Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials
Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. In this study, we compare the toxicological effects of pristine TiO<sub>2</sub...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/9/7/968 |
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| author | Monika Remzova Radek Zouzelka Tana Brzicova Kristyna Vrbova Dominik Pinkas Pavel Rőssner Jan Topinka Jiri Rathousky |
| author_facet | Monika Remzova Radek Zouzelka Tana Brzicova Kristyna Vrbova Dominik Pinkas Pavel Rőssner Jan Topinka Jiri Rathousky |
| author_sort | Monika Remzova |
| collection | DOAJ |
| description | Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. In this study, we compare the toxicological effects of pristine TiO<sub>2</sub>, ZnO, SiO<sub>2</sub>, and coated SiO<sub>2</sub> nanoparticles, and evaluate their suitability as additives to consolidants of weathered construction materials. First, water soluble tetrazolium 1 (WST-1) and lactate dehydrogenase (LDH) assays were used to determine the viability of human alveolar A549 cells at various nanoparticle concentrations (0−250 μg mL<sup>−1</sup>). While the pristine TiO<sub>2</sub> and coated SiO<sub>2</sub> nanoparticles did not exhibit any cytotoxic effects up to the highest tested concentration, the pristine SiO<sub>2</sub> and ZnO nanoparticles significantly reduced cell viability. Second, as all developed nanoparticle-modified consolidants increased the mechanical strength of weathered sandstone, the decisive criterion for the selection of the most suitable nanoparticle additive was as low toxicity as possible. We believe that this approach would be of high importance in the industry, to identify materials representing top functional properties and low toxicity, at an early stage of the product development. |
| first_indexed | 2024-12-21T15:27:37Z |
| format | Article |
| id | doaj.art-c21538931fac41fb8966826d797f206f |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-21T15:27:37Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-c21538931fac41fb8966826d797f206f2022-12-21T18:58:52ZengMDPI AGNanomaterials2079-49912019-07-019796810.3390/nano9070968nano9070968Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction MaterialsMonika Remzova0Radek Zouzelka1Tana Brzicova2Kristyna Vrbova3Dominik Pinkas4Pavel Rőssner5Jan Topinka6Jiri Rathousky7J. Heyrovsky Institute of Physical Chemistry of the CAS, Dolejskova 3, 18223 Prague, Czech RepublicJ. Heyrovsky Institute of Physical Chemistry of the CAS, Dolejskova 3, 18223 Prague, Czech RepublicInstitute of Experimental Medicine of the CAS, Videnska 1083, 14220 Prague, Czech RepublicInstitute of Experimental Medicine of the CAS, Videnska 1083, 14220 Prague, Czech RepublicInstitute of Molecular Genetics of the CAS, Microscopy Center, Electron Microscopy Core Facility, 14220 Prague, Czech RepublicInstitute of Experimental Medicine of the CAS, Videnska 1083, 14220 Prague, Czech RepublicInstitute of Experimental Medicine of the CAS, Videnska 1083, 14220 Prague, Czech RepublicJ. Heyrovsky Institute of Physical Chemistry of the CAS, Dolejskova 3, 18223 Prague, Czech RepublicRapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. In this study, we compare the toxicological effects of pristine TiO<sub>2</sub>, ZnO, SiO<sub>2</sub>, and coated SiO<sub>2</sub> nanoparticles, and evaluate their suitability as additives to consolidants of weathered construction materials. First, water soluble tetrazolium 1 (WST-1) and lactate dehydrogenase (LDH) assays were used to determine the viability of human alveolar A549 cells at various nanoparticle concentrations (0−250 μg mL<sup>−1</sup>). While the pristine TiO<sub>2</sub> and coated SiO<sub>2</sub> nanoparticles did not exhibit any cytotoxic effects up to the highest tested concentration, the pristine SiO<sub>2</sub> and ZnO nanoparticles significantly reduced cell viability. Second, as all developed nanoparticle-modified consolidants increased the mechanical strength of weathered sandstone, the decisive criterion for the selection of the most suitable nanoparticle additive was as low toxicity as possible. We believe that this approach would be of high importance in the industry, to identify materials representing top functional properties and low toxicity, at an early stage of the product development.https://www.mdpi.com/2079-4991/9/7/968SiO<sub>2</sub> nanoparticlesZnO nanoparticlesTiO<sub>2</sub> nanoparticlestoxicityethyl silicate consolidants |
| spellingShingle | Monika Remzova Radek Zouzelka Tana Brzicova Kristyna Vrbova Dominik Pinkas Pavel Rőssner Jan Topinka Jiri Rathousky Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials Nanomaterials SiO<sub>2</sub> nanoparticles ZnO nanoparticles TiO<sub>2</sub> nanoparticles toxicity ethyl silicate consolidants |
| title | Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials |
| title_full | Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials |
| title_fullStr | Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials |
| title_full_unstemmed | Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials |
| title_short | Toxicity of TiO<sub>2</sub>, ZnO, and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials |
| title_sort | toxicity of tio sub 2 sub zno and sio sub 2 sub nanoparticles in human lung cells safe by design development of construction materials |
| topic | SiO<sub>2</sub> nanoparticles ZnO nanoparticles TiO<sub>2</sub> nanoparticles toxicity ethyl silicate consolidants |
| url | https://www.mdpi.com/2079-4991/9/7/968 |
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