A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant
Posttransplant lymphoproliferative disorders (PTLD) represent a rare and potentially life-threatening complication after liver transplantation. Classical Hodgkin lymphoma (cHL), with an incidence of approximately 1.8–3.4% of all PTLD cases, represents a minority of PTLD, mainly presenting as a late...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2017-10-01
|
| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/481452 |
| _version_ | 1811303007576391680 |
|---|---|
| author | L. Zhang R. Pereira Mestre F. Bihl M. Bühler B. Vannata A. Stathis |
| author_facet | L. Zhang R. Pereira Mestre F. Bihl M. Bühler B. Vannata A. Stathis |
| author_sort | L. Zhang |
| collection | DOAJ |
| description | Posttransplant lymphoproliferative disorders (PTLD) represent a rare and potentially life-threatening complication after liver transplantation. Classical Hodgkin lymphoma (cHL), with an incidence of approximately 1.8–3.4% of all PTLD cases, represents a minority of PTLD, mainly presenting as a late transplant complication. The main risk factors for the development of PTLD are Epstein-Barr virus (EBV) infection and intensive immunosuppression. However, other risk factors like hepatitis C virus may, together with EBV infection, contribute to the development of PTLD. Here we present a case of late-onset EBV-positive cHL that occurred 10 years after an unrelated donor liver transplantation. To our knowledge, this is the first report of cHL occurring with such a long interval after liver transplantation. Given the low incidence of cHL PTLD, there is little information regarding pathology, clinical characteristics, and management of this disease. The development of individual, risk-adapted treatments may improve the long-term outcome of cHL PTLD. |
| first_indexed | 2024-04-13T07:40:36Z |
| format | Article |
| id | doaj.art-c20d26242c9c421a86fb8a908376e293 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T07:40:36Z |
| publishDate | 2017-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-c20d26242c9c421a86fb8a908376e2932022-12-22T02:55:56ZengKarger PublishersCase Reports in Oncology1662-65752017-10-0110392392710.1159/000481452481452A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver TransplantL. ZhangR. Pereira MestreF. BihlM. BühlerB. VannataA. StathisPosttransplant lymphoproliferative disorders (PTLD) represent a rare and potentially life-threatening complication after liver transplantation. Classical Hodgkin lymphoma (cHL), with an incidence of approximately 1.8–3.4% of all PTLD cases, represents a minority of PTLD, mainly presenting as a late transplant complication. The main risk factors for the development of PTLD are Epstein-Barr virus (EBV) infection and intensive immunosuppression. However, other risk factors like hepatitis C virus may, together with EBV infection, contribute to the development of PTLD. Here we present a case of late-onset EBV-positive cHL that occurred 10 years after an unrelated donor liver transplantation. To our knowledge, this is the first report of cHL occurring with such a long interval after liver transplantation. Given the low incidence of cHL PTLD, there is little information regarding pathology, clinical characteristics, and management of this disease. The development of individual, risk-adapted treatments may improve the long-term outcome of cHL PTLD.https://www.karger.com/Article/FullText/481452Hodgkin lymphomaPosttransplant lymphoproliferative disordersTransplantationHepatitis C virusEpstein-Barr virusImmunosuppression |
| spellingShingle | L. Zhang R. Pereira Mestre F. Bihl M. Bühler B. Vannata A. Stathis A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant Case Reports in Oncology Hodgkin lymphoma Posttransplant lymphoproliferative disorders Transplantation Hepatitis C virus Epstein-Barr virus Immunosuppression |
| title | A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant |
| title_full | A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant |
| title_fullStr | A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant |
| title_full_unstemmed | A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant |
| title_short | A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant |
| title_sort | rare case of classical hodgkin lymphoma diagnosed 10 years after liver transplant |
| topic | Hodgkin lymphoma Posttransplant lymphoproliferative disorders Transplantation Hepatitis C virus Epstein-Barr virus Immunosuppression |
| url | https://www.karger.com/Article/FullText/481452 |
| work_keys_str_mv | AT lzhang ararecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT rpereiramestre ararecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT fbihl ararecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT mbuhler ararecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT bvannata ararecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT astathis ararecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT lzhang rarecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT rpereiramestre rarecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT fbihl rarecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT mbuhler rarecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT bvannata rarecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant AT astathis rarecaseofclassicalhodgkinlymphomadiagnosed10yearsafterlivertransplant |