Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs

The market for illicit drugs and new psychoactive substances (NPS) has grown significantly and people attending festivals have been identified as being at high risk (high extent and frequency of substance use). Traditional public health surveillance data sources have limitations (high costs, long im...

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Main Authors: Nikolaos Rousis, Richard Bade, Iván Romero-Sánchez, Jochen F. Mueller, Nikolaos S. Thomaidis, Kevin V. Thomas, Emma Gracia-Lor
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Environment International
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412023003483
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author Nikolaos Rousis
Richard Bade
Iván Romero-Sánchez
Jochen F. Mueller
Nikolaos S. Thomaidis
Kevin V. Thomas
Emma Gracia-Lor
author_facet Nikolaos Rousis
Richard Bade
Iván Romero-Sánchez
Jochen F. Mueller
Nikolaos S. Thomaidis
Kevin V. Thomas
Emma Gracia-Lor
author_sort Nikolaos Rousis
collection DOAJ
description The market for illicit drugs and new psychoactive substances (NPS) has grown significantly and people attending festivals have been identified as being at high risk (high extent and frequency of substance use). Traditional public health surveillance data sources have limitations (high costs, long implementation times, and ethical issues) and wastewater-based epidemiology (WBE) can cost-effectively support surveillance efforts. Influent wastewater samples were analyzed for NPS and illicit drug consumption collected during New Year period (from 29-Dec-2021 to 4-Jan-2022) and a summer Festival (from 29-June-2022 to 12-July-2022) in a large city in Spain. Samples were analyzed for phenethylamines, cathinones, opioids, benzodiazepines, plant-based NPS, dissociatives, and the illicit drugs methamphetamine, MDA, MDMA, ketamine, heroin, cocaine, and pseudoephedrine by liquid chromatography mass spectrometry. High consumption rates of specific NPS and established illicit drugs were identified at the peak of each event. Furthermore, a dynamic change in NPS use (presence and absence of substances) was detected over a period of six months. Eleven NPS, including synthetic cathinones, benzodiazepines, plant-based NPS and dissociatives, and seven illicit drugs were found across both the New Year and summer Festival. Statistically significant differences (p < 0.05) were seen for 3-MMC (New Year vs summer Festival), eutylone (New Year vs summer Festival), cocaine (summer Festival vs normal week and summer Festival vs New Year), MDMA (New Year vs normal week and summer Festival vs normal week), heroin (summer Festival vs New Year) and pseudoephedrine (summer Festival vs New Year). This WBE study assessed the prevalence of NPS and illicit drugs at festivals following the reduction of the COVID-19 pandemic restrictions highlighting the high use of specific substances at the peak of each event. This approach identified in a cost-effective and timely manner without any ethical issues the most used drugs and changes in use patterns and, thus, can complement public health information.
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spelling doaj.art-c2140e51a89e4a13977c449538b024472023-08-16T04:26:20ZengElsevierEnvironment International0160-41202023-08-01178108075Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugsNikolaos Rousis0Richard Bade1Iván Romero-Sánchez2Jochen F. Mueller3Nikolaos S. Thomaidis4Kevin V. Thomas5Emma Gracia-Lor6Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece; Corresponding authors at: Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia (N.R.).Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia; Corresponding authors at: Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia (N.R.).Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Avenida Complutense s/n, 28040 Madrid, SpainQueensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, AustraliaLaboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceQueensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, AustraliaDepartment of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Avenida Complutense s/n, 28040 Madrid, Spain; Corresponding authors at: Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia (N.R.).The market for illicit drugs and new psychoactive substances (NPS) has grown significantly and people attending festivals have been identified as being at high risk (high extent and frequency of substance use). Traditional public health surveillance data sources have limitations (high costs, long implementation times, and ethical issues) and wastewater-based epidemiology (WBE) can cost-effectively support surveillance efforts. Influent wastewater samples were analyzed for NPS and illicit drug consumption collected during New Year period (from 29-Dec-2021 to 4-Jan-2022) and a summer Festival (from 29-June-2022 to 12-July-2022) in a large city in Spain. Samples were analyzed for phenethylamines, cathinones, opioids, benzodiazepines, plant-based NPS, dissociatives, and the illicit drugs methamphetamine, MDA, MDMA, ketamine, heroin, cocaine, and pseudoephedrine by liquid chromatography mass spectrometry. High consumption rates of specific NPS and established illicit drugs were identified at the peak of each event. Furthermore, a dynamic change in NPS use (presence and absence of substances) was detected over a period of six months. Eleven NPS, including synthetic cathinones, benzodiazepines, plant-based NPS and dissociatives, and seven illicit drugs were found across both the New Year and summer Festival. Statistically significant differences (p < 0.05) were seen for 3-MMC (New Year vs summer Festival), eutylone (New Year vs summer Festival), cocaine (summer Festival vs normal week and summer Festival vs New Year), MDMA (New Year vs normal week and summer Festival vs normal week), heroin (summer Festival vs New Year) and pseudoephedrine (summer Festival vs New Year). This WBE study assessed the prevalence of NPS and illicit drugs at festivals following the reduction of the COVID-19 pandemic restrictions highlighting the high use of specific substances at the peak of each event. This approach identified in a cost-effective and timely manner without any ethical issues the most used drugs and changes in use patterns and, thus, can complement public health information.http://www.sciencedirect.com/science/article/pii/S0160412023003483Wastewater-based epidemiologySynthetic cathinones3-chloromethcathinone (3-CMC)N,N-dimethylpentylone2F-deschloroketamine (2F-DCK)Substance abuse
spellingShingle Nikolaos Rousis
Richard Bade
Iván Romero-Sánchez
Jochen F. Mueller
Nikolaos S. Thomaidis
Kevin V. Thomas
Emma Gracia-Lor
Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs
Environment International
Wastewater-based epidemiology
Synthetic cathinones
3-chloromethcathinone (3-CMC)
N,N-dimethylpentylone
2F-deschloroketamine (2F-DCK)
Substance abuse
title Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs
title_full Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs
title_fullStr Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs
title_full_unstemmed Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs
title_short Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs
title_sort festivals following the easing of covid 19 restrictions prevalence of new psychoactive substances and illicit drugs
topic Wastewater-based epidemiology
Synthetic cathinones
3-chloromethcathinone (3-CMC)
N,N-dimethylpentylone
2F-deschloroketamine (2F-DCK)
Substance abuse
url http://www.sciencedirect.com/science/article/pii/S0160412023003483
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