Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study

A new series of 4,6-disubstituted 2-(4-(dimethylamino)styryl)quinoline 4a,b–9a,b was synthesized by the reaction of 2-(4-(dimethylamino)styryl)-6-substituted quinoline-4-carboxylic acids 3a,b with thiosemicarbazide, p-hydroxybenzaldehyde, ethylcyanoacetate, and 2,4-pentandione. In addition, the anti...

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Bibliographic Details
Main Authors: Magda A.-A. El-Sayed, Walaa M. El-Husseiny, Naglaa I. Abdel-Aziz, Adel S. El-Azab, Hatem A. Abuelizz, Alaa A.-M. Abdel-Aziz
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Styrylquinoline
thiadiazole
synthesis
antitumour
EGFR kinase inhibitors
molecular docking
Online Access:http://dx.doi.org/10.1080/14756366.2017.1407926

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