Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium
Summary: Experience-dependent brain circuit plasticity underlies various sensorimotor learning and memory processes. Recently, a novel set-point adaptation mechanism was identified that accounts for the pronounced negative optokinetic afternystagmus (OKAN) following a sustained period of unidirectio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222016078 |
| _version_ | 1811326282770677760 |
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| author | Ting-Feng Lin Mohammad Mohammadi Kathleen E. Cullen Maurice J. Chacron Melody Ying-Yu Huang |
| author_facet | Ting-Feng Lin Mohammad Mohammadi Kathleen E. Cullen Maurice J. Chacron Melody Ying-Yu Huang |
| author_sort | Ting-Feng Lin |
| collection | DOAJ |
| description | Summary: Experience-dependent brain circuit plasticity underlies various sensorimotor learning and memory processes. Recently, a novel set-point adaptation mechanism was identified that accounts for the pronounced negative optokinetic afternystagmus (OKAN) following a sustained period of unidirectional optokinetic nystagmus (OKN) in larval zebrafish. To investigate the physiological significance of optokinetic set-point adaptation, animals in the current study were exposed to a direction-alternating optokinetic stimulation paradigm that better resembles their visual experience in nature. Our results reveal that not only was asymmetric alternating stimulation sufficient to induce the set-point adaptation and the resulting negative OKAN, but most strikingly, under symmetric alternating stimulation some animals displayed an inherent bias of the OKN gain in one direction, and that was compensated by the similar set-point adaptation. This finding, supported by mathematical modeling, suggests that set-point adaptation allows animals to cope with asymmetric optokinetic behaviors evoked by either external stimuli or innate oculomotor biases. |
| first_indexed | 2024-04-13T14:47:16Z |
| format | Article |
| id | doaj.art-c21508523bb3427d9eb27444acbef109 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-13T14:47:16Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-c21508523bb3427d9eb27444acbef1092022-12-22T02:42:42ZengElsevieriScience2589-00422022-11-012511105335Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibriumTing-Feng Lin0Mohammad Mohammadi1Kathleen E. Cullen2Maurice J. Chacron3Melody Ying-Yu Huang4Department of Neurology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland; Corresponding authorDepartment of Biomedical Engineering, McGill University, Montreal, QC, CanadaDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Kavli Neuroscience Discovery Institute, The Johns Hopkins University, Baltimore, MD, USADepartment of Physiology, McGill University, Montreal, QC, CanadaDepartment of Neurology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland; Corresponding authorSummary: Experience-dependent brain circuit plasticity underlies various sensorimotor learning and memory processes. Recently, a novel set-point adaptation mechanism was identified that accounts for the pronounced negative optokinetic afternystagmus (OKAN) following a sustained period of unidirectional optokinetic nystagmus (OKN) in larval zebrafish. To investigate the physiological significance of optokinetic set-point adaptation, animals in the current study were exposed to a direction-alternating optokinetic stimulation paradigm that better resembles their visual experience in nature. Our results reveal that not only was asymmetric alternating stimulation sufficient to induce the set-point adaptation and the resulting negative OKAN, but most strikingly, under symmetric alternating stimulation some animals displayed an inherent bias of the OKN gain in one direction, and that was compensated by the similar set-point adaptation. This finding, supported by mathematical modeling, suggests that set-point adaptation allows animals to cope with asymmetric optokinetic behaviors evoked by either external stimuli or innate oculomotor biases.http://www.sciencedirect.com/science/article/pii/S2589004222016078Biological sciencesneurosciencesensory neuroscience |
| spellingShingle | Ting-Feng Lin Mohammad Mohammadi Kathleen E. Cullen Maurice J. Chacron Melody Ying-Yu Huang Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium iScience Biological sciences neuroscience sensory neuroscience |
| title | Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium |
| title_full | Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium |
| title_fullStr | Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium |
| title_full_unstemmed | Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium |
| title_short | Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium |
| title_sort | optokinetic set point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium |
| topic | Biological sciences neuroscience sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222016078 |
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