Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline
Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently gained increasing attention as an alternative...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-05-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00144/full |
| _version_ | 1819134869063598080 |
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| author | Frank eFreyer Frank eFreyer Frank eFreyer Matthias eReinacher Matthias eReinacher Guido eNolte Hubert R Dinse Petra eRitter Petra eRitter Petra eRitter Petra eRitter |
| author_facet | Frank eFreyer Frank eFreyer Frank eFreyer Matthias eReinacher Matthias eReinacher Guido eNolte Hubert R Dinse Petra eRitter Petra eRitter Petra eRitter Petra eRitter |
| author_sort | Frank eFreyer |
| collection | DOAJ |
| description | Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently gained increasing attention as an alternative to countervail the sensory decline by improving perceptual abilities without the need of active participation. A particularly effective type of high-frequency RSS, utilizing Hebbian learning principles, improves perceptual acuity as well as sensorimotor functions and has been successfully applied to treat chronic stroke patients and elderly subjects. High-frequency RSS has been shown to induce plastic changes of somatosensory cortex such as representational map reorganization, but its impact on the brain’s ongoing network activity and resting-state functional connectivity has not been investigated so far. Here, we applied high-frequency RSS in healthy human subjects and analyzed resting state Electroencephalography (EEG) functional connectivity patterns before and after RSS by means of imaginary coherency (ImCoh), a frequency-specific connectivity measure which is known to reduce overestimation biases due to volume conduction and common reference. Thirty minutes of passive high-frequency RSS lead to significant ImCoh-changes of the resting state mu-rhythm in the individual upper alpha frequency band within distributed sensory and motor cortical areas. These stimulation induced distributed functional connectivity changes likely underlie the previously observed improvement in sensorimotor integration. |
| first_indexed | 2024-12-22T10:10:02Z |
| format | Article |
| id | doaj.art-c2032acaca834d0e96a7e31667990b3b |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T10:10:02Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-c2032acaca834d0e96a7e31667990b3b2022-12-21T18:29:53ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612012-05-01610.3389/fnhum.2012.0014420829Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor declineFrank eFreyer0Frank eFreyer1Frank eFreyer2Matthias eReinacher3Matthias eReinacher4Guido eNolte5Hubert R Dinse6Petra eRitter7Petra eRitter8Petra eRitter9Petra eRitter10Charite University MedicineRuhr-UniversityBernstein Focus State Dependencies of Learning & Bernstein Center for Computational NeuroscienceCharite University MedicineBernstein Focus State Dependencies of Learning & Bernstein Center for Computational NeuroscienceFraunhofer FIRSTRuhr-UniversityBernstein Focus State Dependencies of Learning & Bernstein Center for Computational NeuroscienceCharite University MedicineMax Planck Institute for Human Cognitive and Brain SciencesBerlin School of Mind and Brain & Mind and Brain Institute, Humboldt UniversityNeurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently gained increasing attention as an alternative to countervail the sensory decline by improving perceptual abilities without the need of active participation. A particularly effective type of high-frequency RSS, utilizing Hebbian learning principles, improves perceptual acuity as well as sensorimotor functions and has been successfully applied to treat chronic stroke patients and elderly subjects. High-frequency RSS has been shown to induce plastic changes of somatosensory cortex such as representational map reorganization, but its impact on the brain’s ongoing network activity and resting-state functional connectivity has not been investigated so far. Here, we applied high-frequency RSS in healthy human subjects and analyzed resting state Electroencephalography (EEG) functional connectivity patterns before and after RSS by means of imaginary coherency (ImCoh), a frequency-specific connectivity measure which is known to reduce overestimation biases due to volume conduction and common reference. Thirty minutes of passive high-frequency RSS lead to significant ImCoh-changes of the resting state mu-rhythm in the individual upper alpha frequency band within distributed sensory and motor cortical areas. These stimulation induced distributed functional connectivity changes likely underlie the previously observed improvement in sensorimotor integration.http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00144/fullEEGplasticityfunctional connectivityresting statesensory stimulationsensorimotor |
| spellingShingle | Frank eFreyer Frank eFreyer Frank eFreyer Matthias eReinacher Matthias eReinacher Guido eNolte Hubert R Dinse Petra eRitter Petra eRitter Petra eRitter Petra eRitter Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline Frontiers in Human Neuroscience EEG plasticity functional connectivity resting state sensory stimulation sensorimotor |
| title | Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline |
| title_full | Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline |
| title_fullStr | Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline |
| title_full_unstemmed | Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline |
| title_short | Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline |
| title_sort | repetitive tactile stimulation changes resting state functional connectivity implications for treatment of sensorimotor decline |
| topic | EEG plasticity functional connectivity resting state sensory stimulation sensorimotor |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00144/full |
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