Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical Trials
The purpose of this study was to evaluate the efficacy and safety of photobiomodulation as an adjuvant treatment for primary headache. A systematic review of randomized clinical trials was performed. For such, electronic searches were performed in the MEDLINE, Embase, Cochrane Library, LILACS, PEDro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/1/98 |
| _version_ | 1797492719403139072 |
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| author | Andréa Oliver Gomes Ana Luiza Cabrera Martimbianco Aldo Brugnera Junior Anna Carolina Ratto Tempestini Horliana Tamiris da Silva Elaine Marcílio Santos Yara Dadalti Fragoso Kristianne Porta Santos Fernandes Samir Nammour Sandra Kalil Bussadori |
| author_facet | Andréa Oliver Gomes Ana Luiza Cabrera Martimbianco Aldo Brugnera Junior Anna Carolina Ratto Tempestini Horliana Tamiris da Silva Elaine Marcílio Santos Yara Dadalti Fragoso Kristianne Porta Santos Fernandes Samir Nammour Sandra Kalil Bussadori |
| author_sort | Andréa Oliver Gomes |
| collection | DOAJ |
| description | The purpose of this study was to evaluate the efficacy and safety of photobiomodulation as an adjuvant treatment for primary headache. A systematic review of randomized clinical trials was performed. For such, electronic searches were performed in the MEDLINE, Embase, Cochrane Library, LILACS, PEDro, PsycInfo, Clinicaltrials.gov., and WHO/ICTRP databases, with no restrictions imposed regarding language or year of publication. We included studies that assessed any photobiomodulation therapy as an adjuvant treatment for primary headache compared to sham treatment, no treatment, or another intervention. The methodological assessment was conducted using the Cochrane Risk of Bias tool. The certainty of the evidence was classified using the GRADE approach. Four randomized clinical trials were included. Most of the included studies had an overall high risk of bias. Compared to sham treatment, photobiomodulation had a clinically important effect on pain in individuals with primary headache. Despite the benefits reported for other outcomes, the estimates were imprecise, and the certainty of the evidence was graded as low. These findings are considered insufficient to support the use of photobiomodulation in the treatment of primary headache. Randomized clinical trials, with higher methodological quality, are needed to enhance the reliability of the estimated effects. |
| first_indexed | 2024-03-10T01:06:47Z |
| format | Article |
| id | doaj.art-c21421b4e68348cfaebc6bb29f6908d1 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T01:06:47Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-c21421b4e68348cfaebc6bb29f6908d12023-11-23T14:24:59ZengMDPI AGLife2075-17292022-01-011219810.3390/life12010098Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical TrialsAndréa Oliver Gomes0Ana Luiza Cabrera Martimbianco1Aldo Brugnera Junior2Anna Carolina Ratto Tempestini Horliana3Tamiris da Silva4Elaine Marcílio Santos5Yara Dadalti Fragoso6Kristianne Porta Santos Fernandes7Samir Nammour8Sandra Kalil Bussadori9Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), Street Vergueiro, 235/249-Liberdade, São Paulo 05503-900, BrazilPostgraduate Program in Health and Environment, Universidade Metropolitana de Santos (UNIMES), São Paulo 05503-900, BrazilPhysics Institute of São Carlos (IFSC/USP), Universidade de São Paulo, São Paulo 05503-900, BrazilPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), São Paulo 05503-900, BrazilPostgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), Street Vergueiro, 235/249-Liberdade, São Paulo 05503-900, BrazilPostgraduate Program in Health and Environment, Universidade Metropolitana de Santos (UNIMES), São Paulo 05503-900, BrazilPostgraduate Program in Health and Environment, Universidade Metropolitana de Santos (UNIMES), São Paulo 05503-900, BrazilPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), São Paulo 05503-900, BrazilDepartment of Dental Science, Faculty of Medicine, University of Liege, 4000 Liege, BelgiumPostgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), Street Vergueiro, 235/249-Liberdade, São Paulo 05503-900, BrazilThe purpose of this study was to evaluate the efficacy and safety of photobiomodulation as an adjuvant treatment for primary headache. A systematic review of randomized clinical trials was performed. For such, electronic searches were performed in the MEDLINE, Embase, Cochrane Library, LILACS, PEDro, PsycInfo, Clinicaltrials.gov., and WHO/ICTRP databases, with no restrictions imposed regarding language or year of publication. We included studies that assessed any photobiomodulation therapy as an adjuvant treatment for primary headache compared to sham treatment, no treatment, or another intervention. The methodological assessment was conducted using the Cochrane Risk of Bias tool. The certainty of the evidence was classified using the GRADE approach. Four randomized clinical trials were included. Most of the included studies had an overall high risk of bias. Compared to sham treatment, photobiomodulation had a clinically important effect on pain in individuals with primary headache. Despite the benefits reported for other outcomes, the estimates were imprecise, and the certainty of the evidence was graded as low. These findings are considered insufficient to support the use of photobiomodulation in the treatment of primary headache. Randomized clinical trials, with higher methodological quality, are needed to enhance the reliability of the estimated effects.https://www.mdpi.com/2075-1729/12/1/98painprimary headachephotobiomodulationlow-level laser |
| spellingShingle | Andréa Oliver Gomes Ana Luiza Cabrera Martimbianco Aldo Brugnera Junior Anna Carolina Ratto Tempestini Horliana Tamiris da Silva Elaine Marcílio Santos Yara Dadalti Fragoso Kristianne Porta Santos Fernandes Samir Nammour Sandra Kalil Bussadori Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical Trials Life pain primary headache photobiomodulation low-level laser |
| title | Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical Trials |
| title_full | Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical Trials |
| title_fullStr | Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical Trials |
| title_full_unstemmed | Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical Trials |
| title_short | Photobiomodulation for the Treatment of Primary Headache: Systematic Review of Randomized Clinical Trials |
| title_sort | photobiomodulation for the treatment of primary headache systematic review of randomized clinical trials |
| topic | pain primary headache photobiomodulation low-level laser |
| url | https://www.mdpi.com/2075-1729/12/1/98 |
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