Interorgan communication with the liver: novel mechanisms and therapeutic targets
The liver is a multifunctional organ that plays crucial roles in numerous physiological processes, such as production of bile and proteins for blood plasma, regulation of blood levels of amino acids, processing of hemoglobin, clearance of metabolic waste, maintenance of glucose, etc. Therefore, the...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1314123/full |
| _version_ | 1827586559658950656 |
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| author | Jiulu Zhao Jiulu Zhao Xi Zhang Xi Zhang Yuan Li Yuan Li Jizhang Yu Jizhang Yu Zhang Chen Zhang Chen Yuqing Niu Yuqing Niu Shuan Ran Shuan Ran Song Wang Song Wang Weicong Ye Weicong Ye Zilong Luo Zilong Luo Xiaohan Li Xiaohan Li Yanglin Hao Yanglin Hao Junjie Zong Junjie Zong Chengkun Xia Jiahong Xia Jiahong Xia Jiahong Xia Jie Wu Jie Wu Jie Wu |
| author_facet | Jiulu Zhao Jiulu Zhao Xi Zhang Xi Zhang Yuan Li Yuan Li Jizhang Yu Jizhang Yu Zhang Chen Zhang Chen Yuqing Niu Yuqing Niu Shuan Ran Shuan Ran Song Wang Song Wang Weicong Ye Weicong Ye Zilong Luo Zilong Luo Xiaohan Li Xiaohan Li Yanglin Hao Yanglin Hao Junjie Zong Junjie Zong Chengkun Xia Jiahong Xia Jiahong Xia Jiahong Xia Jie Wu Jie Wu Jie Wu |
| author_sort | Jiulu Zhao |
| collection | DOAJ |
| description | The liver is a multifunctional organ that plays crucial roles in numerous physiological processes, such as production of bile and proteins for blood plasma, regulation of blood levels of amino acids, processing of hemoglobin, clearance of metabolic waste, maintenance of glucose, etc. Therefore, the liver is essential for the homeostasis of organisms. With the development of research on the liver, there is growing concern about its effect on immune cells of innate and adaptive immunity. For example, the liver regulates the proliferation, differentiation, and effector functions of immune cells through various secreted proteins (also known as “hepatokines”). As a result, the liver is identified as an important regulator of the immune system. Furthermore, many diseases resulting from immune disorders are thought to be related to the dysfunction of the liver, including systemic lupus erythematosus, multiple sclerosis, and heart failure. Thus, the liver plays a role in remote immune regulation and is intricately linked with systemic immunity. This review provides a comprehensive overview of the liver remote regulation of the body’s innate and adaptive immunity regarding to main areas: immune-related molecules secreted by the liver and the liver-resident cells. Additionally, we assessed the influence of the liver on various facets of systemic immune-related diseases, offering insights into the clinical application of target therapies for liver immune regulation, as well as future developmental trends. |
| first_indexed | 2024-03-09T00:03:21Z |
| format | Article |
| id | doaj.art-c1ffc75b8a6f409eb70eede285dbcac1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T00:03:21Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c1ffc75b8a6f409eb70eede285dbcac12023-12-12T15:00:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.13141231314123Interorgan communication with the liver: novel mechanisms and therapeutic targetsJiulu Zhao0Jiulu Zhao1Xi Zhang2Xi Zhang3Yuan Li4Yuan Li5Jizhang Yu6Jizhang Yu7Zhang Chen8Zhang Chen9Yuqing Niu10Yuqing Niu11Shuan Ran12Shuan Ran13Song Wang14Song Wang15Weicong Ye16Weicong Ye17Zilong Luo18Zilong Luo19Xiaohan Li20Xiaohan Li21Yanglin Hao22Yanglin Hao23Junjie Zong24Junjie Zong25Chengkun Xia26Jiahong Xia27Jiahong Xia28Jiahong Xia29Jie Wu30Jie Wu31Jie Wu32Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Organ Transplantation, Ministry of Education, National Health Commission Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCenter for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Organ Transplantation, Ministry of Education, National Health Commission Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, ChinaThe liver is a multifunctional organ that plays crucial roles in numerous physiological processes, such as production of bile and proteins for blood plasma, regulation of blood levels of amino acids, processing of hemoglobin, clearance of metabolic waste, maintenance of glucose, etc. Therefore, the liver is essential for the homeostasis of organisms. With the development of research on the liver, there is growing concern about its effect on immune cells of innate and adaptive immunity. For example, the liver regulates the proliferation, differentiation, and effector functions of immune cells through various secreted proteins (also known as “hepatokines”). As a result, the liver is identified as an important regulator of the immune system. Furthermore, many diseases resulting from immune disorders are thought to be related to the dysfunction of the liver, including systemic lupus erythematosus, multiple sclerosis, and heart failure. Thus, the liver plays a role in remote immune regulation and is intricately linked with systemic immunity. This review provides a comprehensive overview of the liver remote regulation of the body’s innate and adaptive immunity regarding to main areas: immune-related molecules secreted by the liver and the liver-resident cells. Additionally, we assessed the influence of the liver on various facets of systemic immune-related diseases, offering insights into the clinical application of target therapies for liver immune regulation, as well as future developmental trends.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1314123/fullliverorgan communicationhepatokineimmunityimmune homeostasisimmune cells |
| spellingShingle | Jiulu Zhao Jiulu Zhao Xi Zhang Xi Zhang Yuan Li Yuan Li Jizhang Yu Jizhang Yu Zhang Chen Zhang Chen Yuqing Niu Yuqing Niu Shuan Ran Shuan Ran Song Wang Song Wang Weicong Ye Weicong Ye Zilong Luo Zilong Luo Xiaohan Li Xiaohan Li Yanglin Hao Yanglin Hao Junjie Zong Junjie Zong Chengkun Xia Jiahong Xia Jiahong Xia Jiahong Xia Jie Wu Jie Wu Jie Wu Interorgan communication with the liver: novel mechanisms and therapeutic targets Frontiers in Immunology liver organ communication hepatokine immunity immune homeostasis immune cells |
| title | Interorgan communication with the liver: novel mechanisms and therapeutic targets |
| title_full | Interorgan communication with the liver: novel mechanisms and therapeutic targets |
| title_fullStr | Interorgan communication with the liver: novel mechanisms and therapeutic targets |
| title_full_unstemmed | Interorgan communication with the liver: novel mechanisms and therapeutic targets |
| title_short | Interorgan communication with the liver: novel mechanisms and therapeutic targets |
| title_sort | interorgan communication with the liver novel mechanisms and therapeutic targets |
| topic | liver organ communication hepatokine immunity immune homeostasis immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1314123/full |
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