Superoxide Dismutases in Eukaryotic Microorganisms: Four Case Studies
Various components in the cell are responsible for maintaining physiological levels of reactive oxygen species (ROS). Several different enzymes exist that can convert or degrade ROS; among them are the superoxide dismutases (SODs). If left unchecked, ROS can cause damage that leads to pathology, can...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/2/188 |
| _version_ | 1797483354070712320 |
|---|---|
| author | Alvaro de Obeso Fernandez del Valle Christian Quintus Scheckhuber |
| author_facet | Alvaro de Obeso Fernandez del Valle Christian Quintus Scheckhuber |
| author_sort | Alvaro de Obeso Fernandez del Valle |
| collection | DOAJ |
| description | Various components in the cell are responsible for maintaining physiological levels of reactive oxygen species (ROS). Several different enzymes exist that can convert or degrade ROS; among them are the superoxide dismutases (SODs). If left unchecked, ROS can cause damage that leads to pathology, can contribute to aging, and may, ultimately, cause death. SODs are responsible for converting superoxide anions to hydrogen peroxide by dismutation. Here we review the role of different SODs on the development and pathogenicity of various eukaryotic microorganisms relevant to human health. These include the fungal aging model, <i>Podospora anserina</i>; various members of the genus <i>Aspergillus</i> that can potentially cause aspergillosis; the agents of diseases such as Chagas and sleeping disease, <i>Trypanosoma</i> <i>cruzi</i> and <i>Trypanosoma</i> <i>brucei</i>, respectively; and, finally, pathogenic amoebae, such as <i>Acanthamoeba</i> spp. In these organisms, SODs fulfill essential and often regulatory functions that come into play during processes such as the development, host infection, propagation, and control of gene expression. We explore the contribution of SODs and their related factors in these microorganisms, which have an established role in health and disease. |
| first_indexed | 2024-03-09T22:45:48Z |
| format | Article |
| id | doaj.art-c1f94a791cb84b029f9ecae0d8e4a68e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:45:48Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c1f94a791cb84b029f9ecae0d8e4a68e2023-11-23T18:29:45ZengMDPI AGAntioxidants2076-39212022-01-0111218810.3390/antiox11020188Superoxide Dismutases in Eukaryotic Microorganisms: Four Case StudiesAlvaro de Obeso Fernandez del Valle0Christian Quintus Scheckhuber1Departamento de Bioingeniería, Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey 64849, MexicoDepartamento de Bioingeniería, Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey 64849, MexicoVarious components in the cell are responsible for maintaining physiological levels of reactive oxygen species (ROS). Several different enzymes exist that can convert or degrade ROS; among them are the superoxide dismutases (SODs). If left unchecked, ROS can cause damage that leads to pathology, can contribute to aging, and may, ultimately, cause death. SODs are responsible for converting superoxide anions to hydrogen peroxide by dismutation. Here we review the role of different SODs on the development and pathogenicity of various eukaryotic microorganisms relevant to human health. These include the fungal aging model, <i>Podospora anserina</i>; various members of the genus <i>Aspergillus</i> that can potentially cause aspergillosis; the agents of diseases such as Chagas and sleeping disease, <i>Trypanosoma</i> <i>cruzi</i> and <i>Trypanosoma</i> <i>brucei</i>, respectively; and, finally, pathogenic amoebae, such as <i>Acanthamoeba</i> spp. In these organisms, SODs fulfill essential and often regulatory functions that come into play during processes such as the development, host infection, propagation, and control of gene expression. We explore the contribution of SODs and their related factors in these microorganisms, which have an established role in health and disease.https://www.mdpi.com/2076-3921/11/2/188<i>Acanthamoeba</i><i>Aspergillus</i>developmentpathogenicity<i>Podospora</i> <i>anserina</i>reactive oxygen species |
| spellingShingle | Alvaro de Obeso Fernandez del Valle Christian Quintus Scheckhuber Superoxide Dismutases in Eukaryotic Microorganisms: Four Case Studies Antioxidants <i>Acanthamoeba</i> <i>Aspergillus</i> development pathogenicity <i>Podospora</i> <i>anserina</i> reactive oxygen species |
| title | Superoxide Dismutases in Eukaryotic Microorganisms: Four Case Studies |
| title_full | Superoxide Dismutases in Eukaryotic Microorganisms: Four Case Studies |
| title_fullStr | Superoxide Dismutases in Eukaryotic Microorganisms: Four Case Studies |
| title_full_unstemmed | Superoxide Dismutases in Eukaryotic Microorganisms: Four Case Studies |
| title_short | Superoxide Dismutases in Eukaryotic Microorganisms: Four Case Studies |
| title_sort | superoxide dismutases in eukaryotic microorganisms four case studies |
| topic | <i>Acanthamoeba</i> <i>Aspergillus</i> development pathogenicity <i>Podospora</i> <i>anserina</i> reactive oxygen species |
| url | https://www.mdpi.com/2076-3921/11/2/188 |
| work_keys_str_mv | AT alvarodeobesofernandezdelvalle superoxidedismutasesineukaryoticmicroorganismsfourcasestudies AT christianquintusscheckhuber superoxidedismutasesineukaryoticmicroorganismsfourcasestudies |