Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices
Photosensitizers (PSs) are known as powerful antibacterial agents that are activated by direct exposure to visible light. PSs can be noncovalently entrapped into the silica gel network for their controlled release into a contaminated area. The immobilization of PS-containing gel matrices on a polyme...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3716 |
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| author | Yanna Gurianov Michael Meistelman Yael Albo Marina Nisnevitch Faina Nakonechny |
| author_facet | Yanna Gurianov Michael Meistelman Yael Albo Marina Nisnevitch Faina Nakonechny |
| author_sort | Yanna Gurianov |
| collection | DOAJ |
| description | Photosensitizers (PSs) are known as powerful antibacterial agents that are activated by direct exposure to visible light. PSs can be noncovalently entrapped into the silica gel network for their controlled release into a contaminated area. The immobilization of PS-containing gel matrices on a polymer support expands their possible applications, such as antibacterial surfaces and coatings, which can be used for the disinfection of liquids. In the current study, we report the use of Rose Bengal (RB) incorporated into organically modified silica matrices (RB@ORMOSIL matrices) by the sol-gel technique. The RB matrices exhibit high activity against Gram-positive and Gram-negative bacteria under illumination by white light. The amount and timing of solidifier addition to the matrix affected the interaction of the latter with the RB, which in turn could affect the antibacterial activity of RB. The most active specimen against both Gram-positive and Gram-negative bacterial cells was the RB6@ORMOSIL matrix immobilized on a linear low-density polyethylene surface, which was prepared by an easy, cost-effective, and simple thermal adhesion method. This specimen, RB6@OR@LLDPE, showed the low release of RB in an aqueous environment, and exhibited high long-term antibacterial activity in at least 14 rounds of recycled use against <i>S. aureus</i> and in 11 rounds against <i>E. coli</i>. |
| first_indexed | 2024-03-09T11:46:50Z |
| format | Article |
| id | doaj.art-c1fc6a0e9c6c484f8ee7bf44b06271b9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:46:50Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c1fc6a0e9c6c484f8ee7bf44b06271b92023-11-30T23:21:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237371610.3390/ijms23073716Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica MatricesYanna Gurianov0Michael Meistelman1Yael Albo2Marina Nisnevitch3Faina Nakonechny4Department of Chemical Engineering, Ariel University, Kyriat-ha-Mada, Ariel 4070000, IsraelDepartment of Chemical Engineering, Ariel University, Kyriat-ha-Mada, Ariel 4070000, IsraelDepartment of Chemical Engineering, Ariel University, Kyriat-ha-Mada, Ariel 4070000, IsraelDepartment of Chemical Engineering, Ariel University, Kyriat-ha-Mada, Ariel 4070000, IsraelDepartment of Chemical Engineering, Ariel University, Kyriat-ha-Mada, Ariel 4070000, IsraelPhotosensitizers (PSs) are known as powerful antibacterial agents that are activated by direct exposure to visible light. PSs can be noncovalently entrapped into the silica gel network for their controlled release into a contaminated area. The immobilization of PS-containing gel matrices on a polymer support expands their possible applications, such as antibacterial surfaces and coatings, which can be used for the disinfection of liquids. In the current study, we report the use of Rose Bengal (RB) incorporated into organically modified silica matrices (RB@ORMOSIL matrices) by the sol-gel technique. The RB matrices exhibit high activity against Gram-positive and Gram-negative bacteria under illumination by white light. The amount and timing of solidifier addition to the matrix affected the interaction of the latter with the RB, which in turn could affect the antibacterial activity of RB. The most active specimen against both Gram-positive and Gram-negative bacterial cells was the RB6@ORMOSIL matrix immobilized on a linear low-density polyethylene surface, which was prepared by an easy, cost-effective, and simple thermal adhesion method. This specimen, RB6@OR@LLDPE, showed the low release of RB in an aqueous environment, and exhibited high long-term antibacterial activity in at least 14 rounds of recycled use against <i>S. aureus</i> and in 11 rounds against <i>E. coli</i>.https://www.mdpi.com/1422-0067/23/7/3716Rose Bengalphotosensitizerssol-gelmodified silicaantibacterial surfaces |
| spellingShingle | Yanna Gurianov Michael Meistelman Yael Albo Marina Nisnevitch Faina Nakonechny Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices International Journal of Molecular Sciences Rose Bengal photosensitizers sol-gel modified silica antibacterial surfaces |
| title | Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices |
| title_full | Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices |
| title_fullStr | Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices |
| title_full_unstemmed | Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices |
| title_short | Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices |
| title_sort | antibacterial activity of rose bengal entrapped in organically modified silica matrices |
| topic | Rose Bengal photosensitizers sol-gel modified silica antibacterial surfaces |
| url | https://www.mdpi.com/1422-0067/23/7/3716 |
| work_keys_str_mv | AT yannagurianov antibacterialactivityofrosebengalentrappedinorganicallymodifiedsilicamatrices AT michaelmeistelman antibacterialactivityofrosebengalentrappedinorganicallymodifiedsilicamatrices AT yaelalbo antibacterialactivityofrosebengalentrappedinorganicallymodifiedsilicamatrices AT marinanisnevitch antibacterialactivityofrosebengalentrappedinorganicallymodifiedsilicamatrices AT fainanakonechny antibacterialactivityofrosebengalentrappedinorganicallymodifiedsilicamatrices |