Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects
Research in the cognitive neuroscience field has shown that individuals with a stronger attention bias for negative information had higher depression risk, which may be the underlying pathogenesis of depression. This dysfunction of affect-biased attention also represents a decline in emotion regulat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.894798/full |
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| author | Shuang Liu Siyu Zhai Dongyue Guo Sitong Chen Yuchen He Yufeng Ke Dong Ming Dong Ming |
| author_facet | Shuang Liu Siyu Zhai Dongyue Guo Sitong Chen Yuchen He Yufeng Ke Dong Ming Dong Ming |
| author_sort | Shuang Liu |
| collection | DOAJ |
| description | Research in the cognitive neuroscience field has shown that individuals with a stronger attention bias for negative information had higher depression risk, which may be the underlying pathogenesis of depression. This dysfunction of affect-biased attention also represents a decline in emotion regulation ability. Clinical studies have suggested that transcranial direct current stimulation (tDCS) treatment can improve the symptoms of depression, yet the neural mechanism behind this improvement is still veiled. This study aims to investigate the effects of tDCS on affect-biased attention. A sample of healthy participants received 20 min active (n = 22) or sham tDCS (n = 19) over the left dorsolateral prefrontal cortex (DLPFC) for 7 consecutive days. Electroencephalographic (EEG) signals were recorded while performing the rest task and emotional oddball task. The oddball task required response to pictures of the target (positive or negative) emotional facial stimuli and neglecting distracter (negative or positive) or standard (neutral) stimuli. Welch power spectrum estimation algorithm was applied to calculate frontal alpha asymmetry (FAA) in the rest task, and the overlapping averaging method was used to extract event-related potentials (ERP) components in the oddball task. Compared to sham tDCS, active tDCS caused an obvious increment in FAA in connection with emotion regulation (p < 0.05). Also, participants in the active tDCS group show greater P3 amplitudes following positive targets (p < 0.05) and greater N2 amplitudes following negative distracters (p < 0.05), reflecting emotion-related attention biases. These results offer valuable insights into the relationship between affect-biased attention and the effects of tDCS, which may be of assistance in exploring the neuropathological mechanism of depression and anxiety and new treatment strategies for tDCS. |
| first_indexed | 2024-04-13T19:11:41Z |
| format | Article |
| id | doaj.art-c209999cddb241ae85d3cc13513d85c6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T19:11:41Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-c209999cddb241ae85d3cc13513d85c62022-12-22T02:33:50ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-06-011610.3389/fnins.2022.894798894798Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy SubjectsShuang Liu0Siyu Zhai1Dongyue Guo2Sitong Chen3Yuchen He4Yufeng Ke5Dong Ming6Dong Ming7Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaSchool of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaSchool of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, ChinaResearch in the cognitive neuroscience field has shown that individuals with a stronger attention bias for negative information had higher depression risk, which may be the underlying pathogenesis of depression. This dysfunction of affect-biased attention also represents a decline in emotion regulation ability. Clinical studies have suggested that transcranial direct current stimulation (tDCS) treatment can improve the symptoms of depression, yet the neural mechanism behind this improvement is still veiled. This study aims to investigate the effects of tDCS on affect-biased attention. A sample of healthy participants received 20 min active (n = 22) or sham tDCS (n = 19) over the left dorsolateral prefrontal cortex (DLPFC) for 7 consecutive days. Electroencephalographic (EEG) signals were recorded while performing the rest task and emotional oddball task. The oddball task required response to pictures of the target (positive or negative) emotional facial stimuli and neglecting distracter (negative or positive) or standard (neutral) stimuli. Welch power spectrum estimation algorithm was applied to calculate frontal alpha asymmetry (FAA) in the rest task, and the overlapping averaging method was used to extract event-related potentials (ERP) components in the oddball task. Compared to sham tDCS, active tDCS caused an obvious increment in FAA in connection with emotion regulation (p < 0.05). Also, participants in the active tDCS group show greater P3 amplitudes following positive targets (p < 0.05) and greater N2 amplitudes following negative distracters (p < 0.05), reflecting emotion-related attention biases. These results offer valuable insights into the relationship between affect-biased attention and the effects of tDCS, which may be of assistance in exploring the neuropathological mechanism of depression and anxiety and new treatment strategies for tDCS.https://www.frontiersin.org/articles/10.3389/fnins.2022.894798/fulltDCSDLPFCattention biasERPemotion regulation |
| spellingShingle | Shuang Liu Siyu Zhai Dongyue Guo Sitong Chen Yuchen He Yufeng Ke Dong Ming Dong Ming Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects Frontiers in Neuroscience tDCS DLPFC attention bias ERP emotion regulation |
| title | Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects |
| title_full | Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects |
| title_fullStr | Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects |
| title_full_unstemmed | Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects |
| title_short | Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects |
| title_sort | transcranial direct current stimulation over the left dorsolateral prefrontal cortex reduced attention bias toward negative facial expression a pilot study in healthy subjects |
| topic | tDCS DLPFC attention bias ERP emotion regulation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.894798/full |
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