Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved]
Primary cytomegalovirus (CMV) infection leads to strong innate and adaptive immune responses against the virus, which prevents serious disease. However, CMV infection can cause serious morbidity and mortality in individuals who are immunocompromised. The adaptive immune response to CMV is characteri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-09-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-1554/v1 |
| _version_ | 1818872886657548288 |
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| author | Iris N. Pardieck Guillaume Beyrend Anke Redeker Ramon Arens |
| author_facet | Iris N. Pardieck Guillaume Beyrend Anke Redeker Ramon Arens |
| author_sort | Iris N. Pardieck |
| collection | DOAJ |
| description | Primary cytomegalovirus (CMV) infection leads to strong innate and adaptive immune responses against the virus, which prevents serious disease. However, CMV infection can cause serious morbidity and mortality in individuals who are immunocompromised. The adaptive immune response to CMV is characterized by large populations of effector-memory (EM) T cells that are maintained lifelong, a process termed memory inflation. Recent findings indicate that infection with CMV leads to continuous differentiation of CMV-specific EM-like T cells and that high-dose infection accelerates this progression. Whether measures that counteract CMV infection, such as anti-viral drugs, targeting of latently infected cells, adoptive transfer of CMV-specific T cells, and vaccination strategies, are able to impact the progressive differentiation of CMV-specific EM-like cells is discussed. |
| first_indexed | 2024-12-19T12:45:56Z |
| format | Article |
| id | doaj.art-c1fb6766a41445c2ace398df37ceda3c |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-19T12:45:56Z |
| publishDate | 2018-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-c1fb6766a41445c2ace398df37ceda3c2022-12-21T20:20:46ZengF1000 Research LtdF1000Research2046-14022018-09-01710.12688/f1000research.15753.117195Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved]Iris N. Pardieck0Guillaume Beyrend1Anke Redeker2Ramon Arens3Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The NetherlandsDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The NetherlandsDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The NetherlandsDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The NetherlandsPrimary cytomegalovirus (CMV) infection leads to strong innate and adaptive immune responses against the virus, which prevents serious disease. However, CMV infection can cause serious morbidity and mortality in individuals who are immunocompromised. The adaptive immune response to CMV is characterized by large populations of effector-memory (EM) T cells that are maintained lifelong, a process termed memory inflation. Recent findings indicate that infection with CMV leads to continuous differentiation of CMV-specific EM-like T cells and that high-dose infection accelerates this progression. Whether measures that counteract CMV infection, such as anti-viral drugs, targeting of latently infected cells, adoptive transfer of CMV-specific T cells, and vaccination strategies, are able to impact the progressive differentiation of CMV-specific EM-like cells is discussed.https://f1000research.com/articles/7-1554/v1 |
| spellingShingle | Iris N. Pardieck Guillaume Beyrend Anke Redeker Ramon Arens Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved] F1000Research |
| title | Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved] |
| title_full | Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved] |
| title_fullStr | Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved] |
| title_full_unstemmed | Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved] |
| title_short | Cytomegalovirus infection and progressive differentiation of effector-memory T cells [version 1; referees: 3 approved] |
| title_sort | cytomegalovirus infection and progressive differentiation of effector memory t cells version 1 referees 3 approved |
| url | https://f1000research.com/articles/7-1554/v1 |
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