Redox-Mediated Inactivation of the Transcriptional Repressor RcrR is Responsible for Uropathogenic Escherichia coli’s Increased Resistance to Reactive Chlorine Species

Redox-Mediated Inactivation of the Transcriptional Repressor RcrR is Responsible for Uropathogenic Escherichia coli’s Increased Resistance to Reactive Chlorine Species

ABSTRACT The ability to overcome stressful environments is critical for pathogen survival in the host. One challenge for bacteria is the exposure to reactive chlorine species (RCS), which are generated by innate immune cells as a critical part of the oxidative burst. Hypochlorous acid (HOCl) is the...

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Podrobná bibliografie
Hlavní autoři: Sadia Sultana, Mary E. Crompton, Kennadi Meurer, Olivia Jankiewicz, Grace H. Morales, Colton Johnson, Elise Horbach, Kevin Pierre Hoffmann, Pooja Kr, Ritika Shah, Greg M. Anderson, Nathan T. Mortimer, Jonathan E. Schmitz, Maria Hadjifrangiskou, Alessandro Foti, Jan-Ulrik Dahl
Médium: Článek
Jazyk:English
Vydáno: American Society for Microbiology 2022-10-01
Edice:mBio
Témata:
bacterial defense systems
hypochlorous acid
oxidative stress
reactive chlorine species
transcriptional regulation
On-line přístup:https://journals.asm.org/doi/10.1128/mbio.01926-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01926-22

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