Serum folic acid: an effective indicator for arteriogenic erectile dysfunction
BackgroundThe present study is the first to explore the correlation between serum folic acid (FA) level and penile arterial peak systolic velocity (PSV) as measured via penile color Doppler ultrasonography (PDU), which directly reflects endothelial function in the penile artery.Materials and methods...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1080188/full |
| _version_ | 1797773432587288576 |
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| author | Xingliang Feng Xingliang Feng Yangyang Mei Pinpeng Xie Pinpeng Xie Zhaoyu Xing Zhaoyu Xing Xiaogang Wang Xiaogang Wang Li Cui Li Cui Renfang Xu Renfang Xu |
| author_facet | Xingliang Feng Xingliang Feng Yangyang Mei Pinpeng Xie Pinpeng Xie Zhaoyu Xing Zhaoyu Xing Xiaogang Wang Xiaogang Wang Li Cui Li Cui Renfang Xu Renfang Xu |
| author_sort | Xingliang Feng |
| collection | DOAJ |
| description | BackgroundThe present study is the first to explore the correlation between serum folic acid (FA) level and penile arterial peak systolic velocity (PSV) as measured via penile color Doppler ultrasonography (PDU), which directly reflects endothelial function in the penile artery.Materials and methodsA total of 244 consecutive erectile dysfunction (ED) patients and 72 healthy controls, recruited from the Andrology department and the Healthy Physical Examination Center of our hospital, respectively, from June 2020 to April 2022, were included in the study. Serum FA was measured in ED patients and healthy controls, and PDU examinations were conducted for all eligible ED patients. The Pearson method was used to evaluate the correlation between FA levels and PDU parameters in ED patients. A receiver operating characteristic (ROC) curve analysis was also performed to calculate the sensitivity and specificity of these parameters for prediction of arteriogenic ED.ResultsAfter the PDU test, the average serum FA level among patients diagnosed with arteriogenic ED was 8.08 ± 2.64 ng/ml, lower than the average of 10.78 ± 2.87 ng/ml among healthy controls. There were no statistically significant inter-group differences on any basic parameters, including age, body mass index, fasting blood glucose, total cholesterol, and triglyceride. For further analysis, we divided the arteriogenic ED group into three subgroups by PSV range to compare serum FA levels among these subgroups. The mean FA levels in each of these groups were 5.97 ± 1.51ng/ml, and 8.21 ± 2.37ng/ml, and 10.55 ± 2.56ng/ml, while the corresponding PSV values were 15.75 ± 2.39cm/s, 23.53 ± 2.19cm/s, and 32.72 ± 1.64cm/s. Overall, a positive correlation between PSV and FA level was found among patients with arteriogenic ED (r=0.605, P<0.001). Furthermore, when FA level was used, with a cut-off value of 10.045 ng/ml, as a criterion to distinguish patients with arteriogenic ED from healthy controls, the area under the curve (AUC) was 0.772 (95% confidential interval: [0.696, 0.848]), for a sensitivity of 0.611 and specificity of 0.824.ConclusionSerum FA level is positively correlated with PSV in ED patients, and has the ability to distinguish patients with arteriogenic ED from healthy controls. Taking these findings together, FA deficiency should be regarded as an independent risk factor for arteriogenic ED. |
| first_indexed | 2024-03-12T22:06:23Z |
| format | Article |
| id | doaj.art-c20ea57f0dac4ae38e16ab325a21d22a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T22:06:23Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-c20ea57f0dac4ae38e16ab325a21d22a2023-07-24T13:33:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.10801881080188Serum folic acid: an effective indicator for arteriogenic erectile dysfunctionXingliang Feng0Xingliang Feng1Yangyang Mei2Pinpeng Xie3Pinpeng Xie4Zhaoyu Xing5Zhaoyu Xing6Xiaogang Wang7Xiaogang Wang8Li Cui9Li Cui10Renfang Xu11Renfang Xu12Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Clinical Medicine, The Second School of Clinical Medicine, Anhui Medical University, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaBackgroundThe present study is the first to explore the correlation between serum folic acid (FA) level and penile arterial peak systolic velocity (PSV) as measured via penile color Doppler ultrasonography (PDU), which directly reflects endothelial function in the penile artery.Materials and methodsA total of 244 consecutive erectile dysfunction (ED) patients and 72 healthy controls, recruited from the Andrology department and the Healthy Physical Examination Center of our hospital, respectively, from June 2020 to April 2022, were included in the study. Serum FA was measured in ED patients and healthy controls, and PDU examinations were conducted for all eligible ED patients. The Pearson method was used to evaluate the correlation between FA levels and PDU parameters in ED patients. A receiver operating characteristic (ROC) curve analysis was also performed to calculate the sensitivity and specificity of these parameters for prediction of arteriogenic ED.ResultsAfter the PDU test, the average serum FA level among patients diagnosed with arteriogenic ED was 8.08 ± 2.64 ng/ml, lower than the average of 10.78 ± 2.87 ng/ml among healthy controls. There were no statistically significant inter-group differences on any basic parameters, including age, body mass index, fasting blood glucose, total cholesterol, and triglyceride. For further analysis, we divided the arteriogenic ED group into three subgroups by PSV range to compare serum FA levels among these subgroups. The mean FA levels in each of these groups were 5.97 ± 1.51ng/ml, and 8.21 ± 2.37ng/ml, and 10.55 ± 2.56ng/ml, while the corresponding PSV values were 15.75 ± 2.39cm/s, 23.53 ± 2.19cm/s, and 32.72 ± 1.64cm/s. Overall, a positive correlation between PSV and FA level was found among patients with arteriogenic ED (r=0.605, P<0.001). Furthermore, when FA level was used, with a cut-off value of 10.045 ng/ml, as a criterion to distinguish patients with arteriogenic ED from healthy controls, the area under the curve (AUC) was 0.772 (95% confidential interval: [0.696, 0.848]), for a sensitivity of 0.611 and specificity of 0.824.ConclusionSerum FA level is positively correlated with PSV in ED patients, and has the ability to distinguish patients with arteriogenic ED from healthy controls. Taking these findings together, FA deficiency should be regarded as an independent risk factor for arteriogenic ED.https://www.frontiersin.org/articles/10.3389/fendo.2023.1080188/fullfolic acidarteriogenic erectile dysfunctionpeak systolic velocitypenile color Doppler ultrasonographyeffective indicators |
| spellingShingle | Xingliang Feng Xingliang Feng Yangyang Mei Pinpeng Xie Pinpeng Xie Zhaoyu Xing Zhaoyu Xing Xiaogang Wang Xiaogang Wang Li Cui Li Cui Renfang Xu Renfang Xu Serum folic acid: an effective indicator for arteriogenic erectile dysfunction Frontiers in Endocrinology folic acid arteriogenic erectile dysfunction peak systolic velocity penile color Doppler ultrasonography effective indicators |
| title | Serum folic acid: an effective indicator for arteriogenic erectile dysfunction |
| title_full | Serum folic acid: an effective indicator for arteriogenic erectile dysfunction |
| title_fullStr | Serum folic acid: an effective indicator for arteriogenic erectile dysfunction |
| title_full_unstemmed | Serum folic acid: an effective indicator for arteriogenic erectile dysfunction |
| title_short | Serum folic acid: an effective indicator for arteriogenic erectile dysfunction |
| title_sort | serum folic acid an effective indicator for arteriogenic erectile dysfunction |
| topic | folic acid arteriogenic erectile dysfunction peak systolic velocity penile color Doppler ultrasonography effective indicators |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1080188/full |
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