Ischemic Preconditioning Modulates the Peripheral Innate Immune System to Promote Anti-Inflammatory and Protective Responses in Mice Subjected to Focal Cerebral Ischemia

Ischemic Preconditioning Modulates the Peripheral Innate Immune System to Promote Anti-Inflammatory and Protective Responses in Mice Subjected to Focal Cerebral Ischemia

The development of tolerance triggered by a sublethal ischemic episode (preconditioning, PC) involves a complex crosstalk between neurons, astrocytes and microglia, although the role of the peripheral immune system in this context is largely unexplored. Here, we report that severe cerebral ischemia...

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Bibliographic Details
Main Authors: Diana Amantea, Daniele La Russa, Marialaura Frisina, Francesca Giordano, Chiara Di Santo, Maria Luisa Panno, Giuseppe Pignataro, Giacinto Bagetta
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
immune system
ischemic stroke
ischemic tolerance
preconditioning
miRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.825834/full

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