Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [<sup>18</sup>F]AlF-Affibody Conjugates

Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [<sup>18</sup>F]AlF-Affibody Conjugates

Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide–thiol reaction (Michael addition). When maleimide-functionalized chelators are used and the resulting bioconjugates are subsequently radiolabeled, instability has been observed both durin...

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Bibliographic Details
Main Authors: Chiara Da Pieve, Ata Makarem, Stephen Turnock, Justyna Maczynska, Graham Smith, Gabriela Kramer-Marek
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
[<sup>18</sup>F]AlF
NOTA
NODAGA
PODS
thiol-reactive
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Online Access:https://www.mdpi.com/1420-3049/25/7/1562

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