Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study
Geographic atrophy (GA), the late stage of age-related macular degeneration, is a major cause of visual disability whose pathophysiology remains largely unknown. Modern fundus imaging and histology revealed the complexity of the cellular changes that accompanies atrophy. Documenting the activity of...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.868163/full |
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| author | Michel Paques Michel Paques Nathaniel Norberg Céline Chaumette Florian Sennlaub Ethan Rossi Ysé Borella Ysé Borella Kate Grieve Kate Grieve |
| author_facet | Michel Paques Michel Paques Nathaniel Norberg Céline Chaumette Florian Sennlaub Ethan Rossi Ysé Borella Ysé Borella Kate Grieve Kate Grieve |
| author_sort | Michel Paques |
| collection | DOAJ |
| description | Geographic atrophy (GA), the late stage of age-related macular degeneration, is a major cause of visual disability whose pathophysiology remains largely unknown. Modern fundus imaging and histology revealed the complexity of the cellular changes that accompanies atrophy. Documenting the activity of the disease in the margins of atrophy, where the transition from health to disease occurs, would contribute to a better understanding of the progression of GA. Time-lapse imaging facilitates the identification of structural continuities in changing environments. In this retrospective pilot study, we documented the long-term changes in atrophy margins by time-lapse imaging of infrared scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) images in 6 cases of GA covering a mean period of 32.8 months (range, 18–72). The mean interval between imaging sessions was 2.4 months (range, 1.4–3.8). By viewing time-lapse sequences we observed extensive changes in the pattern of marginal hyperreflective spots, which associated fragmentation, increase and/or disappearance. Over the entire span of the follow-up, the most striking changes were those affecting hyperreflective spots closest to margins of atrophy, on the non-atrophic side of the retina; a continuum between the successive positions of some of the hyperreflective spots was detected, both by SLO and OCT. This continuum in their successive positions resulted in a subjective impression of a centrifugal motion of hyperreflective spots ahead of atrophy progression. Such mobilization of hyperreflective spots was detected up to several hundred microns away from atrophic borders. Such process is likely to reflect the inflammatory and degenerative process underlying GA progression and hence deserves further investigations. These results highlight the interest of multimodal time-lapse imaging to document cell-scale dynamics during progression of GA.Clinical Trial Registrationclinicaltrials.gov, identifier: NCT04128150 and NCT04129021. |
| first_indexed | 2024-12-12T11:55:50Z |
| format | Article |
| id | doaj.art-c2132b46a1274176b06de375bee88ff6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T11:55:50Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-c2132b46a1274176b06de375bee88ff62022-12-22T00:25:12ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.868163868163Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot StudyMichel Paques0Michel Paques1Nathaniel Norberg2Céline Chaumette3Florian Sennlaub4Ethan Rossi5Ysé Borella6Ysé Borella7Kate Grieve8Kate Grieve9Paris Eye Imaging Group, Clinical Investigation Center 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne Université, INSERM, Paris, FranceInstitut de la Vision, Paris, FranceParis Eye Imaging Group, Clinical Investigation Center 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne Université, INSERM, Paris, FranceParis Eye Imaging Group, Clinical Investigation Center 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne Université, INSERM, Paris, FranceInstitut de la Vision, Paris, FranceDepartment of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesParis Eye Imaging Group, Clinical Investigation Center 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne Université, INSERM, Paris, FranceInstitut de la Vision, Paris, FranceParis Eye Imaging Group, Clinical Investigation Center 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne Université, INSERM, Paris, FranceInstitut de la Vision, Paris, FranceGeographic atrophy (GA), the late stage of age-related macular degeneration, is a major cause of visual disability whose pathophysiology remains largely unknown. Modern fundus imaging and histology revealed the complexity of the cellular changes that accompanies atrophy. Documenting the activity of the disease in the margins of atrophy, where the transition from health to disease occurs, would contribute to a better understanding of the progression of GA. Time-lapse imaging facilitates the identification of structural continuities in changing environments. In this retrospective pilot study, we documented the long-term changes in atrophy margins by time-lapse imaging of infrared scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) images in 6 cases of GA covering a mean period of 32.8 months (range, 18–72). The mean interval between imaging sessions was 2.4 months (range, 1.4–3.8). By viewing time-lapse sequences we observed extensive changes in the pattern of marginal hyperreflective spots, which associated fragmentation, increase and/or disappearance. Over the entire span of the follow-up, the most striking changes were those affecting hyperreflective spots closest to margins of atrophy, on the non-atrophic side of the retina; a continuum between the successive positions of some of the hyperreflective spots was detected, both by SLO and OCT. This continuum in their successive positions resulted in a subjective impression of a centrifugal motion of hyperreflective spots ahead of atrophy progression. Such mobilization of hyperreflective spots was detected up to several hundred microns away from atrophic borders. Such process is likely to reflect the inflammatory and degenerative process underlying GA progression and hence deserves further investigations. These results highlight the interest of multimodal time-lapse imaging to document cell-scale dynamics during progression of GA.Clinical Trial Registrationclinicaltrials.gov, identifier: NCT04128150 and NCT04129021.https://www.frontiersin.org/articles/10.3389/fmed.2022.868163/fullage-related macular degenerationgeographic atrophyscanning laser ophthalmoscopyoptical coherence tomographytime-lapse imaging |
| spellingShingle | Michel Paques Michel Paques Nathaniel Norberg Céline Chaumette Florian Sennlaub Ethan Rossi Ysé Borella Ysé Borella Kate Grieve Kate Grieve Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study Frontiers in Medicine age-related macular degeneration geographic atrophy scanning laser ophthalmoscopy optical coherence tomography time-lapse imaging |
| title | Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study |
| title_full | Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study |
| title_fullStr | Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study |
| title_full_unstemmed | Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study |
| title_short | Long Term Time-Lapse Imaging of Geographic Atrophy: A Pilot Study |
| title_sort | long term time lapse imaging of geographic atrophy a pilot study |
| topic | age-related macular degeneration geographic atrophy scanning laser ophthalmoscopy optical coherence tomography time-lapse imaging |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.868163/full |
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