Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method
From unstable crystals to relatively stable monohydrate crystals, many researchers have been working on S-nitrosocaptopril for more than two decades. S-nitrosocaptopril monohydrate (Cap-NO·H<sub>2</sub>O) is a novel crystal form of S-nitrosocaptopril (Cap-NO), and is not only a nitric ox...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/24/7533 |
| _version_ | 1797502205041836032 |
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| author | Lingyi Huang Yu Zhou Yizhi Wang Min Lin |
| author_facet | Lingyi Huang Yu Zhou Yizhi Wang Min Lin |
| author_sort | Lingyi Huang |
| collection | DOAJ |
| description | From unstable crystals to relatively stable monohydrate crystals, many researchers have been working on S-nitrosocaptopril for more than two decades. S-nitrosocaptopril monohydrate (Cap-NO·H<sub>2</sub>O) is a novel crystal form of S-nitrosocaptopril (Cap-NO), and is not only a nitric oxide (NO) donor, but also an angiotensin-converting enzyme inhibitor (ACEI). Yet, a method for long-term storage has never been reported. In order to determine the optimal storage conditions, Plackett–Burman (PB) design was performed to confirm the critical factors. Response surface methodology (RSM) was employed to determine the optimal Cap-NO·H<sub>2</sub>O storage condition, based on the rough interval determined by the path of steepest ascent experiment. The optimized storage condition was denoted as nitrogen purity of 97%, temperature of −10 °C and 1.20 g deoxidizer. In this case, a final preservation rate of 97.91 ± 0.59% could be obtained. In specific storage conditions, Cap-NO·H<sub>2</sub>O was found to be stable for at least 6 months in individual PE package, procreating a potentially applicable avenue. |
| first_indexed | 2024-03-10T03:29:37Z |
| format | Article |
| id | doaj.art-c2184d5c0b174ee09f58a6729280db14 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:29:37Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-c2184d5c0b174ee09f58a6729280db142023-11-23T09:45:31ZengMDPI AGMolecules1420-30492021-12-012624753310.3390/molecules26247533Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface MethodLingyi Huang0Yu Zhou1Yizhi Wang2Min Lin3School of Pharmacy, Fujian Medical University, Fuzhou 350122, ChinaKey Laboratory for Chemical Biology of Fujian Province, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaSchool of Intelligent Science and Control Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaNanjing Leechdom Biopharm Technology Co., Ltd., Nanjing 211500, ChinaFrom unstable crystals to relatively stable monohydrate crystals, many researchers have been working on S-nitrosocaptopril for more than two decades. S-nitrosocaptopril monohydrate (Cap-NO·H<sub>2</sub>O) is a novel crystal form of S-nitrosocaptopril (Cap-NO), and is not only a nitric oxide (NO) donor, but also an angiotensin-converting enzyme inhibitor (ACEI). Yet, a method for long-term storage has never been reported. In order to determine the optimal storage conditions, Plackett–Burman (PB) design was performed to confirm the critical factors. Response surface methodology (RSM) was employed to determine the optimal Cap-NO·H<sub>2</sub>O storage condition, based on the rough interval determined by the path of steepest ascent experiment. The optimized storage condition was denoted as nitrogen purity of 97%, temperature of −10 °C and 1.20 g deoxidizer. In this case, a final preservation rate of 97.91 ± 0.59% could be obtained. In specific storage conditions, Cap-NO·H<sub>2</sub>O was found to be stable for at least 6 months in individual PE package, procreating a potentially applicable avenue.https://www.mdpi.com/1420-3049/26/24/7533S-nitrosocaptopril monohydratetemperaturenitrogen puritydeoxidizer |
| spellingShingle | Lingyi Huang Yu Zhou Yizhi Wang Min Lin Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method Molecules S-nitrosocaptopril monohydrate temperature nitrogen purity deoxidizer |
| title | Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method |
| title_full | Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method |
| title_fullStr | Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method |
| title_full_unstemmed | Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method |
| title_short | Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method |
| title_sort | optimization of s nitrosocaptopril monohydrate storage conditions based on response surface method |
| topic | S-nitrosocaptopril monohydrate temperature nitrogen purity deoxidizer |
| url | https://www.mdpi.com/1420-3049/26/24/7533 |
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