Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number.
Although highly conformal dose distributions can be achieved by IMRT planning, this often requires a large number of segments or beams, resulting in increased treatment times. While flattening-filter-free beams offer a higher dose rate, even more segments may be required to create homogeneous target...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3983129?pdf=render |
| _version_ | 1811262448307535872 |
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| author | Yvonne Dzierma Frank G Nuesken Jochen Fleckenstein Patrick Melchior Norbert P Licht Christian Rübe |
| author_facet | Yvonne Dzierma Frank G Nuesken Jochen Fleckenstein Patrick Melchior Norbert P Licht Christian Rübe |
| author_sort | Yvonne Dzierma |
| collection | DOAJ |
| description | Although highly conformal dose distributions can be achieved by IMRT planning, this often requires a large number of segments or beams, resulting in increased treatment times. While flattening-filter-free beams offer a higher dose rate, even more segments may be required to create homogeneous target coverage. Therefore, it is worthwhile to systematically investigate the dependence of plan quality on gantry angles and number of segments for flat vs. FFF beams in IMRT planning. For the practical example of hypopharynx cancer, we present a planning study of flat vs. FFF beams using three different configurations of gantry angles and different segment numbers. The two beams are very similar in physical properties, and are hence well-suited for comparative planning. Starting with a set of plans of equal quality for flat and FFF beams, we assess how far the number of segments can be reduced before the plan quality is markedly compromised, and compare monitor units and treatment times for the resulting plans. As long as a sufficiently large number of segments is permitted, all planning scenarios give good results, independently of gantry angles and flat or FFF beams. For smaller numbers of segments, plan quality decreases both for flat and FFF energies; this effect is stronger for fewer gantry angles and for FFF beams. For low segment numbers, FFF plans are generally worse than the corresponding flat beam plans, but they are less sensitive to a decrease in segment number if many gantry angles are used (18 beams); in this case the quality of flat and FFF plans remains comparable even for few segments. |
| first_indexed | 2024-04-12T19:25:30Z |
| format | Article |
| id | doaj.art-c1fff9377e8d4e3f8d1710791f454076 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T19:25:30Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c1fff9377e8d4e3f8d1710791f4540762022-12-22T03:19:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9437110.1371/journal.pone.0094371Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number.Yvonne DziermaFrank G NueskenJochen FleckensteinPatrick MelchiorNorbert P LichtChristian RübeAlthough highly conformal dose distributions can be achieved by IMRT planning, this often requires a large number of segments or beams, resulting in increased treatment times. While flattening-filter-free beams offer a higher dose rate, even more segments may be required to create homogeneous target coverage. Therefore, it is worthwhile to systematically investigate the dependence of plan quality on gantry angles and number of segments for flat vs. FFF beams in IMRT planning. For the practical example of hypopharynx cancer, we present a planning study of flat vs. FFF beams using three different configurations of gantry angles and different segment numbers. The two beams are very similar in physical properties, and are hence well-suited for comparative planning. Starting with a set of plans of equal quality for flat and FFF beams, we assess how far the number of segments can be reduced before the plan quality is markedly compromised, and compare monitor units and treatment times for the resulting plans. As long as a sufficiently large number of segments is permitted, all planning scenarios give good results, independently of gantry angles and flat or FFF beams. For smaller numbers of segments, plan quality decreases both for flat and FFF energies; this effect is stronger for fewer gantry angles and for FFF beams. For low segment numbers, FFF plans are generally worse than the corresponding flat beam plans, but they are less sensitive to a decrease in segment number if many gantry angles are used (18 beams); in this case the quality of flat and FFF plans remains comparable even for few segments.http://europepmc.org/articles/PMC3983129?pdf=render |
| spellingShingle | Yvonne Dzierma Frank G Nuesken Jochen Fleckenstein Patrick Melchior Norbert P Licht Christian Rübe Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number. PLoS ONE |
| title | Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number. |
| title_full | Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number. |
| title_fullStr | Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number. |
| title_full_unstemmed | Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number. |
| title_short | Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number. |
| title_sort | comparative planning of flattening filter free and flat beam imrt for hypopharynx cancer as a function of beam and segment number |
| url | http://europepmc.org/articles/PMC3983129?pdf=render |
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