Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.
Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-d...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3759384?pdf=render |
| _version_ | 1818286915817832448 |
|---|---|
| author | Miriam Sciaccaluga Giuseppina D'Alessandro Francesca Pagani Giuseppina Ferrara Nadia Lopez Tracy Warr Paolo Gorello Alessandra Porzia Fabrizio Mainiero Antonio Santoro Vincenzo Esposito Giampaolo Cantore Emilia Castigli Cristina Limatola |
| author_facet | Miriam Sciaccaluga Giuseppina D'Alessandro Francesca Pagani Giuseppina Ferrara Nadia Lopez Tracy Warr Paolo Gorello Alessandra Porzia Fabrizio Mainiero Antonio Santoro Vincenzo Esposito Giampaolo Cantore Emilia Castigli Cristina Limatola |
| author_sort | Miriam Sciaccaluga |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the pro-migratory action of CXCL12 on GBM cells in vitro and in vivo is recognized, the molecular mechanisms involved are not clearly identified. In fact the signaling pathways involved in the pro-migratory action of CXCL12 may differ in individual glioblastoma and integrate with those resulting from abnormal expression and activation of growth factor receptors. In this study we investigated whether some of the receptor tyrosine kinases commonly expressed in GBM cells could cooperate with CXCL12/CXCR4 in their migratory behavior. Our results show a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis. |
| first_indexed | 2024-12-13T01:32:11Z |
| format | Article |
| id | doaj.art-c20e6b5ac06749638ebb30238b859900 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T01:32:11Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c20e6b5ac06749638ebb30238b8599002022-12-22T00:03:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7342610.1371/journal.pone.0073426Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.Miriam SciaccalugaGiuseppina D'AlessandroFrancesca PaganiGiuseppina FerraraNadia LopezTracy WarrPaolo GorelloAlessandra PorziaFabrizio MainieroAntonio SantoroVincenzo EspositoGiampaolo CantoreEmilia CastigliCristina LimatolaGlioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the pro-migratory action of CXCL12 on GBM cells in vitro and in vivo is recognized, the molecular mechanisms involved are not clearly identified. In fact the signaling pathways involved in the pro-migratory action of CXCL12 may differ in individual glioblastoma and integrate with those resulting from abnormal expression and activation of growth factor receptors. In this study we investigated whether some of the receptor tyrosine kinases commonly expressed in GBM cells could cooperate with CXCL12/CXCR4 in their migratory behavior. Our results show a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis.http://europepmc.org/articles/PMC3759384?pdf=render |
| spellingShingle | Miriam Sciaccaluga Giuseppina D'Alessandro Francesca Pagani Giuseppina Ferrara Nadia Lopez Tracy Warr Paolo Gorello Alessandra Porzia Fabrizio Mainiero Antonio Santoro Vincenzo Esposito Giampaolo Cantore Emilia Castigli Cristina Limatola Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration. PLoS ONE |
| title | Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration. |
| title_full | Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration. |
| title_fullStr | Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration. |
| title_full_unstemmed | Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration. |
| title_short | Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration. |
| title_sort | functional cross talk between cxcr4 and pdgfr on glioblastoma cells is essential for migration |
| url | http://europepmc.org/articles/PMC3759384?pdf=render |
| work_keys_str_mv | AT miriamsciaccaluga functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT giuseppinadalessandro functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT francescapagani functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT giuseppinaferrara functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT nadialopez functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT tracywarr functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT paologorello functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT alessandraporzia functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT fabriziomainiero functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT antoniosantoro functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT vincenzoesposito functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT giampaolocantore functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT emiliacastigli functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration AT cristinalimatola functionalcrosstalkbetweencxcr4andpdgfronglioblastomacellsisessentialformigration |