A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) have exhibited several beneficial effects on LPS-stimulated macrophages and murine experimental systemic lupus erythematosus (SLE). This study was designed to evaluate dietary Per-OL in comparison with OL supplementat...

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Bibliographic Details
Main Authors: María Luisa Castejón, Catalina Alarcón-de-la-Lastra, María Ángeles Rosillo, Tatiana Montoya, Jose G. Fernández-Bolaños, Alejandro González-Benjumea, Marina Sánchez-Hidalgo
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Nutrients
Subjects:
arthritis
CIA
inflammation
MAPK
NF-κB
Nrf2/HO1
Online Access:https://www.mdpi.com/2072-6643/13/2/311

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