Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder
Bipolar disorder (BD) is a severe manic-depressive illness. Patients with BD have been shown to have gray matter (GM) deficits in prefrontal, frontal, parietal, and temporal regions; however, the relationship between structural effects and clinical profiles has proved elusive when considered on a re...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158219303390 |
| _version_ | 1818543969769881600 |
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| author | Wenhao Jiang Ole A. Andreassen Ingrid Agartz Trine V. Lagerberg Lars T. Westlye Vince D. Calhoun Jessica A. Turner |
| author_facet | Wenhao Jiang Ole A. Andreassen Ingrid Agartz Trine V. Lagerberg Lars T. Westlye Vince D. Calhoun Jessica A. Turner |
| author_sort | Wenhao Jiang |
| collection | DOAJ |
| description | Bipolar disorder (BD) is a severe manic-depressive illness. Patients with BD have been shown to have gray matter (GM) deficits in prefrontal, frontal, parietal, and temporal regions; however, the relationship between structural effects and clinical profiles has proved elusive when considered on a region by region or voxel by voxel basis. In this study, we applied parallel independent component analysis (pICA) to structural neuroimaging measures and the positive and negative syndrome scale (PANSS) in 110 patients (mean age 34.9 ± 11.65) with bipolar disorder, to examine networks of brain regions that relate to symptom profiles. The pICA revealed two distinct symptom profiles and associated GM concentration alteration circuits. The first PANSS pICA profile mainly involved anxiety, depression and guilty feelings, reflecting mood symptoms. Reduced GM concentration in right temporal regions predicted worse mood symptoms in this profile. The second PANSS pICA profile generally covered blunted affect, emotional withdrawal, passive/apathetic social withdrawal, depression and active social avoidance, exhibiting a withdrawal or apathy dominating component. Lower GM concentration in bilateral parietal and frontal regions showed worse symptom severity in this profile. In summary, a pICA decomposition suggested BD patients showed distinct mood and apathy profiles differing from the original PANSS subscales, relating to distinct brain structural networks. |
| first_indexed | 2024-12-11T22:42:21Z |
| format | Article |
| id | doaj.art-c1ff98a824ae40ef9e3e606108b0fe44 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-11T22:42:21Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-c1ff98a824ae40ef9e3e606108b0fe442022-12-22T00:47:45ZengElsevierNeuroImage: Clinical2213-15822020-01-0126Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorderWenhao Jiang0Ole A. Andreassen1Ingrid Agartz2Trine V. Lagerberg3Lars T. Westlye4Vince D. Calhoun5Jessica A. Turner6Department of Psychology, Georgia State University, USANORMENT, Institute of Clinical Medicine, University of Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, NorwayDepartment of Psychology, University of Oslo, Oslo, Norway; Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, SwedenNORMENT, Institute of Clinical Medicine, University of Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, NorwayNORMENT, Institute of Clinical Medicine, University of Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, NorwayDepartment of Psychology, Georgia State University, USA; Department of Electrical and Computer Engineering, The University of New Mexico, USA; The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, USA; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USADepartment of Psychology, Georgia State University, USA; Corresponding author at: Psychology and Neuroscience, Georgia State University, Atlanta, GA, USA.Bipolar disorder (BD) is a severe manic-depressive illness. Patients with BD have been shown to have gray matter (GM) deficits in prefrontal, frontal, parietal, and temporal regions; however, the relationship between structural effects and clinical profiles has proved elusive when considered on a region by region or voxel by voxel basis. In this study, we applied parallel independent component analysis (pICA) to structural neuroimaging measures and the positive and negative syndrome scale (PANSS) in 110 patients (mean age 34.9 ± 11.65) with bipolar disorder, to examine networks of brain regions that relate to symptom profiles. The pICA revealed two distinct symptom profiles and associated GM concentration alteration circuits. The first PANSS pICA profile mainly involved anxiety, depression and guilty feelings, reflecting mood symptoms. Reduced GM concentration in right temporal regions predicted worse mood symptoms in this profile. The second PANSS pICA profile generally covered blunted affect, emotional withdrawal, passive/apathetic social withdrawal, depression and active social avoidance, exhibiting a withdrawal or apathy dominating component. Lower GM concentration in bilateral parietal and frontal regions showed worse symptom severity in this profile. In summary, a pICA decomposition suggested BD patients showed distinct mood and apathy profiles differing from the original PANSS subscales, relating to distinct brain structural networks.http://www.sciencedirect.com/science/article/pii/S2213158219303390 |
| spellingShingle | Wenhao Jiang Ole A. Andreassen Ingrid Agartz Trine V. Lagerberg Lars T. Westlye Vince D. Calhoun Jessica A. Turner Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder NeuroImage: Clinical |
| title | Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder |
| title_full | Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder |
| title_fullStr | Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder |
| title_full_unstemmed | Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder |
| title_short | Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder |
| title_sort | distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder |
| url | http://www.sciencedirect.com/science/article/pii/S2213158219303390 |
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