Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection
ObjectiveThe objective of this study is to investigate the association between toll-like receptor (TLR) 3/7 gene polymorphisms and the infection by hepatitis C virus (HCV).MethodsPubMed, Embase, Web of Science, Scopus, CNKI, Wanfang Data, and SinoMed were searched to identify studies focusing on the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1254805/full |
| _version_ | 1797523016005976064 |
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| author | Yuxuan Du Shumin Li Xinyu Wang Jialu Liu Yan Gao Weimiao Lv Ping Liu Haiyan Huang Junwen Luan Leiliang Zhang |
| author_facet | Yuxuan Du Shumin Li Xinyu Wang Jialu Liu Yan Gao Weimiao Lv Ping Liu Haiyan Huang Junwen Luan Leiliang Zhang |
| author_sort | Yuxuan Du |
| collection | DOAJ |
| description | ObjectiveThe objective of this study is to investigate the association between toll-like receptor (TLR) 3/7 gene polymorphisms and the infection by hepatitis C virus (HCV).MethodsPubMed, Embase, Web of Science, Scopus, CNKI, Wanfang Data, and SinoMed were searched to identify studies focusing on the association between the TLR3 rs3775290 or the TLR7 rs179008 single nucleotide polymorphisms (SNPs) and the HCV infection. All the related articles were collected from the inception of each database to 15 January 2023. Our meta-analysis was conducted using the allelic model, the dominant model, and the recessive model. Outcomes were presented by odds ratio (ORs) and 95% confidence interval (95%CI). The heterogeneity across studies was assessed by the I2 test. A subgroup analysis was performed to explore the source of heterogeneity. Funnel plots were drawn to assess the risk of publication bias. Review Manager 5.4 was used for statistical analysis.ResultsTen articles were finally included, among which six studies were analyzed for rs3775290 and five studies were analyzed for rs179008. Studies relating to rs3775290 included 801 patients and 1,045 controls, whereas studies relating to rs179008 included 924 patients and 784 controls. The results of the meta-analysis showed that there is no significant association between rs3775290 gene polymorphism and HCV infection (T vs. C: OR = 1.12, 95%CI 0.97–1.30; TT+CT vs. CC: OR = 1.20, 95%CI 0.73–1.96; TT vs. CT+CC: OR = 1.13, 95%CI 0.68–1.89). The recessive model showed that rs179008-T allele homozygotes had an 89% increased risk of infection by HCV compared with rs179008-A allele carriers (TT vs. AT+AA: OR = 1.89, 95%CI 1.13–3.16). The results of the subgroup analysis demonstrated that the characteristics of the control population may serve as an important source of heterogeneity. In the African populations, individuals with homozygous rs179008-T alleles had a higher risk of infection by HCV than rs179008-A allele carriers (OR = 2.14, 95%CI 1.18–3.87). We did not find that this difference existed in the European populations (OR = 1.24, 95%CI 0.43–3.56).ConclusionThere is no significant association between rs3775290 single nucleotide polymorphism and the infection by HCV. Individuals with homozygous rs179008-T alleles have a higher risk of an infection by HCV than rs179008-A allele carriers, which is statistically significant in the African populations. |
| first_indexed | 2024-03-10T08:36:28Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-10T08:36:28Z |
| publishDate | 2023-10-01 |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-c1ff06fb3d25483faab3acaca6dc5ace2023-11-22T08:37:55ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-10-011410.3389/fmicb.2023.12548051254805Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infectionYuxuan Du0Shumin Li1Xinyu Wang2Jialu Liu3Yan Gao4Weimiao Lv5Ping Liu6Haiyan Huang7Junwen Luan8Leiliang Zhang9School of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Clinical and Basic Medical Sciences & Institute of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaObjectiveThe objective of this study is to investigate the association between toll-like receptor (TLR) 3/7 gene polymorphisms and the infection by hepatitis C virus (HCV).MethodsPubMed, Embase, Web of Science, Scopus, CNKI, Wanfang Data, and SinoMed were searched to identify studies focusing on the association between the TLR3 rs3775290 or the TLR7 rs179008 single nucleotide polymorphisms (SNPs) and the HCV infection. All the related articles were collected from the inception of each database to 15 January 2023. Our meta-analysis was conducted using the allelic model, the dominant model, and the recessive model. Outcomes were presented by odds ratio (ORs) and 95% confidence interval (95%CI). The heterogeneity across studies was assessed by the I2 test. A subgroup analysis was performed to explore the source of heterogeneity. Funnel plots were drawn to assess the risk of publication bias. Review Manager 5.4 was used for statistical analysis.ResultsTen articles were finally included, among which six studies were analyzed for rs3775290 and five studies were analyzed for rs179008. Studies relating to rs3775290 included 801 patients and 1,045 controls, whereas studies relating to rs179008 included 924 patients and 784 controls. The results of the meta-analysis showed that there is no significant association between rs3775290 gene polymorphism and HCV infection (T vs. C: OR = 1.12, 95%CI 0.97–1.30; TT+CT vs. CC: OR = 1.20, 95%CI 0.73–1.96; TT vs. CT+CC: OR = 1.13, 95%CI 0.68–1.89). The recessive model showed that rs179008-T allele homozygotes had an 89% increased risk of infection by HCV compared with rs179008-A allele carriers (TT vs. AT+AA: OR = 1.89, 95%CI 1.13–3.16). The results of the subgroup analysis demonstrated that the characteristics of the control population may serve as an important source of heterogeneity. In the African populations, individuals with homozygous rs179008-T alleles had a higher risk of infection by HCV than rs179008-A allele carriers (OR = 2.14, 95%CI 1.18–3.87). We did not find that this difference existed in the European populations (OR = 1.24, 95%CI 0.43–3.56).ConclusionThere is no significant association between rs3775290 single nucleotide polymorphism and the infection by HCV. Individuals with homozygous rs179008-T alleles have a higher risk of an infection by HCV than rs179008-A allele carriers, which is statistically significant in the African populations.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1254805/fullhepatitis C (HCV)virustoll-like receptor (TLR)single nucleotide polymorphisms (SNP)meta-analysis |
| spellingShingle | Yuxuan Du Shumin Li Xinyu Wang Jialu Liu Yan Gao Weimiao Lv Ping Liu Haiyan Huang Junwen Luan Leiliang Zhang Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection Frontiers in Microbiology hepatitis C (HCV) virus toll-like receptor (TLR) single nucleotide polymorphisms (SNP) meta-analysis |
| title | Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection |
| title_full | Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection |
| title_fullStr | Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection |
| title_full_unstemmed | Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection |
| title_short | Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection |
| title_sort | meta analysis of the association between toll like receptor gene polymorphisms and hepatitis c virus infection |
| topic | hepatitis C (HCV) virus toll-like receptor (TLR) single nucleotide polymorphisms (SNP) meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1254805/full |
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