Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas
Introduction Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients. The purpose of this research is to investigate whether mucin 1 expression detected by immunohistochemistry in lymph nodes correlates with LNM,...
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| Format: | Article |
| Jezik: | English |
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Termedia Publishing House
2019-10-01
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| Serija: | Archives of Medical Science |
| Teme: | |
| Online dostop: | https://www.archivesofmedicalscience.com/Mucin-1-expression-correlation-with-lymph-node-metastasis-and-micrometastasis-and,112410,0,2.html |
| _version_ | 1827620468032536576 |
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| author | Fei Yang Zhe Li Jing-Bo Shao Wei Gao Zhi-Gang Sun |
| author_facet | Fei Yang Zhe Li Jing-Bo Shao Wei Gao Zhi-Gang Sun |
| author_sort | Fei Yang |
| collection | DOAJ |
| description | Introduction
Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients. The purpose of this research is to investigate whether mucin 1 expression detected by immunohistochemistry in lymph nodes correlates with LNM, LNMM and prognosis in ESCC patients.
Material and methods
There were 92 ESCC patients enrolled in the research, and 1382 lymph nodes were obtained from these 92 patients. All lymph nodes were immunohistochemically analyzed using an anticytokeratin and mucin 1 antibody cocktail.
Results
In the pN1-2 patients’ group, 68 lymph nodes from 15 patients had tumor metastasis. All these 68 tumor metastatic lymph nodes were positive for mucin 1. Mucin 1 was detected in another 231 lymph nodes and among them, 3 (3/231 1.3%) lymph nodes from 2 (2/15 13.3%) patients were positive for mucin 1. In 77 pN0 patients, mucin 1 was detected in 1083 lymph nodes from the 77 patients; 17 (17/1083 1.6%) lymph nodes from 15 (15/77 19.5%) patients were positive for mucin 1. The 5-year survival rate was 39.1%, and it was significantly related to tumor invasion (pT, p < 0.05), lymph node metastasis (pN, p < 0.01), pTNM stage (p < 0.01) and mucin 1 expression (p < 0.01). Cox regression of multivariate analysis demonstrated that mucin 1 expression and pT were independent prognostic factors.
Conclusions
Mucin 1 expression was related to LNM and LNMM and poor prognosis in ESCC patients. Immunohistochemistry for mucin 1 can be applied for the detection of LNM and LNMM. |
| first_indexed | 2024-03-09T10:47:43Z |
| format | Article |
| id | doaj.art-c2081d2e56d44555a28beddbfee329fa |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:47:43Z |
| publishDate | 2019-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-c2081d2e56d44555a28beddbfee329fa2023-12-01T09:51:47ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512019-10-0119363864410.5114/aoms.2019.89219112410Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomasFei Yang0Zhe Li1Jing-Bo Shao2Wei Gao3Zhi-Gang Sun4Department of Pathology, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Medical Examination, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, ChinaWeifang Medical University, Weifang, Shandong Province, ChinaDepartment of Pathology, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, ChinaIntroduction Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients. The purpose of this research is to investigate whether mucin 1 expression detected by immunohistochemistry in lymph nodes correlates with LNM, LNMM and prognosis in ESCC patients. Material and methods There were 92 ESCC patients enrolled in the research, and 1382 lymph nodes were obtained from these 92 patients. All lymph nodes were immunohistochemically analyzed using an anticytokeratin and mucin 1 antibody cocktail. Results In the pN1-2 patients’ group, 68 lymph nodes from 15 patients had tumor metastasis. All these 68 tumor metastatic lymph nodes were positive for mucin 1. Mucin 1 was detected in another 231 lymph nodes and among them, 3 (3/231 1.3%) lymph nodes from 2 (2/15 13.3%) patients were positive for mucin 1. In 77 pN0 patients, mucin 1 was detected in 1083 lymph nodes from the 77 patients; 17 (17/1083 1.6%) lymph nodes from 15 (15/77 19.5%) patients were positive for mucin 1. The 5-year survival rate was 39.1%, and it was significantly related to tumor invasion (pT, p < 0.05), lymph node metastasis (pN, p < 0.01), pTNM stage (p < 0.01) and mucin 1 expression (p < 0.01). Cox regression of multivariate analysis demonstrated that mucin 1 expression and pT were independent prognostic factors. Conclusions Mucin 1 expression was related to LNM and LNMM and poor prognosis in ESCC patients. Immunohistochemistry for mucin 1 can be applied for the detection of LNM and LNMM.https://www.archivesofmedicalscience.com/Mucin-1-expression-correlation-with-lymph-node-metastasis-and-micrometastasis-and,112410,0,2.htmlmucin 1lymph node metastasislymph node micrometastasisesophageal squamous cell carcinoma |
| spellingShingle | Fei Yang Zhe Li Jing-Bo Shao Wei Gao Zhi-Gang Sun Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas Archives of Medical Science mucin 1 lymph node metastasis lymph node micrometastasis esophageal squamous cell carcinoma |
| title | Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas |
| title_full | Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas |
| title_fullStr | Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas |
| title_full_unstemmed | Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas |
| title_short | Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas |
| title_sort | mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas |
| topic | mucin 1 lymph node metastasis lymph node micrometastasis esophageal squamous cell carcinoma |
| url | https://www.archivesofmedicalscience.com/Mucin-1-expression-correlation-with-lymph-node-metastasis-and-micrometastasis-and,112410,0,2.html |
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