, cancer behavior, and cancer progression. This study aimed to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression and tum...
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| Format: | Article |
| Language: | English |
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University of Sarajevo
2021-01-01
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| Series: | Journal of Health Sciences |
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| Online Access: | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/1121 |
| _version_ | 1818877049373196288 |
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| author | Nina Čamdžić Suada Kuskunović-Vlahovljak Svjetlana Radović Mirsad Dorić Mirsad Babić Edina Lazović Salčin Amir Spahić |
| author_facet | Nina Čamdžić Suada Kuskunović-Vlahovljak Svjetlana Radović Mirsad Dorić Mirsad Babić Edina Lazović Salčin Amir Spahić |
| author_sort | Nina Čamdžić |
| collection | DOAJ |
| description | Introduction: Tumor microenvironment plays a significant role in tumor progression. Tumor stroma is one of the strongest modifiers of tumor cell response, cancer behavior, and cancer progression. This study aimed to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression and tumor-stroma ratio (TSR) with standard clinicopathological parameters in different molecular subtypes of breast cancer.
Methods: Ninety biopsy samples of primary breast cancer diagnosed at the Department of Pathology, School of Medicine, Sarajevo, were selected for this study. The molecular subtype was determined based on the immunohistochemical expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67. Stromal and tumoral MMP-9 immunohistochemical expression and the TSR were determined for each tumor.
Results: Tumoral MMP-9 expression correlated positively with the presence of lymphovascular invasion (p= 0.016). TSR showed significant association and correlation with tumor grade (G) (p= 0.031; p= 0.049) and tumor size (pT) (p = 0.049;p= 0.021, respectively). Stromal MMP-9 expression correlated with histologic type, histologic grade of tumor, and lymphocytic inflammatory infiltrate (p= 0.021;p= 0.047, p= 0.038, respectively). A higher percentage of stromal MMP-9 expression correlated with the strongest lymphocytic response (p = 0.007). Significant correlation was observed between molecular subtypes and histologic grade of the tumor (p= 0.032).
Conclusion: Our results, to some extent, confirm the significance of the tumor microenvironment in breast cancer, especially when it is about stromal MMP-9 expression. Although we observed significant association, without linear correlation, we found no significant correlation between molecular subtypes of breast cancer and MMP-9 expression. |
| first_indexed | 2024-12-19T13:52:06Z |
| format | Article |
| id | doaj.art-c1f64036f93f42a6ba984e0f96447d25 |
| institution | Directory Open Access Journal |
| issn | 2232-7576 1986-8049 |
| language | English |
| last_indexed | 2024-12-19T13:52:06Z |
| publishDate | 2021-01-01 |
| publisher | University of Sarajevo |
| record_format | Article |
| series | Journal of Health Sciences |
| spelling | doaj.art-c1f64036f93f42a6ba984e0f96447d252022-12-21T20:18:41ZengUniversity of SarajevoJournal of Health Sciences2232-75761986-80492021-01-0110.17532/jhsci.2021.1121The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancerNina Čamdžić0Suada Kuskunović-Vlahovljak1Svjetlana Radović2Mirsad Dorić3Mirsad Babić4Edina Lazović Salčin5Amir Spahić6Department of Pathology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Pathology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Pathology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Pathology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Pathology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Pathology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Pathology, Cantonal Hospital Travnik, Travnik, Bosnia and HerzegovinaIntroduction: Tumor microenvironment plays a significant role in tumor progression. Tumor stroma is one of the strongest modifiers of tumor cell response, cancer behavior, and cancer progression. This study aimed to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression and tumor-stroma ratio (TSR) with standard clinicopathological parameters in different molecular subtypes of breast cancer. Methods: Ninety biopsy samples of primary breast cancer diagnosed at the Department of Pathology, School of Medicine, Sarajevo, were selected for this study. The molecular subtype was determined based on the immunohistochemical expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67. Stromal and tumoral MMP-9 immunohistochemical expression and the TSR were determined for each tumor. Results: Tumoral MMP-9 expression correlated positively with the presence of lymphovascular invasion (p= 0.016). TSR showed significant association and correlation with tumor grade (G) (p= 0.031; p= 0.049) and tumor size (pT) (p = 0.049;p= 0.021, respectively). Stromal MMP-9 expression correlated with histologic type, histologic grade of tumor, and lymphocytic inflammatory infiltrate (p= 0.021;p= 0.047, p= 0.038, respectively). A higher percentage of stromal MMP-9 expression correlated with the strongest lymphocytic response (p = 0.007). Significant correlation was observed between molecular subtypes and histologic grade of the tumor (p= 0.032). Conclusion: Our results, to some extent, confirm the significance of the tumor microenvironment in breast cancer, especially when it is about stromal MMP-9 expression. Although we observed significant association, without linear correlation, we found no significant correlation between molecular subtypes of breast cancer and MMP-9 expression.https://www.jhsci.ba/ojs/index.php/jhsci/article/view/1121Breast cancermolecular subtypestumor microenvironmentmatrix metalloproteinase-9tumor-stroma ratio |
| spellingShingle | Nina Čamdžić Suada Kuskunović-Vlahovljak Svjetlana Radović Mirsad Dorić Mirsad Babić Edina Lazović Salčin Amir Spahić The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer Journal of Health Sciences Breast cancer molecular subtypes tumor microenvironment matrix metalloproteinase-9 tumor-stroma ratio |
| title | The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer |
| title_full | The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer |
| title_fullStr | The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer |
| title_full_unstemmed | The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer |
| title_short | The relationship of tumor microenvironment and clinico-pathological parameters in different molecular subtypes of breast cancer |
| title_sort | relationship of tumor microenvironment and clinico pathological parameters in different molecular subtypes of breast cancer |
| topic | Breast cancer molecular subtypes tumor microenvironment matrix metalloproteinase-9 tumor-stroma ratio |
| url | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/1121 |
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