Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort
Background: Epidemiologic studies suggest an increased risk of leukemia among individuals occupationally exposed to some organochlorine (OC) compounds. Associations between serum OC pesticide and polychlorinated biphenyl (PCB) levels and risk of acute myeloid leukemia (AML), the most common subtype...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-04-01
|
| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018317562 |
| _version_ | 1818948972361809920 |
|---|---|
| author | Bryan A. Bassig Lawrence S. Engel Hilde Langseth Tom K. Grimsrud Kenneth P. Cantor Roel Vermeulen Mark P. Purdue Dana Boyd Barr Jason Y.Y. Wong Aaron Blair Nathaniel Rothman Qing Lan |
| author_facet | Bryan A. Bassig Lawrence S. Engel Hilde Langseth Tom K. Grimsrud Kenneth P. Cantor Roel Vermeulen Mark P. Purdue Dana Boyd Barr Jason Y.Y. Wong Aaron Blair Nathaniel Rothman Qing Lan |
| author_sort | Bryan A. Bassig |
| collection | DOAJ |
| description | Background: Epidemiologic studies suggest an increased risk of leukemia among individuals occupationally exposed to some organochlorine (OC) compounds. Associations between serum OC pesticide and polychlorinated biphenyl (PCB) levels and risk of acute myeloid leukemia (AML), the most common subtype of acute leukemia in adult populations, have not been evaluated prospectively in the general population. Objective: We evaluated the risk of AML in relation to pre-diagnostic serum levels of OC pesticides and PCBs in a case-control study nested within the Janus Serum Bank Cohort. Methods: Janus is a large population-based cohort containing biologic samples collected beginning in the early 1970s from ~318,000 individuals in Norway. Serum levels of 11 OC pesticides or their metabolites and 34 PCB congeners were measured in 56 AML cases and 288 controls. Conditional logistic regression was conducted to evaluate associations between lipid-adjusted serum OC levels and risk of AML. Results: Higher serum levels of total chlordane/heptachlor metabolites were associated with AML risk (3rd vs. 1st tertile odds ratio (OR) = 2.26, 95% confidence interval (CI) = 0.91–5.63; ptrend = 0.11). Significant exposure-response associations were observed for levels of heptachlor epoxide (3rd vs. 1st tertile OR = 2.85, 95% CI = 1.05–7.73; ptrend = 0.02) and dieldrin (3rd vs. 1st tertile OR = 2.71, 95% CI = 1.07–6.83; ptrend = 0.03). No significant exposure-response associations with AML risk were observed for total DDT or individual isomers and derivatives. Higher serum levels of p,p′-DDT showed a non-significant increase in risk, but the exposure-response became attenuated when co-adjusting for heptachlor epoxide or dieldrin levels. Serum PCB levels were not significantly associated with AML risk. Conclusions: Our data suggest that higher serum levels of dieldrin and metabolites derived from chlordane/heptachlor are associated with risk of AML in the general Norwegian population, based on samples collected on average ~17 years before diagnosis. Further research in populations with historically high or recent exposure to DDT is warranted to assess the association with AML risk with body burden of specific DDT isomers and derivatives. Keywords: Acute myeloid leukemia, Organochlorines, Pesticides, Polychlorinated biphenyls |
| first_indexed | 2024-12-20T08:55:17Z |
| format | Article |
| id | doaj.art-c2178da027e24bbb80237d4b9eb74946 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-20T08:55:17Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-c2178da027e24bbb80237d4b9eb749462022-12-21T19:46:02ZengElsevierEnvironment International0160-41202019-04-01125229235Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank CohortBryan A. Bassig0Lawrence S. Engel1Hilde Langseth2Tom K. Grimsrud3Kenneth P. Cantor4Roel Vermeulen5Mark P. Purdue6Dana Boyd Barr7Jason Y.Y. Wong8Aaron Blair9Nathaniel Rothman10Qing Lan11Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA; Corresponding author at: Occupational & Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Rm. 6E132, Rockville, MD 20850, USA.Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USADepartment of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, NorwayDepartment of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, NorwayOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USAInstitute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, the NetherlandsOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USADepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USAOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USAOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USAOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USAOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USABackground: Epidemiologic studies suggest an increased risk of leukemia among individuals occupationally exposed to some organochlorine (OC) compounds. Associations between serum OC pesticide and polychlorinated biphenyl (PCB) levels and risk of acute myeloid leukemia (AML), the most common subtype of acute leukemia in adult populations, have not been evaluated prospectively in the general population. Objective: We evaluated the risk of AML in relation to pre-diagnostic serum levels of OC pesticides and PCBs in a case-control study nested within the Janus Serum Bank Cohort. Methods: Janus is a large population-based cohort containing biologic samples collected beginning in the early 1970s from ~318,000 individuals in Norway. Serum levels of 11 OC pesticides or their metabolites and 34 PCB congeners were measured in 56 AML cases and 288 controls. Conditional logistic regression was conducted to evaluate associations between lipid-adjusted serum OC levels and risk of AML. Results: Higher serum levels of total chlordane/heptachlor metabolites were associated with AML risk (3rd vs. 1st tertile odds ratio (OR) = 2.26, 95% confidence interval (CI) = 0.91–5.63; ptrend = 0.11). Significant exposure-response associations were observed for levels of heptachlor epoxide (3rd vs. 1st tertile OR = 2.85, 95% CI = 1.05–7.73; ptrend = 0.02) and dieldrin (3rd vs. 1st tertile OR = 2.71, 95% CI = 1.07–6.83; ptrend = 0.03). No significant exposure-response associations with AML risk were observed for total DDT or individual isomers and derivatives. Higher serum levels of p,p′-DDT showed a non-significant increase in risk, but the exposure-response became attenuated when co-adjusting for heptachlor epoxide or dieldrin levels. Serum PCB levels were not significantly associated with AML risk. Conclusions: Our data suggest that higher serum levels of dieldrin and metabolites derived from chlordane/heptachlor are associated with risk of AML in the general Norwegian population, based on samples collected on average ~17 years before diagnosis. Further research in populations with historically high or recent exposure to DDT is warranted to assess the association with AML risk with body burden of specific DDT isomers and derivatives. Keywords: Acute myeloid leukemia, Organochlorines, Pesticides, Polychlorinated biphenylshttp://www.sciencedirect.com/science/article/pii/S0160412018317562 |
| spellingShingle | Bryan A. Bassig Lawrence S. Engel Hilde Langseth Tom K. Grimsrud Kenneth P. Cantor Roel Vermeulen Mark P. Purdue Dana Boyd Barr Jason Y.Y. Wong Aaron Blair Nathaniel Rothman Qing Lan Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort Environment International |
| title | Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort |
| title_full | Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort |
| title_fullStr | Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort |
| title_full_unstemmed | Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort |
| title_short | Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort |
| title_sort | pre diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia a nested case control study in the norwegian janus serum bank cohort |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018317562 |
| work_keys_str_mv | AT bryanabassig prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT lawrencesengel prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT hildelangseth prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT tomkgrimsrud prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT kennethpcantor prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT roelvermeulen prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT markppurdue prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT danaboydbarr prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT jasonyywong prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT aaronblair prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT nathanielrothman prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort AT qinglan prediagnosticserumconcentrationsoforganochlorinesandriskofacutemyeloidleukemiaanestedcasecontrolstudyinthenorwegianjanusserumbankcohort |