Targeting MYC at the intersection between cancer metabolism and oncoimmunology
MYC activation is a known hallmark of cancer as it governs the gene targets involved in various facets of cancer progression. Of interest, MYC governs oncometabolism through the interactions with its partners and cofactors, as well as cancer immunity via its gene targets. Recent investigations have...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1324045/full |
| _version_ | 1797321053473603584 |
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| author | Simran Venkatraman Brinda Balasubramanian Chanitra Thuwajit Jaroslaw Meller Jaroslaw Meller Jaroslaw Meller Rutaiwan Tohtong Somchai Chutipongtanate Somchai Chutipongtanate |
| author_facet | Simran Venkatraman Brinda Balasubramanian Chanitra Thuwajit Jaroslaw Meller Jaroslaw Meller Jaroslaw Meller Rutaiwan Tohtong Somchai Chutipongtanate Somchai Chutipongtanate |
| author_sort | Simran Venkatraman |
| collection | DOAJ |
| description | MYC activation is a known hallmark of cancer as it governs the gene targets involved in various facets of cancer progression. Of interest, MYC governs oncometabolism through the interactions with its partners and cofactors, as well as cancer immunity via its gene targets. Recent investigations have taken interest in characterizing these interactions through multi-Omic approaches, to better understand the vastness of the MYC network. Of the several gene targets of MYC involved in either oncometabolism or oncoimmunology, few of them overlap in function. Prominent interactions have been observed with MYC and HIF-1α, in promoting glucose and glutamine metabolism and activation of antigen presentation on regulatory T cells, and its subsequent metabolic reprogramming. This review explores existing knowledge of the role of MYC in oncometabolism and oncoimmunology. It also unravels how MYC governs transcription and influences cellular metabolism to facilitate the induction of pro- or anti-tumoral immunity. Moreover, considering the significant roles MYC holds in cancer development, the present study discusses effective direct or indirect therapeutic strategies to combat MYC-driven cancer progression. |
| first_indexed | 2024-03-08T04:51:58Z |
| format | Article |
| id | doaj.art-c21297c950af4c5e95402930fd4df6dd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T04:51:58Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c21297c950af4c5e95402930fd4df6dd2024-02-08T04:41:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13240451324045Targeting MYC at the intersection between cancer metabolism and oncoimmunologySimran Venkatraman0Brinda Balasubramanian1Chanitra Thuwajit2Jaroslaw Meller3Jaroslaw Meller4Jaroslaw Meller5Rutaiwan Tohtong6Somchai Chutipongtanate7Somchai Chutipongtanate8Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, ThailandDivision of Cancer and Stem Cells, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, United KingdomDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, United StatesDepartment of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, OH, United StatesDivision of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, ThailandDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, United StatesMilk, microbiome, Immunity and Lactation research for Child Health (MILCH) and Novel Therapeutics Lab, Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, United StatesMYC activation is a known hallmark of cancer as it governs the gene targets involved in various facets of cancer progression. Of interest, MYC governs oncometabolism through the interactions with its partners and cofactors, as well as cancer immunity via its gene targets. Recent investigations have taken interest in characterizing these interactions through multi-Omic approaches, to better understand the vastness of the MYC network. Of the several gene targets of MYC involved in either oncometabolism or oncoimmunology, few of them overlap in function. Prominent interactions have been observed with MYC and HIF-1α, in promoting glucose and glutamine metabolism and activation of antigen presentation on regulatory T cells, and its subsequent metabolic reprogramming. This review explores existing knowledge of the role of MYC in oncometabolism and oncoimmunology. It also unravels how MYC governs transcription and influences cellular metabolism to facilitate the induction of pro- or anti-tumoral immunity. Moreover, considering the significant roles MYC holds in cancer development, the present study discusses effective direct or indirect therapeutic strategies to combat MYC-driven cancer progression.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1324045/fullMYCmetabolismoncoimmunologycancerimmune evasion |
| spellingShingle | Simran Venkatraman Brinda Balasubramanian Chanitra Thuwajit Jaroslaw Meller Jaroslaw Meller Jaroslaw Meller Rutaiwan Tohtong Somchai Chutipongtanate Somchai Chutipongtanate Targeting MYC at the intersection between cancer metabolism and oncoimmunology Frontiers in Immunology MYC metabolism oncoimmunology cancer immune evasion |
| title | Targeting MYC at the intersection between cancer metabolism and oncoimmunology |
| title_full | Targeting MYC at the intersection between cancer metabolism and oncoimmunology |
| title_fullStr | Targeting MYC at the intersection between cancer metabolism and oncoimmunology |
| title_full_unstemmed | Targeting MYC at the intersection between cancer metabolism and oncoimmunology |
| title_short | Targeting MYC at the intersection between cancer metabolism and oncoimmunology |
| title_sort | targeting myc at the intersection between cancer metabolism and oncoimmunology |
| topic | MYC metabolism oncoimmunology cancer immune evasion |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1324045/full |
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